Melatonin Ameliorates Neuropharmacological and Neurobiochemical Alterations Induced by Subchronic Exposure to Arsenic in Wistar Rats

Durappanavar, Prasada Ningappa; Nadoor, Prakash; Waghe, Prashantkumar; Pavithra, B. H.; Jayaramu, G. M.

doi:10.1007/s12011-018-1537-1

Cited by 16 publications

(4 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present work, the reduction in GSH level observed in As2O3 alone treated groups was more pronounced with higher dosages of As2O3 (4 & 8 mg/kg). These findings are in concordance with the earlier reports [75,77,81,82]. Depletion of GSH may be due to its utilization either by the toxic radicals or by the intermediates formed during methylation of arsenic in presence of SAM (S-adenosylmethionine) [82].…”

Section: Discussionsupporting

confidence: 93%

“…These findings are in concordance with the earlier reports [75,77,81,82]. Depletion of GSH may be due to its utilization either by the toxic radicals or by the intermediates formed during methylation of arsenic in presence of SAM (S-adenosylmethionine) [82]. Another reason for low levels of GSH may be the direct binding of arsenic with thiol groups present in GSH to form As(GS)3 [83][84][85].…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Curcumin alleviates Arsenic trioxide-induced behavioural impairment, oxidative damage & morphological alterations in striatal region of mice brain

Pandey,

Mehta,

Kaur

et al. 2023

Preprint

View full text Add to dashboard Cite

Arsenic-induced neurotoxicity is well-documented in literature and reported to have dose-dependent damaging effects in the mice brain. Curcumin, a cost-effective plant polyphenol, safely demonstrates protective effects against arsenic-induced neurotoxicity by modifying oxidative stress, apoptosis, and neurochemistry in rodents’ brain.The present study determined the neuroprotective potential of curcumin (CUR) on adverse effects induced by arsenic trioxide (As2O3) in mice striatal region. Healthy adult male mice were chronically administered with varying concentrations of As2O3(2, 4 & 8 mg/kg bw) alone and along with CUR (100 mg/kg bw) via oral route for 45 days. Towards the end of experimental period, the animals were subjected to behavioural paradigm including open field task, novel object recognition, rota-rod and morris water maze. Fresh striatal tissues were collected from the animals on day 46 for biochemical analysis such as MDA, GPx and GSH. While perfusion fixed brains were processed for morphological observations.Behavioural study showed an apparent decrease in certain cognitive functions (learning and memory) and locomotor activity in mice exposed to As2O3compared to controls. Simultaneous treatment of As2O3(2, 4 & 8 mg/kg bw) and curcumin (100 mg/kg bw) alleviated theAs-induced locomotor and cognitive deficits. As2O3alone exposure also exhibited a significant increase in oxidative stress marker (MDA) and decrease in antioxidant enzyme levels (GPx, GSH). Morphological alterations were noted in mice subjected to elevated doses of As2O3(4 & 8 mg/kg bw). However, these changes were reversed in mice who received As2O3+ CUR co-treatment. Together, our findings provide preliminary evidence that curcumin protects mice striatal region from As2O3-induced behavioral, biochemical and morphological alterations.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Curcumin alleviates Arsenic trioxide-induced behavioural impairment, oxidative damage & morphological alterations in striatal region of mice brain

Pandey,

Mehta,

Kaur

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Pal et al also found similar effects in Wistar rats, added that melatonin supplementation was also able to inhibit lipid peroxidation in the liver tissue (Pal & Chatterjee, 2006). Durappanvar et al (2019) studied the neurologic effects of subchronic arsenic exposure in male Wistar rats and found that this exposure leads to reduced voluntary locomotor and forced motor activities, increase in anxiety levels, a marginal reduction in pain latency, and increase in the levels of MDA and 3‐nitrotyrosine in the brain tissue. Melatonin supplementation was able to reverse all of the aforementioned changes, and was also able to reduce the levels of PGE2 and proinflammatory cytokines in the brain (Durappanavar et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Molecular mechanisms underlying ameliorative impact of melatonin against age‐dependent chronic arsenic toxicity in rats' brains

2022

View full text Add to dashboard Cite

Accumulation of random molecular damage such as oxidative DNA damage and inflammation is extremely found to be involved in the aging process. Due to extreme energy requirements and high lipid levels, the brain is more susceptible to oxidative damage during aging especially under exposure to toxic elements such as arsenic. Therefore, this study was aimed to evaluate the ameliorative effects of melatonin, as a neurohormone, on the arsenic‐induced behavioral abnormalities, and the underlying mechanisms. Forty‐eight rats, as young and old aged groups were exposed to 5.55 g/kg body weight arsenic for 4 weeks and then 10 mg/kg melatonin for 2 weeks. Our results showed that arsenic led to anxiety‐like behavioral abnormalities in rats. Increased oxidative stress‐induced damage to DNA, lipids and proteins, decreased potential of antioxidant defense system, induced apoptosis, elevated inflammation, and alteration in the histology of cortical region of brains are observed in the rats exposed to arsenic. These effects were more prominent in aged rats in comparison to young rats. Melatonin successfully attenuates arsenic induced adverse effects on the brain in both age groups. In conclusion, our study shows that melatonin has significant ameliorative impact on age‐dependent cytotoxicity of arsenic in rats' brains.

show abstract

“…82 In sub-chronic arsenic-induced animals, exogenous melatonin administration exerts properties of scavenging oxidative and nitrosative radicals, inhibiting pro-inflammatory cytokines and repairing neuropharmacological disturbance. 83 The hyperalgesic and inflammatory responses induced by CFA could be effectively attenuated by melatonin. 84 In an animal model of oxaliplatin-induced pain, melatonin alleviates nociceptive response via repression of glial fibrillary acidic protein (GFAP) and inflammatory cytokines such as IL-1 and TNFα, and neuropathic deficits via reduction of the loss of mitochondrial membrane potential.…”

Section: Chronic Inflammatory Painmentioning

confidence: 99%

<p>Role of Melatonin in the Regulation of Pain</p>

Xie

Fan

et al. 2020

JPR

View full text Add to dashboard Cite

Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine recent evidence for melatonin on pain regulation in various animal models and patients with pain syndromes, and the potential cellular mechanisms.

show abstract

Melatonin Ameliorates Neuropharmacological and Neurobiochemical Alterations Induced by Subchronic Exposure to Arsenic in Wistar Rats

Cited by 16 publications

References 68 publications

Curcumin alleviates Arsenic trioxide-induced behavioural impairment, oxidative damage & morphological alterations in striatal region of mice brain

Curcumin alleviates Arsenic trioxide-induced behavioural impairment, oxidative damage & morphological alterations in striatal region of mice brain

Molecular mechanisms underlying ameliorative impact of melatonin against age‐dependent chronic arsenic toxicity in rats' brains

<p>Role of Melatonin in the Regulation of Pain</p>

Contact Info

Product

Resources

About