Melatonin and 6-sulfatoxymelatonin circadian rhythms in serum and urine of primary prostate cancer patients: Evidence for reduced pineal activity and relevance of urinary determinations

Lack of Association of the NPAS2 Gene Ala394Thr Polymorphism (rs2305160:G>A) with Risk of Chronic Lymphocytic Leukemia

“…The current study showed low melatonin levels in CLL patients compared to their healthy controls. This observation is in agreement with other studies that also provide evidence for low levels of melatonin as risk factors in other cancers (Bartsch et al, 1992;Schernhammer and Hankinson, 2009). Current study also reports low melatonin levels in shift-workers as compared to non-shift-workers within the CLL group Mirick and Davis (2008) proposed that circulating melatonin levels can be considered as a biomarker of circadian disruption and has been associated with nightshift-work and exposure to light-at-night.…”

Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance

“…Mean value and amplitude were significantly depressed by 40-60% in with primary prostate cancer (40-60%) as compared to the other groups. Circadian rhythms similar to those of serum were found in urine [224] 138 women (68 were diagnosed with endometrial cancer, 70 had abnormal bleeding¡…”

Does “Clock” Matter in Prostate Cancer?

“…This hypothesis was based on a light-atnight suppression of melatonin (8). Analogously, melatonin has been reported to be lower in men with prostate cancer than those without (9) and melatonin has been shown in vitro to modulate prostate cancer cell growth via androgen receptor interactions (10). The clock-cancer connection has gained some very limited but consistent support from previous studies.…”