Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis

Lowes, Damon A.; AlMawash, Amjad; Webster, Nigel R.; Reid, Victoria; Galley, Helen F.

doi:10.1093/bja/aer149

Cited by 62 publications

(63 citation statements)

References 41 publications

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“…Melatonin possesses marked anti-inflammatory properties (Dugo et al, 2001;Sener et al, 2005;Yavuz et al, 2007;Wu et al, 2008;Lowes et al, 2011;Agil et al, 2013;Mauriz et al, 2013). This action of melatonin contributes to its ability to attenuate tissue damage under a variety of conditions including neurodegenerative diseases where inflammatory responses are frequently a serious component of these conditions.…”

Section: Melatoninmentioning

confidence: 99%

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Ramis

Esteban

Miralles

et al. 2015

Mechanisms of Ageing and Development

145

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Section: Melatoninmentioning

confidence: 99%

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Ramis

Esteban

Miralles

et al. 2015

Mechanisms of Ageing and Development

145

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“…This is referred to as the free radical avoidance reaction of melatonin [61]. Not only melatonin per se but several of its metabolites including 2-hydroxylmelatonin, 6-hydroxylmelatonin, cyclic 3-hydroxymelatonin, N 1 -acetyl- N 2 -fomyl-5-methoxykynuramine (AFMK), and N 1 -acetyl-5-methoxykynuramine (AMK) are also antioxidants [20,62,63,64,65,66,67,68]. Cyclic 3-hydroxymelatonin and AMK were reported to be more potent than melatonin toward their reaction with ROS [69,70,71,72,73].…”

Section: Introductionmentioning

confidence: 99%

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

Tan

Manchester

Qin

et al. 2016

IJMS

322

256

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Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N-acetyltransferase (AANAT/SNAT) is localized in mitochondria of oocytes and the isolated mitochondria generate melatonin. We have also speculated that melatonin is a mitochondria-targeted antioxidant. It accumulates in mitochondria with high concentration against a concentration gradient. This is probably achieved by an active transportation via mitochondrial melatonin transporter(s). Melatonin protects mitochondria by scavenging reactive oxygen species (ROS), inhibiting the mitochondrial permeability transition pore (MPTP), and activating uncoupling proteins (UCPs). Thus, melatonin maintains the optimal mitochondrial membrane potential and preserves mitochondrial functions. In addition, mitochondrial biogenesis and dynamics is also regulated by melatonin. In most cases, melatonin reduces mitochondrial fission and elevates their fusion. Mitochondrial dynamics exhibit an oscillatory pattern which matches the melatonin circadian secretory rhythm in pinealeocytes and probably in other cells. Recently, melatonin has been found to promote mitophagy and improve homeostasis of mitochondria.

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“…Melatonin treatment prevents mitochondrial impairment and inhibits inducible mitochondrial NOS activity in septic mice [34,35]. The study presented by Lowes et al also supports that melatonin reduces the production of IL-6 and IL-8, and prevents the loss of mitochondrial membrane potential in endothelial cells treated with LPS plus peptidoglycan G (PepG) [36]. Recently, they further proved that in vivo melatonin i.v.…”

Section: Introduction Of Melatoninmentioning

confidence: 94%

Modulation by Melatonin of the Pathogenesis of Inflammatory Autoimmune Diseases

Lin

Huang

Chen

et al. 2013

IJMS

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Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal rhythms, and antioxidant and anti-inflammatory effects. It also possesses the ability to modulate immune responses by regulation of the T helper 1/2 balance and cytokine production. Autoimmune diseases, which result from the activation of immune cells by autoantigens released from normal tissues, affect around 5% of the population. Activation of autoantigen-specific immune cells leads to subsequent damage of target tissues by these activated cells. Melatonin therapy has been investigated in several animal models of autoimmune disease, where it has a beneficial effect in a number of models excepting rheumatoid arthritis, and has been evaluated in clinical autoimmune diseases including rheumatoid arthritis and ulcerative colitis. This review summarizes and highlights the role and the modulatory effects of melatonin in several inflammatory autoimmune diseases including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, and inflammatory bowel disease.

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Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis

Cited by 62 publications

References 41 publications

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

Modulation by Melatonin of the Pathogenesis of Inflammatory Autoimmune Diseases

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