Melatonin as an antioxidant: The main functions and properties

Bespyatykh, A. Yu.; Burlakova, O. V.; Голиченков, В. А.

doi:10.1134/s2079086411020022

Cited by 5 publications

(3 citation statements)

References 78 publications

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“…Most circulating melatonin is metabolized in the liver into 6-hydroxymelatonin and then into 6-sulfatoxymelatonin (aMT6s), which is excreted with urine. The concentrations of epiphyseal melatonin and aMT6s in the urine are in direct correlation [ 16 , 17 , 18 ]. The concentration of aMT6s was measured in urine collected in the daytime (07:00 h–19:00 h) and nighttime (19:00 h–07:00 h) periods using a 6-Sulfatoxymelatonin ELISA (Buhlmann Laboratories AG, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

et al. 2022

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Artificial light is characterized by certain features of its impact on the body in terms of its spectral distribution of power, duration of exposure and intensity. Short waves, perceived as blue light, are the strongest synchronizing agent for the circadian system. In the present work, we investigated the features of the circadian rhythms of blood pressure (BP), heart rate (HR), the excretion of electrolytes and the secretion of melatonin in normotensive (Wistar–Kyoto) and hypertensive (SHR) rats under the action of monochromatic blue light in the daytime period. It was found that the exposure of Wistar–Kyoto rats to monochromatic blue light was accompanied by a significant decrease in nighttime and 24h systolic BP. The most remarkable changes are characteristic of the HR in SHR rats under monochromatic light. A significant decrease in HR in each time period was found, but the predominance of nighttime over daytime values remained in SHR animals. There was also a significant increase in the mesor of the HR in SHR rats. Additionally, the amplitude of diastolic BP and HR, as well as the range of oscillations in HR, were significantly increased compared with the standard light pattern. In contrast to SHR rats, the regulation of the circadian rhythms in Wistar–Kyoto rats was more flexible and presented more changes, which may be aimed at the adaptation of the body to environmental conditions. For Wistar–Kyoto rats, an increase in the level of excreted electrolytes was observed under the action of monochromatic light, but no similar changes were found in SHR rats. For Wistar–Kyoto rats, a significant decrease in the urine concentration of aMT6s in the daytime and nighttime periods is characteristic, which results in the loss of the circadian rhythm. In SHR rats, there was a significant decrease in the nighttime content of aMT6s in the urine, while the daytime concentration, on the contrary, increased. The obtained data demonstrate that prolonged exposure to monochromatic blue light in the daytime period affects the circadian structure of the rhythms of the cardiovascular system, the rhythm of electrolyte excretion and the production of epiphyseal melatonin in wild-type and hypertensive animals. In SHR rats, the rhythms of BP and HR exhibit a more rigid pattern.

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Section: Methodsmentioning

confidence: 99%

Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

et al. 2022

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“…Melatonin can serve as an antioxidant in two ways; actively by scavenging free radicals and passively by enhancing the activity of key antioxidant enzymes. Melatonin possesses both direct and indirect anticancer effects 4 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients

Qadir,

Karatepe,

Yazici

et al. 2024

Bio. Med. Tar. Jour.

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Metabolites and antioxidants can be altered in patients with various diseases, particularly in those with cancer. This study aims to measure melatonin and total antioxidant levels in the serum of breast cancer patients and compare them with a healthy control group. Both groups had serum samples collected at 2:00 a.m. and 9:00 a.m. Melatonin levels were determined using High-performance liquid chromatography (HPLC), while total antioxidant levels were assessed by Enzyme-linked immunosorbent assay (ELISA). Levels of melatonin and total antioxidants differed between the groups. In the control group, the levels of melatonin and total antioxidants were considerably greater compared to the diagnostic group, with a p-value of 0.001. Melatonin and total antioxidant levels were consistently greater at 2:00 than at 9:00. The maximum melatonin levels recorded in the diagnostic and control groups were 39.3 pg/mL and 65.9 pg/mL, respectively. Melatonin levels varied based on the age of the participants, with higher amounts observed in younger participants compared to older people in both groups. The BMI affected the levels of melatonin, with a greater BMI leading to elevated melatonin concentrations. The diagnostic group had a total antioxidant level of 39.3 pg/mL, while the control group had a level of 65.9 pg/mL. The elevated levels of melatonin and total antioxidants in the control group indicate a healthy status. The research demonstrated a significant correlation between melatonin and antioxidant levels in breast cancer patients, with reduced melatonin levels and total antioxidant levels in the diagnosed group. Elevated BMI was linked to reduced melatonin levels.

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“…Melatonin is an indole derivative of serotonin and follows it in the chain of biosynthesis reactions taking place in many organs, including, for example, enterochromaffin cells of the digestive tract [54]. Melatonin acts as a main regulator of biological rhythms, participates in the transmission of information on light conditions of the external environment to the internal environment of the organism, has antioxidant, cytoprotective, adaptogenic, and immunomodulatory effects [55][56][57][58]. Among the many factors impacting the genesis of the motility and evacuation disorders in the upper gastrointestinal tract, disorders of neurohumoral regulation are of particular importance.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

Kamarchuk¹,

Pospelov²,

Harbuz³

et al. 2021

J. Breath Res.

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Significant progress in development of noninvasive diagnostic tools based on breath analysis can be expected if one employs a real-time detection method based on finding a spectral breath profile which would contain some energy characteristics of the analyzed gas mixture. Using the fundamental energy parameters of a quantum system, it is possible to determine with a high accuracy its quantitative and qualitative composition. Among the most efficient tools to measure energy characteristics of quantum systems are sensors based on Yanson point contacts. This paper reports the results of serotonin and melatonin detection as an example of testing the human hormonal background with point-contact sensors, which have already demonstrated their high efficiency in detecting carcinogenic strains of Helicobacter pylori and selective detection of complex gas mixtures. When comparing the values of serotonin and melatonin with the characteristic parameters of the spectral profile of the exhaled breath of each patient, high correlation dependences of the concentration of serotonin and melatonin with a number of characteristic parameters of the response curve of the point-contact sensor were found. The performed correlation analysis was complemented with the regression analysis. As a result, empiric regression relations were proposed to realize in practice the new non-invasive breath test for evaluation of the human hormonal background. Registration of the patient’s breath profile using point-contact sensors makes it possible to easily monitor the dynamics of changes in the human hormonal background and perform a quantitative evaluation of serotonin and melatonin levels in the human body in real time without invasive interventions (blood collection) and expensive equipment or reagents.

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Melatonin as an antioxidant: The main functions and properties

Cited by 5 publications

References 78 publications

Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients

Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

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