Melatonin attenuates behavioural deficits and reduces brain oxidative stress in a rodent model of schizophrenia

Cyclophosphamide-induced male subfertility in mice: An assessment of the potential benefits of Maca supplement

“…GSH activity was determined by absorbance at 412 nm and expressed as ng of GSH/g (Onaolapo, Aina, & Onaolapo, 2017a). This was based on Ellman's reagent's (DTNB) reaction with free thiol groups.…”

“…GSH activity was determined by absorbance at 412 nm and expressed as ng of GSH/g (Onaolapo, Aina, & Onaolapo, 2017a). Superoxide dismutase levels were assayed based on the enzyme's ability to inhibit the phenazine methosulphate mediated reduction in nitro blue tetrazolium dye, the change in absorbance at 560 nm over 5 min was measured (Onaolapo, Onaolapo, & Nwoha, 2017b).…”

Melatonin, adolescence, and the brain: An insight into the period‐specific influences of a multifunctional signaling molecule

“…Its use is supported by studies that confirm a strong association between low early‐morning serum melatonin levels and sleep disturbances in adolescents (Inigo, Lestari, Masloman, & Lolombulan, ). In humans, irrespective of age, the most widely studied aspect of exogenous melatonin administration is perhaps in relation to sleep promotion or management of sleep disorders; however, in rodents, several studies have reported beneficial effects on several aspects of behavior (El Mrabet et al, ; Mantovani, Pertile, Calixto, Santos, & Rodrigues, ; Onaolapo, Adebayo, et al, ; Onaolapo, Aina et al, ; Yildirim & Marangoz, ), and also deleterious effects like impairment of acquisition, but not the expression of contextual fear in rats (Yang, Li, & Huang, ), proconvulsant effects (Stewart & Leung, ), and suppression of night‐time memory formation (Rawashdeh, de Borsetti, Roman, & Cahill, ).…”

“…However, some studies have reported no significant improvement in behavior, mood, or cognition (Van der Heijden et al, ). In two studies from our laboratory, we reported the mitigation of behavioral alterations secondary to exposure to physical stressors or chemically induced schizophrenia‐like behaviors in mice (Onaolapo, Adebayo, et al, ; Onaolapo, Aina, et al, ). Administration of exogenous melatonin during daylight modulated behavioral response to physical stress during the adolescent period in mice, as its administration was associated with a reversal of the behavioral (locomotor activity, self‐grooming, anxiety‐related behaviors, and memory) and systemic effects of exposure of mice to chronic unpredictable stress (Onaolapo, Adebayo, et al, ).…”

“…In humans or rodents, melatonin is also known to influence numerous biologic processes, such as locomotion (Onaolapo, Adebayo, & Onaolapo, ), memory formation (He et al, ; Onaolapo, Onaolapo, Akanni, & Eniafe, ), anxiety (Comai & Gobbi, ; Onaolapo, Adebayo, et al, ), depression (El Mrabet, Ouakki, Mes_Oui, El Hessni, & Ouichou, ), nociception (Yoon et al, ), and control of body posture and balance (Fraschini, Cesarani, Alpini, Esposti, & Stankov, ). Melatonin plays important roles in neurogenesis (Tocharus et al, ), neuroprotection (Pandi‐Perumal et al, ), maintenance of oxidant/antioxidant balance (Onaolapo, Aina, & Onaolapo, ), modulation of cardiovascular and/or immune system (Sánchez‐Barceló, Mediavilla, Tan, & Reiter, ), and diabetes control (Lyssenko et al, ). It also exerts a direct antioxidant effect on tissues/organs (Ekmekcioglu, ), and antiapoptotic effects on cells (Luchetti et al, ).…”