Melatonin can attenuate ciprofloxacin induced nephrotoxicity: Involvement of nitric oxide and TNF-α

Shaki, Fatemeh; Ashari, Sorour; Ahangar, Nematollah

doi:10.1016/j.biopha.2016.10.053

Cited by 25 publications

(12 citation statements)

References 48 publications

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“…They showed that MEL ameliorates the depletion of GSH, GPx and alkaline phosphatase activity and reduces the level of lipid peroxidation in different organs such as brain, spleen, testes and kidney. Moreover, it has been shown that MEL is able to prevent renal impairment induced by ciprofloxacin in rats via inhibition of inflammation and oxidative damage [56]. Furthermore, MEL ameliorates nephropathy in diabetic rats' kidneys via attenuation of oxidative stress [57].…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Goudarzi

Khodayar

Tabatabaei

et al. 2017

Fundamemntal Clinical Pharma

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Cyclophosphamide (CP) is widely used in treatment of different cancers. Nephrotoxicity is one of the dose-limiting side effects of CP. This study was carried out to investigate the effect of melatonin (MEL) on CP-induced nephrotoxicity in mice. In this study, 50 Swiss albino mice (20-25 g) were randomly divided into five groups. Mice were pretreated with MEL intraperitoneally (i.p) in doses of 5, 10 and 20 mg/kg for five consecutive days, and CP (200 mg/kg, i.p) was administrated on the 5th day 1 h after the last dose of MEL. Then on day 6, blood samples were collected to determine serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The kidneys were used for histological examination, biochemical assays and real-time PCR studies. Malondialdehyde (MDA), glutathione (GSH), protein carbonyl (PC), nitric oxide (NO) level, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and myeloperoxidase (MPO) activity were assessed in renal tissue. In addition, the expression of SOD2 and PGx1 was measured using real-time PCR method in renal tissue. Results showed that CP administration significantly increases Cr, BUN, MDA, PC, NO level and MPO activity. It also decreases renal GSH level, SOD, GPx and CAT activity. Pretreatment with MEL (especially 20 mg/kg, i.p.) for 5 days prevented these changes; however, it did not affect the SOD activity. Our results revealed that MEL might be useful for prevention of the nephrotoxicity induced by CP through ameliorative effects on biochemical indices and oxidative stress parameters.

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Section: Discussionmentioning

confidence: 99%

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Goudarzi

Khodayar

Tabatabaei

et al. 2017

Fundamemntal Clinical Pharma

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“…The impairment in kidney function markers following ciprofloxacin administration had been documented in Hafiz et al [32] who mentioned that ciprofloxacin treatment was an offending agent causing an increase in serum lactate dehydrogenase and serum creatinine among other adverse effects. Moreover, Shaki et al, [33] reported that ciprofloxacin showed an oxidative damage and inflammation with marked nephrotoxicity, represented by increase in serum BUN and creatinine with histopathological changes.…”

Section: Levofloxacinmentioning

confidence: 99%

Some Pharmacological Studies of Ciproflo

Abdel-Alim

Kamel

Elsayed

2017

Zagazig Veterinary Journal

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This study was conducted to investigate some pharmacological effects of ciprofloxacin and levofloxacin in their therapeutic and double therapeutic doses on healthy male albino rats. Forty five rats were divided into 5 groups, each of 9 rats, 1 st was left as a control, 2 nd and 3 rd groups received 100 mg/kg BW ciprofloxacin and levofloxacin respectively, orally for 10 successive days (therapeutic dose). The 4 th and 5 th groups were administrated 200 mg/kg ciprofloxacin and levofloxacin respectively, orally for 10 successive days (double therapeutic doses). Urine analysis and serum biochemical parameters were estimated in addition to histopathological examination of liver and kidneys. The urine analysis revealed that levofloxacin at its therapeutic and double therapeutic doses produced a significant increase in urinary proteins, blood, bilirubin, urobilinogen and urinary ketones while ciprofloxacin doses produced less damage. However, serum biochemical parameters disclosed that levofloxacin is a safer fluoroquinolone than ciprofloxacin; these results were confirmed by histopathological examination of liver and kidneys. Urine analysis despite widely used in human laboratories, it is not a reliable technique; blood biochemical parameters examination and histopathological examination are more dependable.

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“…TNF-α plays a fundamental role in the pathological changes seen in failing hearts, such as ventricular remodeling, cardio fibrosis and apoptosis [ 23 24 25 ]. While our data demonstrate that protein expression of TNF-α was elevated in failing hearts, that the increase in TNF-α was not reversed by melatonin treatment.…”

Section: Discussionmentioning

confidence: 99%

The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs

Luo³

et al. 2018

Korean J Physiol Pharmacol

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The effect of melatonin on juveniles with cardio fibrosis is poorly understood. We investigated whether HDACs participate in the anti-fibrotic processes regulated by melatonin during hypertrophic remodeling. Abdominal aortic constriction (AAC) was employed in juvenile rats resulting in pressure overload-induced ventricular hypertrophy and melatonin was subsequently decreased via continuous light exposure for 5 weeks after surgery. AAC rats displayed an increased cross-sectional area of myocardial fibers and significantly elevated collagen deposition compared to sham-operated rats, as measured by HE and Masson Trichrome staining. Continuous light exposure following surgery exacerbated the increase in the cross-sectional area of myocardial fibers. The expression of HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 genes were all significantly enhanced in AAC rats with light exposure relative to the other rats. Moreover, the protein level of TNF-α was also upregulated in the AAC light exposure groups when compared with the sham. However, Smad4 protein expression was unchanged in the juveniles' hearts. In contrast, beginning 5 weeks after the operation, the AAC rats were treated with melatonin (10 mg/kg, intraperitoneal injection every evening) or vehicle 4 weeks, and sham rats were given vehicle. The changes in the histological measures of cardio fibrosis and the gene expressions of HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 were attenuated by melatonin administration. The results reveal that melatonin plays a role in the development of cardio fibrosis and the expression of HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 in cardiomyocytes.

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Melatonin can attenuate ciprofloxacin induced nephrotoxicity: Involvement of nitric oxide and TNF-α

Cited by 25 publications

References 48 publications

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Some Pharmacological Studies of Ciproflo

The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs

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