Melatonin confers plant tolerance against cadmium stress via the decrease of cadmium accumulation and reestablishment of microRNA-mediated redox homeostasis

Gu, Quan; Chen, Ziping; Yu, Xianxian; Cui, Weiti; Pan, Jun; Zhao, Guang‐Chao; Xu, Sheng; Ren, Wang; Shen, Wenbiao

doi:10.1016/j.plantsci.2017.05.001

Cited by 191 publications

(118 citation statements)

References 49 publications

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“…Exogenously applied MEL appreciably reduced cadmium (Cd) content in the leaves of tomato via modulating the activities of H + ‐ATPase activity, glutathione content, and phytochelatins, documenting its active involvement in the translocation of Cd metal ions in plants . Pretreatment with MEL not only increased endogenous phytomelatonin content, but also decreased Cd accumulation via modulating the activity of heavy metal transporters . In a comparative analysis, the effects of MEL on growth and Cd uptake in Malachium aquaticum (Cd accumulator) and Galinsoga parviflora (hyperaccumulator) were observed .…”

Section: Mel Prospects In Phytoremediationmentioning

confidence: 99%

Phytomelatonin: Recent advances and future prospects

Kanwar

Zhou

2018

Journal of Pineal Research

175

109

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Melatonin (MEL) has been revealed as a phylogenetically conserved molecule with a ubiquitous distribution from primitive photosynthetic bacteria to higher plants, including algae and fungi. Since MEL is implicated in numerous plant developmental processes and stress responses, the exploration of its functions in plant has become a rapidly progressing field with the new paradigm of involvement in plants growth and development. The pleiotropic involvement of MEL in regulating the transcripts of numerous genes confirms its vital involvement as a multi‐regulatory molecule that architects many aspects of plant development. However, the cumulative research in plants is still preliminary and fragmentary in terms of its established functions compared to what is known about MEL physiology in animals. This supports the need for a comprehensive review that summarizes the new aspects pertaining to its functional role in photosynthesis, phytohormonal interactions under stress, cellular redox signaling, along with other regulatory roles in plant immunity, phytoremediation, and plant microbial interactions. The present review covers the latest advances on the mechanistic roles of phytomelatonin. While phytomelatonin is a sovereign plant growth regulator that can interact with the functions of other plant growth regulators or hormones, its qualifications as a complete phytohormone are still to be established. This review also showcases the yet to be identified potentials of phytomelatonin that will surely encourage the plant scientists to uncover new functional aspects of phytomelatonin in plant growth and development, subsequently improving its status as a potential new phytohormone.

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Section: Mel Prospects In Phytoremediationmentioning

confidence: 99%

Phytomelatonin: Recent advances and future prospects

Kanwar

Zhou

2018

Journal of Pineal Research

175

109

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“…Melatonin is critical for Cd detoxification. Therefore, exogenous melatonin has been applied to Cd-stressed herbaceous plants such as tomato (Hasan et al 2015), rice (Byeon et al 2015), wheat (Ni et al 2018, Kaya et al 2019, and alfalfa (Gu et al 2017) in an attempt to enhance their Cd tolerance. To our knowledge, however, there are no studies on the efficacy of exogenous melatonin in enhancing Cd detoxification in woody fruit crops or the putative mechanisms involved.…”

mentioning

confidence: 99%

“…Vacuole-sequestered HMs, including Cd, may be remobilized via the tonoplast-localized metal efflux transporter NRAMP3 and transported into the apoplast by PM-localized transporters such as HM ATPase 4 (HMA4) and plant cadmium resistance protein 2 (PCR2), which are critical for Cd translocation from the roots to the shoots (Thomine et al 2000, Verret et al 2004, Song et al 2010, Lin and Aarts 2012. Exogenous melatonin upregulated ABC transporter and PCR2 in alfalfa, and HMA4 in Arabidopsis (Gu et al 2017). To the best of our knowledge, however, there is no information on the transcriptional regulation of the genes governing melatonin-mediated Cd uptake, translocation, and tolerance in apple trees.…”

mentioning

confidence: 99%

Exogenous melatonin alleviates cadmium uptake and toxicity in apple rootstocks

Zhuang

Zhou

et al. 2020

Tree Physiology

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To examine the potential roles of melatonin in Cd uptake, accumulation and detoxification in Malus plants, we exposed two different apple rootstocks varying greatly in Cd uptake and 2 accumulation to either 0 or 30 μM Cd together with 0 or 100 μM melatonin. Cd stress stimulated endogenous melatonin production to a greater extent in the Cd-tolerant M. baccata than in the Cd-susceptible M. micromalus "qingzhoulinqin". Melatonin application attenuated Cd-induced reductions in growth, photosynthesis, and enzyme activity, as well as ROS and MDA accumulation. Melatonin treatment more effectively restored photosynthesis, photosynthetic pigments, and biomass in Cd-challenged M. micromalus "qingzhoulinqin" than in Cd-stressed M. baccata. Exogenous melatonin lowered root Cd 2+ uptake, reduced leaf Cd accumulation, decreased Cd translocation factors (T f s), and increased root, stem, and leaf melatonin contents in both Cd-exposed rootstocks. Melatonin application increased both antioxidant concentrations and enzyme activities to scavenge Cd-induced ROS. Exogenous melatonin treatment altered the mRNA levels of several genes regulating Cd uptake, transport, and detoxification including HA7, NRAMP1, NRAMP3, HMA4, PCR2, NAS1, MT2, ABCC1, and MHX. Taken together, these results suggest that exogenous melatonin reduced aerial parts Cd accumulation and mitigated Cd toxicity in Malus plants, probably due to the melatonin-mediated Cd allocation in tissues, and induction of antioxidant defense system and transcriptionally regulated key genes involved in detoxification.

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“…Excessive ROS accumulation leads to oxidative stress that causes damage to DNA, RNA, and enzymes. In order to cope with oxidative stress, plants have evolved different mechanisms which includes production of antioxidants such as catalase, peroxidase, superoxide dismutase, ascorbate peroxidase, glutathione reductase, monodehydro‐ascorbate reductase (MDHAR) and non‐enzymatic antioxidants such as ascorbate (AsA), carotenoids, flavonoids, and vitamin E . However, melatonin is considered as first line of defense against oxidative stress that either directly scavenge ROS or increase biosynthesis of other antioxidants or enhance activities of other antioxidants .…”

Section: Functions Of Melatonin and Pgpr In Plantsmentioning

confidence: 99%

“…Transgenic Arabidopsis over expressing SNAT gene of alfalfa is found to produce more melatonin than wild plants thus alleviating Cd stress. In transgenic Arabidopsis , transporter genes pleiotropic drug resistance 8 ( PDR8 ) and heavy metal ATPase 4 ( HMA4 ) were up‐regulated while Nramp6 was down‐regulated . Melatonin application under Cd stress enhances phytochelatin biosynthesis, antioxidant potential, and Cd sequestration in tomato.…”

Section: Functions Of Melatonin and Pgpr In Plantsmentioning

confidence: 99%

Role of Melatonin and Plant‐Growth‐Promoting Rhizobacteria in the Growth and Development of Plants

Asif

Pervez

Ahmad

2019

CLEAN Soil Air Water

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Melatonin is a tryptophan‐based indole molecule found in primitive photosynthetic bacteria to mammals. It performs different functions in plants like rhizogenesis, enhancing plant growth, seed germination, plant yield, biomass production, photosynthesis, circadian rhythm, and fruit ripening. In addition, one of the most significant attributes of melatonin is its antioxidant activity. Moreover, it works as an anti‐stress agent against different biotic and abiotic stresses like drought, salinity, potentially toxic metals, and pathogens. Melatonin forms antioxidant cascade reaction by scavenging free radicals that enhances its antioxidant capacity. In response to different stress conditions, expression of genes involved in melatonin synthesis is increased. In the same way, plant‐growth‐promoting rhizobacteria colonize plant roots and enhance plant growth by a number of mechanisms like phosphate solubilization, nitrogen fixation, siderophore production, production of phytohormones, phytoremediation, disease suppression, and production of 1‐aminocyclopropane‐1‐carboxylate deaminase. Thus, melatonin and plant‐growth‐promoting rhizobacteria are involved in enhancing plant growth under abiotic and biotic stress but the mechanisms of action of both are different. Therefore, in this study, the data on the impact of melatonin and plant‐growth‐promoting rhizobacteria on plants are combined for the first time and how these could be useful in enhancing the plant growth is examined. In addition, the research gaps are identified in melatonin and plant‐growth‐promoting rhizobacteria research already conducted from the last few decades that will help the scientific community in further research.

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Melatonin confers plant tolerance against cadmium stress via the decrease of cadmium accumulation and reestablishment of microRNA-mediated redox homeostasis

Cited by 191 publications

References 49 publications

Phytomelatonin: Recent advances and future prospects

Phytomelatonin: Recent advances and future prospects

Exogenous melatonin alleviates cadmium uptake and toxicity in apple rootstocks

Role of Melatonin and Plant‐Growth‐Promoting Rhizobacteria in the Growth and Development of Plants

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