Melatonin does not React Rapidly with Hydrogen Peroxide

Grzelak, Agnieszka; Macierzyńska, Ewa; Bartosz, Grzegorz

doi:10.1080/10715760412331272486

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…An activity monitor has been used to show that flies over-expressing catalase maintain activity for a longer period when challenged with toxic concentrations of hydrogen peroxide [41]. Melatonin has been identified as a circadian rhythm regulator in mammals, and has been reported to act as a scavenger of several different ROS [42], including hydrogen peroxide [43] (but see also [44]). Circadian variation in SOD enzyme activity is observed in primate erythrocytes [45].…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster

et al. 2009

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Circadian rhythms in animals are regulated at the level of individual cells and by systemic signaling to coordinate the activities of multiple tissues. The circadian pacemakers have several physiological outputs, including daily locomotor rhythms. Several redox-active compounds have been found to function in regulation of circadian rhythms in cells, however, how particular compounds might be involved in regulating specific animal behaviors remains largely unknown. Here the effects of hydrogen peroxide on Drosophila movement were analyzed using a recently developed three-dimensional real-time multiple fly tracking assay. Both hydrogen peroxide feeding and direct injection of hydrogen peroxide caused increased adult fly locomotor activity. Continuous treatment with hydrogen peroxide also suppressed daily locomotor rhythms. Conditional over-expression of the hydrogen peroxide-producing enzyme superoxide dismutase (SOD) also increased fly activity and altered the patterns of locomotor activity across days and weeks. The real-time fly tracking system allowed for detailed analysis of the effects of these manipulations on behavior. For example, both hydrogen peroxide feeding and SOD over-expression increased all fly motion parameters, however, hydrogen peroxide feeding caused relatively more erratic movement, whereas SOD over-expression produced relatively faster-moving flies. Taken together, the data demonstrate that hydrogen peroxide has dramatic effects on fly movement and daily locomotor rhythms, and implicate hydrogen peroxide in the normal control of these processes.

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Section: Discussionmentioning

confidence: 99%

Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster

et al. 2009

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“…This claim is based on the apparent loss of H 2 O 2 with increasing melatonin as determined by HRP-catalyzed oxidation of Phenol Red. However, this effect likely resulted from a separate melatonin effect on the HRP-catalyzed reaction because direct analysis of H 2 O 2 in the absence HRP refuted these results [147].…”

Section: -Hydroethidiummentioning

confidence: 94%

Use of spectroscopic probes for detection of reactive oxygen species

Bartosz

2006

Clinica Chimica Acta

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271

174

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“…Notably, H 2 O 2 is relatively week oxidant, unless following metal-dependent production to hydroxyl radical (OH·). Importantly, melatonin is able to directly scavenge highly toxic OH· [76], but does not react with its precursor—H 2 O 2 [77]. Thus, direct scavenging of H 2 O 2 by melatonin has negligible significance, but it is possible that melatonin in mitochondria detoxifies H 2 O 2 due to cytochrome c -dependent pseudoperoxidase reaction, as described below.…”

Section: Melatonin–mitochondria Axis In the Skinmentioning

confidence: 99%

Melatonin, mitochondria, and the skin

Słomiński

Żmijewski

Semak

et al. 2017

Cell. Mol. Life Sci.

166

146

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The skin being a protective barrier between external and internal (body) environments has the sensory and adaptive capacity to maintain local and global body homeostasis in response to noxious factors. An important part of the skin response to stress is its ability for melatonin synthesis and subsequent metabolism through the indolic and kynuric pathways. Indeed, melatonin and its metabolites have emerged as indispensable for physiological skin functions and for effective protection of a cutaneous homeostasis from hostile environmental factors. Moreover, they attenuate the pathological processes including carcinogenesis and other hyperproliferative/inflammatory conditions. Interestingly, mitochondria appear to be a central hub of melatonin metabolism in the skin cells. Furthermore, substantial evidence has accumulated on the protective role of the melatonin against ultraviolet radiation and the attendant mitochondrial dysfunction. Melatonin and its metabolites appear to have a modulatory impact on mitochondrion redox and bioenergetic homeostasis, as well as the anti-apoptotic effects. Of note, some metabolites exhibit even greater impact than melatonin alone. Herein, we emphasize that melatonin–mitochondria axis would control integumental functions designed to protect local and perhaps global homeostasis. Given the phylogenetic origin and primordial actions of melatonin, we propose that the melatonin-related mitochondrial functions represent an evolutionary conserved mechanism involved in cellular adaptive response to skin injury and repair.

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Melatonin does not React Rapidly with Hydrogen Peroxide

Cited by 3 publications

References 17 publications

Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster

Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster

Use of spectroscopic probes for detection of reactive oxygen species

Melatonin, mitochondria, and the skin

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