Melatonin Effects on Serum Cytokine Profiles of Rats with Different Behavioral Parameters in Acute Emotional Stress

Kalinichenko, L. S.; Перцов, С. С.; Коплик, Е. В.

doi:10.1007/s10517-014-2411-6

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…These conditions include physical and psychological stressful events like exercise, exposure to extreme thermal conditions, different kinds of pain, depression, sleep deprivation, hypoxia, etc. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. In general, an increased IL-10 level during these events is associated with better outcome and adaptation.…”

Section: Physiological and Nonimmune Conditionsmentioning

confidence: 99%

Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

Mingomataj

Bakiri

2015

Clinic Rev Allerg Immunol

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The interleukin-10 (IL-10) is generally considered as the most important cytokine with anti-inflammatory properties and one of the key cytokines preventing inflammation-mediated tissue damage. In this respect, IL-10 producing cells play a crucial role in the outcome of infections, allergy, autoimmune reactions, tumor development, and transplant tolerance. Based on recent findings with regard to the mentioned clinical conditions, this review attempts to shed some light on the IL-10 functions, considering this cytokine as inherent inducer of the switching immunity. While acute infections and vaccinations are associated by IL-10 enhanced during few weeks, chronic parasitoses, tumor diseases, allergen-specific immunotherapy, transplants, and use of immune-suppressor drugs show an increased IL-10 level along months or years. With regard to autoimmune pathologies, the IL-10 increase is prevalently observed during early stages, whereas the successive stages are characterized by reaching of immune equilibrium independently to disease's activity. Together, these findings indicate that IL-10 is mainly produced during transient immune conditions and the persistent IL-10-related effect is the indication/prediction (and maybe effectuation) of the switching immunity. Actual knowledge emphasizes that any manipulation of the IL-10 response for treatment purposes should be considered very cautiously due to its potential hazards to the immune system. Probably, the IL-10 as potential switcher of immunity response should be used in association with co-stimulatory immune effectors that are necessary to determine the appropriate deviation during treatment of respective pathologies. Hopefully, further findings would open new avenues to study the biology of this "master switch" cytokine and its therapeutic potential.

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Section: Physiological and Nonimmune Conditionsmentioning

confidence: 99%

Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

Mingomataj

Bakiri

2015

Clinic Rev Allerg Immunol

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“…We speculated that it was the high levels of serum proinflammatory cytokines which suppressed autophagy activity of PBMCs obtained from LPS-challenged transgenic animals. It has been reported that proinflammatory cytokines suppress autophagy activity [96][97][98] and several reports also report that melatonin elevates serum levels of some proinflammatory cytokines [99,100]. However, the exact mechanisms are currently unknown.…”

Section: Discussionmentioning

confidence: 99%

Effects of AANAT overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels

Tao

Yang

et al. 2018

Autophagy

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To explore the anti-inflammatory activity of endogenous produced melatonin, a melatonin-enriched animal model (goat) with AANAT transfer was successfully generated with somatic cell nuclear transfer (SCNT) technology. Basically, a pIRES2-EGFP-AANAT expression vector was constructed and was transferred into the female fetal fibroblast cells (FFCs) via electrotransfection and then the nuclear of the transgenic FFC was transferred to the eggs of the donor goats. The peripheral blood mononuclear cells (PBMCs) of the transgenic offspring expressed significantly higher levels of AANAT and melatonin synthetic function than those PBMCs from the wild-type (WT) animals. After challenge with lipopolysaccharide (LPS), the transgenic PBMCs had increased autophagosomes and LC3B expression while they exhibited suppressed production of the proinflammatory cytokines, IL1B and IL12 (IL12A-IL12B/p70), compared to their WT. The mechanistic analysis indicated that the anti-inflammatory activity of endogenous melatonin was mediated by MTNR1B (melatonin receptor 1B). MTNR1B stimulation activated the MAPK14 signaling pathway to promote cellular macroautophagy/autophagy, thus, suppressing the excessive inflammatory response of cellular. However, when the intact animals challenged with LPS, the serum proinflammatory cytokines were significantly higher in the transgenic goats than that in the WT. The results indicated that endogenous melatonin inhibited the MAPK1/3 signaling pathway and ROS production, subsequently downregulated gene expression of BECN1, ATG5 in PMBCs and then suppressed the autophagy activity of PBMCs and finally elevated levels of serum proinflammatory cytokines in transgenic animals, Herein we provided a novel melatonin-enriched animal model to study the potential effects of endogenously produced melatonin on inflammatory responses and autophagy activity.

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“…In terms of the role of IFN-γ in depression, conflicting results were reported. Although several studies demonstrated that CMS could result in a significant increase of IFN-γ in both the brain and periphery, it was also reported that either acute or chronic stress exposure would lead to a significant suppression of IFN-γ production [28][29][30][31]. These contrasting observations might be the result of the intertwined neuro-immune system.…”

Section: Discussionmentioning

confidence: 99%

Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats

Jiang

Zhang

Zhu

et al. 2014

J Endocrinol Invest

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Melatonin Effects on Serum Cytokine Profiles of Rats with Different Behavioral Parameters in Acute Emotional Stress

Cited by 10 publications

References 9 publications

Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

Effects of AANAT overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels

Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats

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