Melatonin for tinnitus

Ajayi, Olakunle V; Phillips, John S.; Laopaiboon, Malinee; McFerran, Don

doi:10.1002/14651858.cd011435

Cited by 2 publications

(1 citation statement)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, recent neuroscience studies imply that the moment-to-moment variability of tinnitus is related to brain oscillatory patterns like the alpha power in temporal regions (Schlee et al, 2014 ) and time-of-day (Basinou et al, 2017 ); circadian fluctuations have been shown, for example, in auditory pathway structures related to tinnitus like the cochlea (Meltser et al, 2014 ) and the inferior colliculus (Park et al, 2016 ). Another hint for a link between tinnitus and circadian rhythms is provided by findings of reduced tinnitus severity after intake of melatonin (e.g., Pirodda et al, 2010 ; Ajayi et al, 2014 ; Miroddi et al, 2015 ). Furthermore, pain, which shares many similarities with tinnitus (De Ridder et al, 2011 ; Rauschecker et al, 2015 ), has been found to underlie circadian variations (e.g., Strian et al, 1989 ; Gilron and Ghasemlou, 2014 ; Buttgereit et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Does Tinnitus Depend on Time-of-Day? An Ecological Momentary Assessment Study with the “TrackYourTinnitus” Application

Probst

Pryss

Langguth

et al. 2017

Front. Aging Neurosci.

View full text Add to dashboard Cite

Only few previous studies used ecological momentary assessments to explore the time-of-day-dependence of tinnitus. The present study used data from the mobile application “TrackYourTinnitus” to explore whether tinnitus loudness and tinnitus distress fluctuate within a 24-h interval. Multilevel models were performed to account for the nested structure of assessments (level 1: 17,209 daily life assessments) nested within days (level 2: 3,570 days with at least three completed assessments), and days nested within participants (level 3: 350 participants). Results revealed a time-of-day-dependence of tinnitus. In particular, tinnitus was perceived as louder and more distressing during the night and early morning hours (from 12 a.m. to 8 a.m.) than during the upcoming day. Since previous studies suggested that stress (and stress-associated hormones) show a circadian rhythm and this might influence the time-of-day-dependence of tinnitus, we evaluated whether the described results change when statistically controlling for subjectively reported stress-levels. Correcting for subjective stress-levels, however, did not change the result that tinnitus (loudness and distress) was most severe at night and early morning. These results show that time-of-day contributes to the level of both tinnitus loudness and tinnitus distress. Possible implications of our results for the clinical management of tinnitus are that tailoring the timing of therapeutic interventions to the circadian rhythm of individual patients (chronotherapy) might be promising.

show abstract

Section: Introductionmentioning

confidence: 99%

Does Tinnitus Depend on Time-of-Day? An Ecological Momentary Assessment Study with the “TrackYourTinnitus” Application

Probst

Pryss

Langguth

et al. 2017

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

A process for prioritising systematic reviews in tinnitus

Sereda

McFerran

Axon

et al. 2020

International Journal of Audiology

Self Cite

View full text Add to dashboard Cite

Objective: To develop an innovative prioritisation process to identify topics for new or updated systematic reviews of tinnitus research. Design:A two stage prioritisation process was devised. Firstly, a scoping review assessed the amount of randomised-controlled-trial-level evidence available. This enabled development of selection criteria for future reviews, aided the design of template protocol, and suggested the scale of work that would be required to conduct these reviews. Secondly, using the predefined primary and secondary criteria, interventions were prioritised for systematic review. Study sample:Searches identified 1080 records. After removal of duplicates and out of scope works, 437 records remained for full data charting. Results:The process was tested, using subjective tinnitus as the clinical condition and using Cochrane as the systematic review platform. The criteria produced by this process identified three high priority reviews: 1) Sound therapy using amplification devices and/or sound generators; 2) Betahistine, and 3) Cognitive Behaviour Therapy. Further secondary priorities were: 4) Gingko biloba, 5) Anxiolytics, 6) Hypnotics, 7) Antiepileptics, and 8) Neuromodulation. Conclusions:A process was developed which successfully identified priority areas for Cochrane systematic reviews of interventions for subjective tinnitus. This technique could easily be transferred to other conditions and other types of systematic reviews.

show abstract

Melatonin for tinnitus

Cited by 2 publications

References 67 publications

Does Tinnitus Depend on Time-of-Day? An Ecological Momentary Assessment Study with the “TrackYourTinnitus” Application

Does Tinnitus Depend on Time-of-Day? An Ecological Momentary Assessment Study with the “TrackYourTinnitus” Application

A process for prioritising systematic reviews in tinnitus

Contact Info

Product

Resources

About