Melatonin improves methanol intoxication‐induced oxidative liver injury in rats

Kurçer, Zehra; Oğuz, Eli̇f; Iraz, Mustafa; Fadıllıoğlu, Ersin; Baba, Füsun; Koksal, Mete; Ölmez, Ercüment

doi:10.1111/j.1600-079x.2007.00441.x

Cited by 28 publications

(22 citation statements)

References 46 publications

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“…As mentioned earlier, Galijasevic et al 47 have demonstrated that melatonin acts as a specific inhibitor of MPO under physiological conditions. Studies have shown that melatonin treatment prevents tissue injury by virtue of its ability to not only inhibit oxidative stress but also MPO activity 48,49 . Sener et al 50 have demonstrated that melatonin ameliorates ifosfamide induced renal dysfunction, GSH depletion, MDA accumulation and neutrophil infiltration.…”

Section: Discussionmentioning

confidence: 99%

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Abraham

Kolli

Rabi³

2010

Cell Biochemistry & Function

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Nephrotoxicity is an adverse side effect of methotrexate (MTX) chemotherapy. The present study verifies whether melatonin, an endogenous antioxidant prevents MTX-induced renal damage. Adult rats were administered 7 mg/kg body weight MTX intraperitoneally for 3 days. In the melatonin pretreated rats, 40 mg/ kg body weight melatonin was administered daily intraperitoneally 1 h before the administration of MTX. The rats were killed 12 h after the final dose of MTX/vehicle. The kidneys were used for light microscopic and biochemical studies. The markers of oxidative stress were measured along with the activities of the antioxidant enzymes and myeloperoxidase activity in the kidney homogenates. Pretreatment with melatonin reduced MTX induced renal damage both histologically and biochemically as revealed by normal plasma creatinine levels. Melatonin pretreatment reduced MTX induced oxidative stress, alteration in the activity of antioxidant enzymes as well as elevation in myeloperoxidase activity. The results suggest that melatonin has the potential to reduce MTX induced oxidative stress, neutrophil infiltration as well as renal damage. As melatonin is an endogenous antioxidant and is non-toxic even in high doses it is suggested that melatonin may be beneficial in minimizing MTX induced renal damage in humans.

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Section: Discussionmentioning

confidence: 99%

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Abraham

Kolli

Rabi³

2010

Cell Biochemistry & Function

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“…A strong antioxidant effect of melatonin seems evident as almost all investigators describe that in liver homogenates, melatonin strongly attenuated hepatic LPO [40][41][42][43][44][45][46][47][48][49]102,103,[106][107][108][109][110][111][112][113][114][116][117][118][119][120][121][122][123] , usually measured by means of malondialdehyde quantification. Furthermore, melatonin appears to increase the activity and/or expression of hepatic antioxidant enzymes, such as GSH, GPx and SOD, after most types of injury [40][41][42][43][44][45][46][47][48][49][53][54][55][56][57][58][59][60][61][62][63][97][98][99]…”

Section: Antioxidant Effectsmentioning

confidence: 99%

“…Rats, mice [100,101] Doxorubicin 10 mg/kg sc for 7 d hLPO↓, GGT/LDH↓ Rats [102] Endosulfan 10 mg/kg ip for 5 d hLPO↓, AST/ALT/LDH↓, hGSH↑, hMPO↓, hTNF-α/IL-1b↓ Rats [103] Iodine 1 mg/kg per day ip for 14 d Hepatic content of Schiff's bases↓ Rats [104] Kainic acid 4-10 mg/kg ip 1 × Hepatic DNA damage↓ Rats [105] Lead 10-30 mg/kg per day ig for 7-30 d hLPO↓, hGSH/hGPx/hSOD↑, hNEC↓ Rats [106,107] Methanol 10 mg/kg ip 2 × hLPO↓, hGSH/hGPx/hSOD/hCAT↑, hMPO/hNO↓ Rats [108] Methotrexate 10 mg/kg per day ip for 5 d hLPO↓, hGSH↑, hNEC↓ Rats [109] Mercury-(Ⅱ) 10 mg/kg ip 2 × hLPO↓, hGSH↑, hMPO↓ Rats [110] α-Naphthylisothiocyanate 10-100 mg/kg ip/po 1-4 × hLPO↓, AST/ALT/LDH/GGT/ALP/BIL↓, hSOD/hCAT↑, hMPO↓ Rats [111][112][113][114] Nodularin 5-15 mg/kg per day ip for 7 d hGPx/hSOD/hCAT↑ Mice [115] Ochratoxin A 5-20 mg/kg ig/po 1-28 × hLPO↓, GGT/ALP↓, hGSH/hGPx/hSOD/hCAT↑, hNEC↓ Rats [116][117][118][119][120] Paraquat 1-10 mg/kg ip 5-6 × hLPO↓, hGSH↑, LD50 of paraquat↑ Rats [121,122] Phosphine 10 mg/kg ip 1 × hLPO↓, hGSH↑ Rats [123] Safrole 0.1-0.2 mg/kg sc 2 × Hepatic DNA damage↓ Rats [124] Thioacetamide 3 mg/kg ip 3-5 × hLPO↓, AST/ALT/LDH/ammonia↓, hGSH/hCAT↑, hiNOS/hNEC↓ Rats [125][126][127] Zymosan 5-50 mg/kg ip 1-7 × hLPO/hMPO↓ Rats [128,129] Cholestasis Bile-duct ligation 0.5-100 mg/kg per day ip/po for 7-13 d hLPO↓, AST/ALT/GGT/ALP/BIL↓, hGSH/hGPx/hSOD/ hCAT↑, hMPO↓, hNO↓, hNEC↓, iron disturbances↓ Rats [130][131][132][133][134][135]…”

Section: Antioxidant Effectsmentioning

confidence: 99%

“…Furthermore, melatonin appears to increase the activity and/or expression of hepatic antioxidant enzymes, such as GSH, GPx and SOD, after most types of injury [40][41][42][43][44][45][46][47][48][49][53][54][55][56][57][58][59][60][61][62][63][97][98][99]103,[106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][125][126][127][130][131][132][133][134][135][136][137]…”

Section: Antioxidant Effectsmentioning

confidence: 99%

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Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

Mathes¹

2010

WJG

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Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical scavenging capacity. The present report reviews the hepatoprotective potential of the pineal hormone in various models of oxidative stress in vivo, and summarizes the extensive literature showing that melatonin may be a suitable experimental substance to reduce liver damage after sepsis, hemorrhagic shock, ischemia/reperfusion, and in numerous models of toxic liver injury. Melatonin's influence on hepatic antioxidant enzymes and other potentially relevant pathways, such as nitric oxide signaling, hepatic cytokine and heat shock protein expression, are evaluated. Based on recent literature demonstrating the functional relevance of melatonin receptor activation for hepatic organ protection, this article finally suggests that melatonin receptors could mediate the hepatoprotective actions of melatonin therapy.

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“…Bir baş ka ça lış ma da mela to ni nin, an ti ok si dan özel li ği ile, me ta no le bağ lı ka ra ci ğer ha sar lan ma sı nı azalt tı ğı gös te ril miş tir. 23 Me ta nol ze hir len me si olan has ta lar, pH<7.0 ise, ma ru zi yet ten son ra >24 sa at geç miş ise, has ta ko ma du ru mun day sa, be ra be rin de opi ad anal je zikle re ma ru zi yet var sa kö tü prog noz lu ka bul edil meli dir. Öte yan dan, er ken baş vu ran, be ra be rin de eta nol al mış olan, cid di me ta bo lik asi doz ve en sefa lo pa ti si ol ma yan ol gu lar iyi prog noz lu dur.…”

Section: Nephrologyunclassified

Fatal Transdermal Methanol Intoxication: A Case Report and Review of Literature

Gök¹,

Horoz²,

Turgutalp³

et al. 2011

Turkiye Klinikleri J Med Sci

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234etanol, odunun distilasyonu ile elde edilen, kimya endüstrisinde sıklıkla kullanılan, çözücü özelliği taşıyan, renksiz, kokusuz ve acı bir alkol çeşididir. Çeşitli solventler, boya-leke çıkarıcılar, antifirizler, araba camı yıkama sıvıları, kolonya ve ispirto metanol içeren sıvılar-dır. Metanolün kendisi toksik değilse de metabolitleri toksiktir. Alkol dehidrojenaz tarafından formaldehite ve takiben formik aside metabolize edilir. Bu metabolitler metabolik asidoz, körlük, kardiovasküler instabilite, böbrek yetmezliği ve ölüme neden olabilen metanol toksitesinden sorumludur. İntoksikasyon sıklıkla kaza ya da intihar amaçlı oral alımdan sonra olur.1 Ancak oldukça nadiren, inhalasyon, plasental ya da cilt yoluyla dolaCilt Yoluyla Gelişen Fatal Metanol Zehirlenmesi: Olgu Sunumu ve Literatür Derlemesi Ö ÖZ ZE ET T Me ta nol, renk siz, ber rak, ko ku su ve ta dı eta no le ben ze yen, çö zü cü ve te miz lik mad de si birçok kim ya sa lın üre ti min de kul la nı lan ol duk ça tok sik bir mo le kül dür. Cid di me ta nol ze hir len me si, bu mad de le rin in ti har gi ri şi mi ve ya ka za ra çö zü cü le rin oral yol dan alın ma sı ile ge liş mek te dir. Transder mal yol la ge li şen me ta nol ze hir len me si ol duk ça az sa yı da has ta da ra por edil miş tir. Me ta nol zehir len me si nin be lir ti le ri gör me bo zuk lu ğu, be yin öde mi, so lu num yet mez li ği ne ne den olan san tral si nir sis te mi dep res yo nu ve cid di me ta bo lik asi doz dur. Bu ra por da, bi lin cin de bo zul ma, de rin ve hız lı so lu num tab lo suy la acil ser vi se ge ti ri len, cilt yo luy la ge li şen ve fa tal sey re den me ta nol in toksi kas yo nu sap ta nan 57 ya şın da bir ba yan has ta su nul muş tur. Ay nı za man da me ta nol ze hir len me siyle il gi li li te ra tür ge niş bir şekil de göz den ge çi ril miş tir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Beyin ödemi; asidoz; böbrek diyalizi; zehirlenme A AB BS S T TR RA AC CT T Methanol is an extremely toxic molecule. It is clear, colorless, odorless and has a taste similar to ethanol, and utilized to produce a number of cleaning substances and chemicals. Serious methanol intoxication developeds either with accidental ingestion or after suicidal attemps. Transdermal methanol intoxication has been reported only in a few patients. The signs of methanol intoxications are visual impairment, brain edema, central nervous system depression leading to respiratory insufficiency and severe metabolic acidosis. A 57-year-old female patient admitted to emergency room with impaired consciousness, tachypnea and deep breathing was presented in this report. In addition, the literature on methanol intoxication was reviewed.

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Melatonin improves methanol intoxication‐induced oxidative liver injury in rats

Cited by 28 publications

References 46 publications

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

Fatal Transdermal Methanol Intoxication: A Case Report and Review of Literature

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