Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients

Abstract

An elevated oxidative status in the aging organism may be involved in the development of non-insulin dependent diabetes mellitus (NIDDM). Melatonin, a potent antioxidant agent, is essential for glucose homeostasis and regulation. The aim of this study was to determine the influence of melatonin supplementation on the oxidative stress parameters in elderly NIDDM patients. The malondialdehyde (MDA) concentration, Cu-Zn superoxide dismutase (SOD-1) activity in erythrocytes, the level of nitrate/nitrite in plasma and morning melatonin concentration and oxidase activity of ceruloplasmin (Cp) in serum in 15 elderly NIDDM patients at baseline and after the 30 days of melatonin supplementation (5 mg daily) in comparison with levels in 15 healthy elderly volunteers were determined. A significant increase of MDA level and decrease of SOD-1 activity and melatonin concentration were observed in NIDDM patients. Cp oxidase activity and nitrate/nitrite level were similar in both examined groups. Melatonin administration in NIDDM patients resulted in a significant increase in the morning melatonin concentration and SOD-1 activity, and a reduction in the MDA level and Cp oxidase activity. Statistically significant alterations in nitrate/nitrite levels were not observed. These results indicate an improvement of antioxidative defense after melatonin supplementation in the NIDDM individuals and suggest melatonin supplementation as an additional treatment for the control of diabetic complications.

A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women

“…Melatonin consumption (5 mg/ day for 30 days) in type 2 diabetic patients resulted in a significant rise in SOD-1 activity and a reduction in the MDA level [31]. Moreover, 5 mg/day melatonin supplementation for 30 days in primary essential hypertension patients significantly increased SOD-1 and catalase activity and reduced products of lipid peroxidation [34].…”

“…In addition, long-term melatonin consumption (4 mg/ kg/day for 16 weeks) in rats started before the establishment of obesity, attenuated weight gain and prevented the development of obesity induced metabolic alterations [21]. In type 2 diabetic patients, 5 mg/day melatonin consumption for 30 days did not alter body weight and BMI [31]. In another clinical trail, 5 mg/ day melatonin supplementation for 2 months for patients with metabolic syndrome did not change the BMI [32].…”

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

“…Profound studies have shown enhanced oxidative stress in both experimental and human diabetes mellitus [35,36] . Increased levels of liver TBARS has been documented well in diabetic rats [12] .…”

“…Many herbal extracts or derivatives with high antioxidant activity are useful for treatment of diabetes and other metabolic syndrome [5] . Over production of ROS and insufficient antioxidant defense mechanism were well documented in diabetic patients as well as in experimental diabetes mellitus [6,7] .…”

The Protective Effect of Melatonin on the Retinas of Rats with Streptozotocin-Induced Diabetes Mellitus

“…21 Im pro ve ments of an ti o xi da ti ve de fen se we re ob ser ved af ter me la tonin supp le men ta ti on in NIDDM in di vi du als and me la to nin supp le men ta ti on was sug ges ted as an addi ti o nal tre at ment for the con trol of di a be tic comp li ca ti ons. 21 In our study, re sults of me la to nin tre at ment we re si mi lar with tho se stu di es. Me la tonin re du ced oxi da ti ve im pacts of hypergl yce mi a on the re ti na.…”