Melatonin in Psychiatric Disorders – Subtyping Affective Disorder

Wahlund, Björn

doi:10.1159/000014579

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…[ 21 22 23 24 25 26 ] Studies show a seasonal variation in melatonin and serotonin, which may be linked to seasonal pattern seen in some mental disorders. [ 27 ] A spring peak in completed suicide,[ 20 ] hospital admission of bipolar patients[ 21 22 23 24 25 28 ] and mood-worsening in some depressed patients is reported in the literature. [ 23 26 29 ] The effect of the increase in sunlight[ 26 29 30 ] and environmental temperature[ 23 24 26 31 ] is hypothesized to be related to psychiatric changes during spring.…”

Section: Discussionmentioning

confidence: 99%

Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation

et al. 2016

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Childhood disintegrative disorder (CDD) is a rare autistic-like clinical condition with unknown etiology, in that previously acquired age-appropriate language, social and adaptive abilities deteriorate significantly in 2-10-year-old healthy children, although physical and neurological evaluations display no observable abnormality. Our case is a 22-year-old female born of a consanguineous marriage, with the appearance of CDD symptoms in her fifth year of age following normal mental and physical development during her initial four years of life. Without any precipitating factor, she gradually lost her language abilities, social relational skills, affectionate behavior, adaptive capacities, peer play and meaningful interest in her surrounding, friends and family members over a period of 4 years, reaching a plateau in her ninth year of age. The unique special clinical symptom in this case is a seasonal total mutism, which after the beginning of her CDD symptoms is revealing every year covering the spring. As no additional physical or psychological change accompanies her total seasonal speech loss, it cannot be attributed to any mental condition known as having a seasonal pattern. Because in the literature CDD is presented mostly as case reports with lacking of advanced research data, describing any new case is recommended to improve the knowledge about this rare condition, especially if it displays some new unusual signs, not reported till now.

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Section: Discussionmentioning

confidence: 99%

Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation

et al. 2016

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“…139 Subtyping of affective disorders with respect to various markers (psychomotor symptoms, monoamine oxidase, cortisol, and melatonin plasma levels) allowed researchers to identify patients with latent bipolar disorder 140 and thus may be of help for patient profiling. Melatonin has been proposed as a combined marker for the susceptibility to develop affective disorders.…”

Section: Mood Disordersmentioning

confidence: 99%

Melatonin and the Regulation of Sleep and Circadian Rhythms

Guardiola‐Lemaître¹,

Quera-Salva²

2011

Principles and Practice of Sleep Medicine

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“…The action of melatonin as an antiproliferative agent on tumors has heralded it as a treatment for certain types of cancer (Karasek, 1997). It has also been used for treatment of epilepsy (Fautek et al, 1999) and psychiatric disorders (Wahlund, 1999). As a result, the number of people taking melatonin to remedy clinical disorders has increased dramatically over the past decade, yet the full gamut of the acute and chronic effects of melatonin administration is poorly understood.…”

Section: Significance and Future Directionsmentioning

confidence: 99%

Unraveling the enigma: The role of melatonin in seasonal processes in birds

Bentley

2001

Microscopy Res & Technique

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Birds, unlike mammals, do not use the annual profile of pineal melatonin secretion to coordinate their reproductive efforts with a favorable time of year. Melatonin in birds mediates the entrainment of circadian activity rhythms, and thus helps to time hatching of eggs and facilitate migration. However, the role of melatonin as a reliable indicator of day length for seasonal processes has remained equivocal for many years. Recently, the influence of melatonin on two physiological processes involved in aspects of seasonal reproduction has been identified in European starlings: 1) the regulation of seasonal changes in immune function, and 2) neuroplasticity in the song control system. Melatonin can enhance cell-mediated immune function and acts as an inhibitory hormone on the song control system. Melatonin receptor (MelR) density in a forebrain song control nucleus, Area X, is regulated as a function of reproductive state; there is marked downregulation of MelR in Area X during the breeding season in starlings. Seasonal regulation of immune function and neural plasticity within the song control system, and the efficacy of the action of melatonin on these two processes, appears to be modified by the same central, thyroid-dependent mechanism that controls the reproductive state of birds. These data indicate that the interaction of day length and hormones of different classes affects the ability of melatonin to affect seasonal processes in birds. The downstream consequences of MelR regulation within the song control system are discussed with regard to the cellular action of melatonin and its possible interaction with immediate-early genes and transcription factors.

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Melatonin in Psychiatric Disorders – Subtyping Affective Disorder

Cited by 7 publications

References 14 publications

Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation

Childhood disintegrative disorder with seasonal total mutism: A rare clinical presentation

Melatonin and the Regulation of Sleep and Circadian Rhythms

Unraveling the enigma: The role of melatonin in seasonal processes in birds

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