“…Nowadays melatonin, the main product of the pineal gland, has attracted increasing attention because of its protective role in several pathophysiological situations, including different cancer types, where it exerts oncostatic effects (Hill and Blask, 1988; Farriol et al , 2000; Futagami et al , 2001; Cini et al , 2005; Garcia-Santos et al , 2006; Garcia-Navarro et al , 2007; Mauriz et al , 2007; Cabrera et al , 2010; Chiu et al , 2010; Gonzalez et al , 2010; Carbajo-Pescador et al , 2011, 2013). Our group has shown the melatonin oncostatic activity in HepG2 liver tumour cells, highlighting its pro-apoptotic properties through upregulation of cell death-related processes (Martin-Renedo et al , 2008; Carbajo-Pescador et al , 2009, 2011, 2013).…”