Melatonin inhibits neuronal dysfunction‐associated with neuroinflammation by atopic psychological stress in <scp>NC</scp>/Nga atopic‐like mouse models

Park, Gunhyuk; Lee, Jun Young; Oh, Dal‐Seok; Kim, Yong‐ung

doi:10.1111/jpi.12420

Cited by 33 publications

(41 citation statements)

References 85 publications

(179 reference statements)

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“…Hence, chronic GC elevation disturbs neuroendocrine signaling and can induce neuroinflammation, neurotoxicity, and cognitive impairment [ 106 ]. One study assessed the effects of AD-induced stress in a mouse AD model and the results have shown that AD-related PS increased astroglial and microglial activation, neuroinflammatory cytokine expression, and markers of neuronal loss [ 114 ].…”

Section: The Effect Of Stress In Ad On the Hpa Axismentioning

confidence: 99%

“…Melatonin and its metabolites have been to be important for proper physiological skin function and effective protection of a cutaneous homeostasis from adverse environmental stimuli, and its use can attenuate hyperproliferative/inflammatory conditions [ 118 ]. Research has shown that administering melatonin inhibited skin lesions formation, scratching, and elevation of serum IgE levels in the murine AD stressed models [ 114 ]. Furthermore, it caused a significant reduction in CRH responsiveness, and a substantial decrease in neuronal damage [ 114 ].…”

Section: The Effect Of Stress In Ad On the Hpa Axismentioning

confidence: 99%

“…Research has shown that administering melatonin inhibited skin lesions formation, scratching, and elevation of serum IgE levels in the murine AD stressed models [ 114 ]. Furthermore, it caused a significant reduction in CRH responsiveness, and a substantial decrease in neuronal damage [ 114 ]. Research has been conducted on healthy adults to evaluate the effect of psychological relaxation on perturbed skin barrier.…”

Section: The Effect Of Stress In Ad On the Hpa Axismentioning

confidence: 99%

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Association between Stress and the HPA Axis in the Atopic Dermatitis

Lin

Zhong

Santiago

2017

IJMS

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The hypothalamic–pituitary–adrenal (HPA) axis is one of the body’s neuroendocrine networks that responds to psychological stress (PS). In the skin, there exists a peripheral HPA axis similar to the central axis. Glucocorticoids (GCs) are key effector molecules of the HPA axis and are essential for cutaneous homeostasis. Atopic dermatitis (AD) is a condition typically characterized by a chronic relapsing course that often results in PS. HPA dysfunction is present in AD patients by the decreased response of GCs elevation to stress as compared to those unaffected by AD. Nevertheless, in skin, acute PS activates several metabolic responses that are of immediate benefit to the host. During the acute phase of PS, increased endogenous GCs have been shown to provide benefit rather than by aggravating cutaneous inflammatory dermatoses. However, a chronic T helper cell type 2 (Th2) predominant cytokine profile acts as a negative feedback loop to blunt the HPA axis response in AD. In this article, we reviewed the role of CRF, pro-opiomelanocortin (POMC)-derived peptides, GCs of the HPA, and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in AD, with a discussion of the pathogenetic mechanisms of inflammation and skin barrier functions, including antimicrobial defense, and their association with PS.

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Section: The Effect Of Stress In Ad On the Hpa Axismentioning

confidence: 99%

Section: The Effect Of Stress In Ad On the Hpa Axismentioning

confidence: 99%

Section: The Effect Of Stress In Ad On the Hpa Axismentioning

confidence: 99%

See 1 more Smart Citation

Association between Stress and the HPA Axis in the Atopic Dermatitis

Lin

Zhong

Santiago

2017

IJMS

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“…Neuroinflammation and neuroimmune signaling have been reported to be associated with neuronal dysfunction (Hong et al 2016; Park et al 2017). Thus, we tested inflammation-related gene expression in the striatum.…”

Section: Discussionmentioning

confidence: 99%

Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats

Huang

Zheng

et al. 2017

J. Neurovirol.

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Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients receiving combination anti-retroviral therapy (cART). Docosahexaenoic acid (DHA) is a marine compound that modulates inflammatory responses. Using HIV-1Tg rats subjected to binge exposure to ethanol (EtOH), this study examined whether DHA could reduce the detrimental neurological effects of EtOH and HIV proteins. Young adult male HIV-1Tg and F344 control rats received 4 mL/kg/day saline as a control (Saline group), 20 mg/kg/day DHA (DHA group), 4.8 g/kg/day 52% w/v EtOH (EtOH group), or 4.8 g/kg/day 52% w/v EtOH and 20 mg/kg/d DHA (DHA + EtOH group) by gavage for 5 weeks (n = 6 per group). EtOH was administrated on days 5, 6, and 7 of each week. Locomotor activity (LMA) was assessed using open field tests before and 45, 90, 135, and 180 min after each treatment. Repeated binge EtOH exposure gradually decreased LMA measured before daily treatments in HIV-1Tg and F344 rats, an effect that was reversed by DHA only in the HIV-1Tg rats. Decreased LMA of rats after treatment and under the influence of EtOH was less pronounced, and the reversal effect of DHA did not reach statistical significance. The plasma endotoxin level was significantly higher in HIV-1Tg rats than in F344 rats. IL-6 and IL-18 expression in the striatum was significantly higher in the HIV-1Tg EtOH group than in the F344 EtOH group. DHA significantly decreased the high levels of IL-6, IL-18, and NF-κB expression observed in the HIV-1Tg EtOH group. DHA appears to ameliorate inflammation and consequently lessen the reductions in LMA produced by the combination of EtOH and HIV-1 viral proteins.

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“…Western blot was performed as described previously [12]. The dopamine content in the ST of the mouse brain was assessed using a commercially available fluorometric assay kit, following the manufacturer's protocol (Rocky Mountain Diagnostics, Colorado Springs, CO, USA).…”

Section: Western Blot and Determination Of Dopamine Content And Sodmentioning

confidence: 99%

Batryticatus Bombyx Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity by Inhibiting Oxidative Damage

et al. 2019

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Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson’s disease (PD). Altered redox homeostasis in neurons interferes with several biological processes, ultimately leading to neuronal death. Oxidative damage has been identified as one of the principal mechanisms underlying the progression of PD. Several studies highlight the key role of superoxide radicals in inducing neuronal toxicity. Batryticatus Bombyx (BB), the dried larva of Bombyx mori L. infected by Beauveria bassiana (Bals.) Vuill., has been used in traditional medicine for its various pharmacological effects. In the present study, BB showed a beneficial effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity by directly targeting dopaminergic neurons. Treatment with BB improved behavioral impairments, protected dopaminergic neurons, and maintained dopamine levels in PD mouse models. Here, we investigated the protective effects of BB on MPTP-induced PD in mice and explored the underlying mechanisms of action, focusing on oxidative signaling. In MPTP-induced PD, BB promoted recovery from impaired movement, prevented dopamine depletion, and protected against dopaminergic neuronal degradation in the substantia nigra pars compacta (SNpc) or the striatum (ST). Moreover, BB upregulated mediators of antioxidative response such as superoxidase dismutase (SOD), catalase (CAT), glutathione (GSH), Heme oxygenase 1 (HO-1), and NAD(P)H (nicotinamide adenine dinucleotide phosphate) dehydrogenase (NQO1). Thus, treatment with BB reduced the oxidative stress, improved behavioral impairments, and protected against dopamine depletion in MPTP-induced toxicity.

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Melatonin inhibits neuronal dysfunction‐associated with neuroinflammation by atopic psychological stress in NC/Nga atopic‐like mouse models

Cited by 33 publications

References 85 publications

Association between Stress and the HPA Axis in the Atopic Dermatitis

Association between Stress and the HPA Axis in the Atopic Dermatitis

Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats

Batryticatus Bombyx Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity by Inhibiting Oxidative Damage

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