Melatonin inhibits prostaglandin E2- and sodium nitroprusside-induced ion secretion in rat distal colon

Mrnka, Libor; Hock, Miroslav; Rybová, Markéta; Pácha, Jiřı́

doi:10.1016/j.ejphar.2007.11.031

Cited by 20 publications

(12 citation statements)

References 38 publications

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“…The protective role of melatonin on periodontal tissues might be explained to some extent by its antimicrobial action [60], its activation of the immune system [89], and its anti-inflammatory and free radical scavenger effect [90]. In addition, melatonin may modulate periodontal destruction by inhibiting prostaglandin E 2 synthesis and, therefore, inhibit osteoclast differentiation [91], neutralising reactive oxygen species at the level of osteoclast lacuna, with the inhibition of bone resorption and stimulating osteoblast differentiation [30,63]. …”

Section: Discussionmentioning

confidence: 99%

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

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Melatonin is a hormone synthesised and secreted by the pineal gland and other organs. Its secretion, controlled by an endogenous circadian cycle, has been proven to exert immunological, anti-oxidant, and anti-inflammatory effects that can be beneficial in the treatment of certain dental diseases. This article is aimed at carrying out a review of the literature published about the use of melatonin in the dental field and summarising its potential effects. In this review article, an extensive search in different databases of scientific journals was performed with the objective of summarising all of the information published on melatonin use in dental diseases, focussing on periodontal diseases and dental implantology. Melatonin released in a natural way into the saliva, or added as an external treatment, may have important implications for dental disorders, such as periodontal disease, as well as in the osseointegration of dental implants, due to its anti-inflammatory and osseoconductive effects. Melatonin has demonstrated to have beneficial effects on dental pathologies, although further research is needed to understand the exact mechanisms of this molecule.

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Section: Discussionmentioning

confidence: 99%

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

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“…By the way, the effect of sildenafil on enteropooling in the presence of indomethacin seemed much potent than that in control, suggesting that NO might not be the only mediator of this effect. It is known that enteropooling is also stimulated by PGE 2 via 3 0 ,5 0 -cyclic adenosine monophosphate (cAMP) [30]. Because indomethacin decreases PGE 2 production due to COX inhibition and because PGE 2 increases cAMP formation mediated by EP2/EP4 receptors [31], it is understandable that this agent decreased enteropooling.…”

Section: Discussionmentioning

confidence: 99%

Sildenafil, an Inhibitor of Phosphodiesterase Subtype 5, Prevents Indomethacin-Induced Small-Intestinal Ulceration in Rats via a NO/cGMP-Dependent Mechanism

et al. 2008

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We examined the effect of sildenafil, an inhibitor of phosphodiesterase subtype 5, that catalyzes hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP), on indomethacin-induced small-intestinal ulceration in rats and investigated the mechanism of this action, especially in relation to endogenous nitric oxide (NO). Animals without fasting were given indomethacin (10 mg/kg) s.c. and then killed 24 h later. Indomethacin produced hemorrhagic lesions in the small intestine, accompanied by a promotion of enterobacterial invasion and the expression of inducible NO synthase (iNOS) as well as myeloperoxidase (MPO) activity in the mucosa. Sildenafil (3-20 mg/kg), given p.o. 30 min before indomethacin, dose-dependently reduced the severity of these lesions, with concomitant suppression of the increase in MPO activity, iNOS expression and bacterial invasion. These effects were attenuated by the prior administration of the nonselective NOS inhibitor, N (G)-nitro-L-arginine methyl ester, in an L-arginine-reversible manner. Indomethacin also decreased the secretion of mucus and fluid (enteropooling) and enhanced intestinal motility, but these responses were all prevented by the prior administration of sildenafil. Likewise, pretreatment of the animals with NOR-3, a NO donor, also reversed the functional changes caused by indomethacin, followed by suppression of bacterial invasion and iNOS expression, and prevented the development of intestinal lesions. These results suggest that sildenafil prevents indomethacin-induced small-intestinal ulceration in rats, via a NO/cGMP-dependent mechanism, and this effect is functionally associated with an increase in the secretion of mucus/fluid and a decrease of hypermotility, resulting in the suppression of bacterial invasion and iNOS expression following indomethacin treatment.

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“…Furthermore, it has been suggested that melatonin may inhibit bone resorption by modulating proteins and events that regulate the bone resorption process in periodontal disease, e.g. PGE 2 , interleukin (IL)‐1β, IL‐6 and OPG/RANKL system . Melatonin might also act at the level of the osteoclast lacuna where it could inhibit bone resorption by its ability to neutralize ROS .…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde, superoxide dismutase and melatonin levels in gingival crevicular fluid of aggressive and chronic periodontitis patients

Ghallab

Hamdy

Shaker

2016

Australian Dental Journal

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Background: The aim of this study was to investigate malondialdehyde (MDA), superoxide dismutase (SOD) and melatonin levels in the gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) and generalized aggressive periodontitis (GAgP) as biomarkers for oxidative stress. Methods: The study comprised 65 subjects: 15 healthy individuals, 25 CP patients and 25 GAgP patients. Plaque index, gingival index, pocket depth, clinical attachment level measurements and GCF samples were obtained from all subjects. MDA, SOD and melatonin levels were determined utilizing enzyme-linked immunosorbent assay. Results: GCF-MDA levels were significantly higher in the GAgP group compared to the CP and control groups (p < 0.001) and significantly higher in the CP group than the C group (p < 0.001). SOD and melatonin GCF levels were significantly higher in the control than the GAgP and CP groups (p < 0.05), and significantly lower in the GAgP than the CP group (p < 0.05). The CP group demonstrated a significant negative correlation between GCF-MDA and melatonin concentrations. A positive correlation was observed between SOD and CAL in the CP group and PD in the GAgP group. Conclusions: MDA, melatonin and SOD could be considered as biomarkers for oxidative stress in periodontal diseases and might be useful diagnostic aids in distinguishing CP and GAgP patients.

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Melatonin inhibits prostaglandin E2- and sodium nitroprusside-induced ion secretion in rat distal colon

Cited by 20 publications

References 38 publications

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Sildenafil, an Inhibitor of Phosphodiesterase Subtype 5, Prevents Indomethacin-Induced Small-Intestinal Ulceration in Rats via a NO/cGMP-Dependent Mechanism

Malondialdehyde, superoxide dismutase and melatonin levels in gingival crevicular fluid of aggressive and chronic periodontitis patients

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