Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters

Gombert, Marie; Martín-Carbonell, Vanessa; Pin-Arboledas, Gonzalo; Carrasco-Luna, Joaquín; Carrasco-García, Álvaro; Codoñer‐Franch, Pilar

doi:10.3390/nu13103629

Cited by 11 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our previous studies [44] found decreased melatonin levels in overweight children. Another study indicated increased melatonin levels in obese people [45]. The authors attributed this to the fact that melatonin, which is involved in antioxidant and anti-inflammatory protection, may be activated in the context of obesity as a compensatory mechanism.…”

Section: Discussionmentioning

confidence: 96%

Frequency of night eating syndrome and melatonin levels in the urine of adolescents

Sorokman¹,

Khlunovska²

2022

ZMJ

View full text Add to dashboard Cite

Aim. The aim is to study the frequency of night eating syndrome (NES) and its correlation with melatonin levels in the daily urine of adolescents. Materials and methods. Primary screening of 486 adolescents (15–18 years) with complaints of eating disorders, overweight, obesity, which included a survey (test “Depressive Disorders in Adolescents”, Night Eating Questionnaire (NEQ), Dutch Eating Behaviour Questionnaire (DEBQ) and anthropometry (BMI) was conducted. In the second stage, a sample of 56 adolescents (11.5 %) who met the NES criteria of DSM-5 (main group) and 50 adolescents who did not have NES (comparison group) was formed. The urine concentration of 6-sulfatoxymelatonin (6-COMT) was determined by enzyme immunoassay (Buhlmann 6-Sulfatoxymelatonin ELISA Kit, Switzerland). Results. Deficit of body weight had 3 (8.8 %) of adolescent boys, 20 (58.8 %) were overweight, 1 (2.9 %) – obese and only 10 (29.4 %) had the average normative values of body weight; among female adolescents, 1 (4.5 %) – body weight deficit and obesity, 10 (45.5 %) – overweight and average normative indicators. According to the DEBQ, restrictive eating behaviors were identified in 15 (26.8 %) adolescents; in 30 (53.6 %) adolescents – emotional and in 11 (19.6 %) adolescents – external. The mean score of the NEQ was 28.4 ± 2.2 and positively correlated with BMI (r = +0.62, P < 0.05). Participants who exceeded the screening threshold for NES (n = 56, 11.5 %) had increased BMI (P < 0.01), likelihood of overweight/obesity (P = 0.001), consumption of sugary drinks (P < 0.001), daytime sleep less than twice a week (P < 0.01), shorter sleep duration (P < 0.01), high and moderate levels of depression, lower levels of melatonin, which were inversely correlated with the results of the NEQ (r = -0.68, P < 0.05). Conclusions. The prevalence of NES among teenagers was 11.5 %. Among the types of eating behavior, the most common was the emotional type (53.6 %). Adolescents with NES had a significantly higher total depression score (96.7 ± 8.06, P < 0.001) and a lower level of 6-COMT (22.89 ± 3.44, P < 0.001), which was inversely correlated with the degree of NES (r = -0.68, P < 0.05), BMI (r = -0.74; P < 0.01) and depression level (r = -0.65; P < 0.01).

show abstract

Section: Discussionmentioning

confidence: 96%

Frequency of night eating syndrome and melatonin levels in the urine of adolescents

Sorokman¹,

Khlunovska²

2022

ZMJ

View full text Add to dashboard Cite

show abstract

“…Уровень мелатонина у детей с ожирением повышался в течение 1 ч сна, что рассматривалось как компенсаторный механизм. Предполагают, что увеличение образования мелатонина стимулирует сонливость, увеличивает время сна и направлено на противодействие провоспалительным и оксидативным эффектам, вызванным ожирением и недостатком сна [76]. Предполагают, что прием мелатонина, благодаря его противовоспалительному, антиоксидантному и седативному действию, может быть полезен для регуляции метаболических процессов при ожирении.…”

Section: нарушения снаunclassified

The role of exogenous melatonin in the regulation of sleep

Orlova

Nikitina

Balashova

et al. 2022

Medicinskij alfavit

View full text Add to dashboard Cite

Melatonin is a natural hormone produced by the pineal gland and is a derivative of serotonin. One of the key properties of melatonin is its chronobiological ability, realized by multilevel synchronization of biological processes. Physiologically, melatonin secretion increases at night and decreases in the morning. At present, the role of melatonin in the regulation of sleep, circadian rhythms, and adaptation of the body to a rapid change in time zones has been proven. With a decrease in the production of endogenous melatonin in a number of people (with a disorder of daily biorhythms due to long-distance flights, shift work, insomnia), the use of exogenous melatonin improves the quality of sleep.

show abstract

“…The level of melatonin in children with obesity increased during 1 h of sleep, which was up-regulated in the context of obesity as a compensatory mechanism. The organism triggered its production to increase drowsiness, promote behaviors that increased sleep time or counteract the pro-inflammatory and antioxidant effects caused by obesity and lack of sleep [ 157 ]. Therefore, the improvement of sleep disorders by melatonin may be of great significance in the regulation of obesity.…”

Section: Potential Mechanisms Of Melatonin In Obesitymentioning

confidence: 99%

Mechanisms of Melatonin in Obesity: A Review

Guan

Wang

Cao

et al. 2021

IJMS

View full text Add to dashboard Cite

Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is an endogenous hormone found throughout the body that serves various physiological functions. In recent decades, increasing attention has been paid to its unique function in regulating energy metabolism, especially in glucose and lipid metabolism. Accumulating evidence has established the relationship between melatonin and obesity; nevertheless, not all preclinical and clinical evidence indicates the anti-obesity effect of melatonin, which makes it remain to conclude the clinical effect of melatonin in the fight against obesity. In this review, we have summarized the current knowledge of melatonin in regulating obesity-related symptoms, with emphasis on its underlying mechanisms. The role of melatonin in regulating the lipid profile, adipose tissue, oxidative stress, and inflammation, as well as the interactions of melatonin with the circadian rhythm, gut microbiota, sleep disorder, as well as the α7nAChR, the opioidergic system, and exosomes, make melatonin a promising agent to open new avenues in the intervention of obesity.

show abstract

Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters

Cited by 11 publications

References 50 publications

Frequency of night eating syndrome and melatonin levels in the urine of adolescents

Frequency of night eating syndrome and melatonin levels in the urine of adolescents

The role of exogenous melatonin in the regulation of sleep

Mechanisms of Melatonin in Obesity: A Review

Contact Info

Product

Resources

About