Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism

Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Öztekin, Esma; Aydın, Leyla; Sivrikaya, Abdullah

doi:10.1016/j.lfs.2006.01.009

Cited by 37 publications

(26 citation statements)

References 35 publications

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“…A recent publication demonstrated that oxidative stress, caused by excess of morphine, totally inhibited Na + , K + -ATPase activity in adult rat brain (Guzman et al, 2006). As we mentioned earlier, thyroid hormones have a considerable impact on oxidative stress in the rat brain (Mogulkoc et al, 2006), and this chronic treatment to induce hyperthyroidism carried out by us succeeded well to increase T3 serum levels in the animals when compared with controls, as shown in Table 5. We also mentioned that excess of T3 could induce oxidative stress (Santos et al, 2006).…”

Section: Discussionsupporting

confidence: 70%

“…L-T4 group subjects explored the maze faster, although they permanently made mistakes in choosing the right arm of the Y-maze, because they were unable to learn the rule of alternation of the rewarded arm. In vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress, and a similar treatment to induce hyperthyroidism animal model (Mogulkoc et al, 2006) showed that hyperthyroidism increased oxidative damage in the cerebral tissue of rats. Recent findings demonstrated that T3 is associated with oxidative stress through a negative regulation of superoxide dismutase-1 (SOD-1), a key enzyme in the metabolism of oxygen-free radicals (Santos et al, 2006), showing that this effect may be important in T3 induction of oxidative stress in thyroid hormone excess.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Reis-Lunardelli¹,

Castro²,

Bavaresco³

et al. 2007

CNR

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Thyroid hormones (THs), including triiodothyronine (T3) and tetraiodothyronine (T4), are recognized as key metabolic hormones of the body. THs are essential for normal maturation and function of the mammalian central nervous system (CNS) and its deficiency, during a critical period of development, profoundly affects cognitive function. Sodium-potassium adenosine 5'-triphosphatase (Na(+), K(+)-ATPase) is a crucial enzyme responsible for the active transport of sodium and potassium ions in the CNS necessary to maintain the ionic gradient for neuronal excitability. Studies suggest that Na(+), K(+)-ATPase might play a role on memory formation. Moreover, THs were proposed to stimulate Na(+), K(+)-ATPase activity in the heart of some species. In this work we investigated the effect of a chronic administration of L-thyroxine (L-T4) or propylthiouracil (PTU), an antithyroid drug, on some behavioral paradigms: inhibitory avoidance task, open field task, plus maze and Y-maze, and on the activity of Na(+), K(+)-ATPase in the rat parietal cortex and hippocampus. By using treatments which have shown to induce alterations in THs levels similar to those found in hyperthyroid and hypothyroid patients, we aimed to understand the effect of an altered hyperthyroid and hypothyroid state on learning and memory and on the activity of Na(+), K(+)-ATPase. Our results showed that a hyper and hypothyroid state can alter animal behavior and they also might indicate an effect of THs on learning and memory.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Reis-Lunardelli¹,

Castro²,

Bavaresco³

et al. 2007

CNR

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“…This indoleamine has the capacity to resynchronize circadian rhythms [188][189][190] and regulate sleep-wake-cycles [191]. Besides playing an important role as a transmitter of photoperiodic information, melatonin has wellcharacterized antioxidant capacities, either, directly as a free-radical neutralizer or, indirectly by enhancing the activity or the expression of antioxidant enzymes [192,193]. In certain aspects, related to these last activities, there is evidence in the literature that describes potential anti-aging and anticarcinogenic effects for melatonin [194].…”

Section: Melatoninmentioning

confidence: 99%

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Fernández-Santos¹,

García-Marín²,

Utrilla³

et al. 2012

Thyroid Hormone

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“…Further report was also suggested melatonin synthesis by parafollicular cells which secreted locally and might be protecting follicular cells from oxidative damage 48 . However, many researchers have suggested the role of melatonin in the protection of thyroid gland against oxidative damage during both physiological and pathological processes 28,30,49 . Physiological aging is associated with the onset of immunological problems as well as metabolic disturbances.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Receptor (Mt1 and Mt2) Proteins Expression in Thyroid Gland and Level of Thyroxin (T4), Thyrotropin (Tsh) Hormone During Progression of Age in Male Swiss Albino Mice

Laskar¹,

Singh²

2015

J Biol Sci Opin

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Advancement of age is related with a progressive declining in most of the physiological activities. The activity of thyroid gland is also disturbed with increment of age in the organism. Melatonin regulates most of the physiological activities through its membrane bound MT1 and MT2 receptors in mammals. Melatonin receptors were localized on thyroid gland but their abundance on thyroid gland along with progression of age was unknown. In present study we investigated the age related changes in serum T4, TSH level and the abundance of melatonin receptor (MT1 and MT2) proteins in thyroid gland following the immunohistochemical study and western blot analysis. Decreased serum T4 level was noted in aged mice whereas serum TSH level was remained unchanged. Both MT1 and MT2 melatonin receptor proteins abundance was decreased with advancement of age in mice. Our present study may suggest that aging modulates the responsiveness of thyroid gland to melatonin through modulation of melatonin receptor (MT1 and MT2) proteins on thyroid gland. Further, this modulation may be responsible for contribution in the declining of physiological status of the thyroid in the organism.

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Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism

Cited by 37 publications

References 35 publications

Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Melatonin Receptor (Mt1 and Mt2) Proteins Expression in Thyroid Gland and Level of Thyroxin (T4), Thyrotropin (Tsh) Hormone During Progression of Age in Male Swiss Albino Mice

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