Melatonin: Protection against age-related cardiac pathology

Favero, Gaia; Franceschetti, Lorenzo; Buffoli, Barbara; Moghadasian, Mohammed H.; Reíter, Russel J.; Rodella, Luigi Fabrizio

doi:10.1016/j.arr.2016.11.007

Cited by 60 publications

(41 citation statements)

References 252 publications

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“…Our studies and those of other research groups obtained very promising findings regarding a potential role of melatonin in the prevention of obesity and its complications (Agabiti-Rosei et al, 2014;Favero et al, 2015;Szewczyk-Golec et al, 2015). It has been demonstrated that melatonin activates a broad spectrum of molecular pathways, including acting through sirtuin1 (SIRT1), which is an evolutionarily conserved NAD + -dependent deacetylase (Ramis et al, 2015;Favero et al, 2017a). Activation of AMP-activated protein kinase (AMPK) regulates SIRT1 expression.…”

Section: Introductionmentioning

confidence: 78%

RETRACTED: Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury

et al. 2020

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Integrative Physiology, a section of the journal Frontiers in PhysiologyObesity is a worldwide epidemic disease that induces important structural and functional changes to the heart and predisposes a patient to devastating cardiac complications. Sirtuin1 (SIRT1) has been found to have roles in regulating cardiac function, but whether it can help in cardioprotection is not clear. The aim of the present study was to determine whether melatonin, by modulating SIRT1 and in turn mitochondria signaling, may alleviate obesity-induced cardiac injuries. We investigated 10 lean control mice and 10 leptin-deficient obese mice (ob/ob) orally supplemented with melatonin for 8 weeks, as well as equal numbers of age-matched lean and ob/ob mice that did not receive melatonin. Hearts were evaluated using multiple parameters, including biometric values, morphology, SIRT1 activity and expression of markers of mitochondria biogenesis, oxidative stress, and inflammation. We observed that ob/ob mice experienced significant heart hypertrophy, infiltration by inflammatory cells, reduced SIRT1 activity, altered mitochondrial signaling and oxidative balance, and overexpression of inflammatory markers. Notably, melatonin supplementation in ob/ob mice reverted these obesogenic heart alterations. Melatonin prevented heart remodeling caused by obesity through SIRT1 activation, which, together with mitochondrial pathways, reduced oxidative stress and inflammation.Homogenized heart tissues were adequately processed for the quantitative measurement of natriuretic peptides type-B (BNP) protein level using a specific ELISA Kit (Novus Biologicals, Abingdon, United Kingdom), according to the manufacturer's Frontiers in Physiology | www.frontiersin.org

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Section: Introductionmentioning

confidence: 78%

RETRACTED: Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury

et al. 2020

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“…Reduced urinary 6-SM excretion has been linked to coronary artery disease (CAD); the severity of CAD was negatively associated with urinary 6-SM excretion [40]. Melatonin is known to influence the cardiovascular system via both its antioxidant and anti-inflammatory activities [41]. In rats with renovascular hypertension, the cardiac function improved after treatment with melatonin, implying a possible therapeutic role of melatonin [42].…”

Section: Discussionmentioning

confidence: 99%

Urinary Excretion of 6-Sulfatoxymelatonin, the Main Metabolite of Melatonin, and Mortality in Stable Outpatient Renal Transplant Recipients

Veen

Minovíc

Faassen

et al. 2020

JCM

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Melatonin is a multifaceted hormone which rises upon the onset of darkness. Pineal synthesis of melatonin is known to be disturbed in patients with end-stage renal disease, but it is not known if its production is restored to normal after successful renal transplantation. We hypothesized that urinary excretion of 6-sulfatoxymelatonin, the major metabolite of melatonin, is lower in renal transplant recipients (RTRs) compared to healthy controls and that this is associated with excess mortality. Urinary 6-sulfatoxymelatonin was measured via LC-MS/MS in 701 stable outpatient RTRs and 285 healthy controls. Median urinary 6-sulfatoxymelatonin in RTR was 13.2 nmol/24 h, which was 47% lower than in healthy controls. Urinary 6-sufatoxymelatonin appeared undetectable in the majority of 36 RTRs with diabetic nephropathy as primary renal disease. Therefore, this subgroup was excluded from further analyses. Of the remaining 665 RTRs, during 5.4 years of follow-up, 110 RTRs died, of whom 38 died due to a cardiovascular cause. In Cox-regression analyses, urinary 6-sulfatoxymelatonin was significantly associated with all-cause mortality (0.60 (0.44–0.81), p = 0.001) and cardiovascular mortality (0.49 (0.29–0.84), p = 0.009), independent of conventional risk factors and kidney function parameters. Based on these results, evaluation and management of melatonin metabolism could be considered for improvement of long-term outcomes in RTRs.

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“…Additionally, melatonin upregulates the expression and activity of several antioxidant enzymes, preserving the optimal function of mitochondria, and contributing to the attenuation of oxidative stress [3]. Melatonin may be associated with the prevention of chronic diseases related to aging and oxidative stress, including type-2 diabetes, obesity, and cardiovascular diseases [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats

Rebollo‐Hernanz

Aguilera

Herrera

et al. 2020

Foods

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Melatonin is a multifunctional antioxidant neurohormone found in plant foods such as lentil sprouts. We aim to evaluate the effect of lentil sprout intake on the plasmatic levels of melatonin and metabolically related compounds (plasmatic serotonin and urinary 6-sulfatoxymelatonin), total phenolic compounds, and plasmatic antioxidant status, and compare it with synthetic melatonin. The germination of lentils increases the content of melatonin. However, the phenolic content diminished due to the loss of phenolic acids and flavan-3-ols. The flavonol content remained unaltered, being the main phenolic family in lentil sprouts, primarily composed of kaempferol glycosides. Sprague Dawley rats were used to investigate the pharmacokinetic profile of melatonin after oral administration of a lentil sprout extract and to evaluate plasma and urine melatonin and related biomarkers and antioxidant capacity. Melatonin showed maximum concentration (45.4 pg/mL) 90 min after lentil sprout administration. The plasmatic melatonin levels increased after lentil sprout intake (70%, p < 0.05) with respect to the control, 1.2-fold more than after synthetic melatonin ingestion. These increments correlated with urinary 6-sulfatoxymelatonin content (p < 0.05), a key biomarker of plasmatic melatonin. Nonetheless, the phenolic compound content did not exhibit any significant variation. Plasmatic antioxidant status increased in the antioxidant capacity upon both lentil sprout and synthetic melatonin administration. For the first time, we investigated the bioavailability of melatonin from lentil sprouts and its role in plasmatic antioxidant status. We concluded that their intake could increase melatonin plasmatic concentration and attenuate plasmatic oxidative stress.

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Melatonin: Protection against age-related cardiac pathology

Cited by 60 publications

References 252 publications

RETRACTED: Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury

RETRACTED: Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury

Urinary Excretion of 6-Sulfatoxymelatonin, the Main Metabolite of Melatonin, and Mortality in Stable Outpatient Renal Transplant Recipients

Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats

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