Melatonin protects against ischemia-reperfusion injury and inhibits apoptosis in isolated working rat heart

Dobšák, Petr; Siègelovà, Jarmila; Eicher, Jean‐Christophe; Jančík, Jiří; Svačinová, Hana; Vašků, Julie Bienertová; Kuchtíčková, Šárka; Horký, Marcel; Wolf, Jean-Éric

doi:10.1016/s0928-4680(02)00080-9

Cited by 62 publications

(52 citation statements)

References 45 publications

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“…(17,42). However, there is increasing evidence that cardiac cell death and arrhythmias, beside necrosis, could also occur through apoptosis (23,38,40,72) via different signaling mechanisms. Thus it is reasonable to assume that both necrosis and apoptosis are responsible for cell death and the development of arrhythmias, and a reduction in the activity of their putative pathways, at least in part, could significantly contribute to the recovery of postischemic cardiac function and the reduction of the incidence of arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective mechanisms ofPrunus cerasus(sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts

Bak¹,

Lekli²,

Juhász³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts. Am J Physiol Heart Circ Physiol 291: H1329 -H1336, 2006. First published April 14, 2006 doi:10.1152/ajpheart.01243.2005The effects of kernel extract obtained from sour cherry (Prunus cerasus) seed on the postischemic cardiac recovery were studied in isolated working rat hearts. Rats were treated with various daily doses of the extract for 14 days, and hearts were then isolated and subjected to 30 min of global ischemia followed by 120 min of reperfusion. The incidence of ventricular fibrillation (VF) and tachycardia (VT) fell from their control values of 92% and 100% to 50% (not significant) and 58% (not significant), 17% (P Ͻ 0.05), and 25% (P Ͻ 0.05) with the doses of 10 mg/kg and 30 mg/kg of the extract, respectively. Lower concentrations of the extract (1 and 5 mg/kg) failed to significantly reduce the incidence of VF and VT during reperfusion. Sour cherry seed kernel extract (10 and 30 mg/kg) significantly improved the postischemic recovery of cardiac function (coronary flow, aortic flow, and left ventricular developed pressure) during reperfusion. We have also demonstrated that the extract-induced protection in cardiac function significantly reflected in a reduction of infarct size. Immunohistochemistry indicates that a reduction in caspase-3 activity and apoptotic cells by the extract, beside other potential action mechanisms of proanthocyanidin, trans-resveratrol, and flavonoid components of the extract, could be responsible for the cardioprotection in ischemic-reperfused myocardium.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective mechanisms ofPrunus cerasus(sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts

Bak¹,

Lekli²,

Juhász³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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“…Also, in a study by Dobsak et al [31], melatonin exhibited a significant dose-dependent protective effect against the damage inflicted by the peroxyl radical. In a review article authored by Sahna et al [106], the authors claimed that total antioxidant capacity (TAC) of human serum is directly related to melatonin levels, as shown earlier by Benot et al [115].…”

Section: Important Issues Related To the Use Of Melatoninmentioning

confidence: 92%

“…A large amount of data published by a variety of investigations has demonstrated that melatonin can effectively reduce myocardial IR injury (Table 1). In a study using a working heart model, Dobsak et al [31] document that the treatment with melatonin caused a significant improvement of hemodynamic parameters and a reduction of postischemic arrhythmias during reperfusion; the ability of melatonin to correct cardiac arrhythmias was also noted by Diez et al [32]. A review by Dominguez-Rodriguez et al [33] suggests that melatonin plays a key role in coronary heart disease; this is consistent with observations that melatonin reduces infarct size after experimental heart attack [34].…”

Section: Introductionmentioning

confidence: 99%

A review of melatonin as a suitable antioxidant against myocardial ischemia–reperfusion injury and clinical heart diseases

Yang

Sun

et al. 2014

Journal of Pineal Research

161

141

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Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia-reperfusion (IR) injury. In particular, the myocardial protection of melatonin is substantial. We initially focus on the cardioprotective effects of melatonin in myocardial IR. These studies showed how melatonin preserves the microstructure of the cardiomyocyte and reduces myocardial IR injury. Thereafter, downstream signaling pathways of melatonin were summarized including Janus kinase 2/signal transducers and activators of transcription 3, nitric oxide-synthase, and nuclear factor erythroid 2 related factor 2. Herein, we propose the clinical applications of melatonin in several ischemic heart diseases. Collectively, the information summarized in this review (based on in vitro, animal, and human studies) should serve as a comprehensive reference for the action of melatonin in cardioprotection and hopefully will contribute to the design of future experimental research.

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“…Dobsak et al [24] aimed to reveal the effects of melatonin in the model of isolated and perfused working rat heart, to evaluate the antioxidant capacity of melatonin and to analyse the extent of apoptosis inhibition by melatonin. The rats were divided into four groups.…”

Section: Medicine Science 2014;3(4):1766-80mentioning

confidence: 99%

The Antioxidant Effect of Melatonin on Myocardial Ischemia Reperfusion Injury in Experimental Studies

Parlakpınar¹,

Örüm²

2014

Med-Science

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Melatonin protects against ischemia-reperfusion injury and inhibits apoptosis in isolated working rat heart

Cited by 62 publications

References 45 publications

Cardioprotective mechanisms ofPrunus cerasus(sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts

Cardioprotective mechanisms ofPrunus cerasus(sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts

A review of melatonin as a suitable antioxidant against myocardial ischemia–reperfusion injury and clinical heart diseases

The Antioxidant Effect of Melatonin on Myocardial Ischemia Reperfusion Injury in Experimental Studies

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