Melatonin reduces oxidative damage induced by aluminium in rat kidney

Mahieu, Stella; Contini, María del Carmen; González, Marcela; Millen, Néstor

doi:10.1016/j.toxlet.2009.06.852

Cited by 55 publications

(51 citation statements)

References 43 publications

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“…These effects could be responsible for the increase in aldosterone levels in Al-treated rats, which is reversed by the presence of Mel. In male rats, the increase of the concentration of aldosterone was accompanied with an increase of the Na + -K + -ATPase activity in the kidney [49]. This was not observed in any of the female groups studied.…”

Section: Discussionmentioning

confidence: 65%

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Contini

Millen

González

et al. 2011

Biol Trace Elem Res

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This study is designed to determine the simultaneous effect of aluminium (Al) and melatonin (Mel) treatment in intact and ovariectomized (Ovx) female rats on oxidative stress and their inter-organ relationship in the kidney and liver. Al-treated rats received an intra-peritoneal injection of solution of aluminium lactate (0.575 mg Al/100 g of body weight, three times a week), during 12 weeks. Mel groups received intra-peritoneal injections of melatonin at a dose of 10 mg/kg/day, 5 days/week, during 12 weeks. The results of this study showed that Al treatment in female rats modifies homeostasis of glutathione and the antioxidant capacity of the rat liver and kidney. The alteration of glutathione homeostasis and oxidative status was not associated with an increased lipid peroxidation in both organs with the exception of the increase observed in the liver of Ovx rats. Al also induced modifications in the activity of some enzymes related to the glutathione cycle: GSH-Px in the liver and kidney and glutathione reductase only in the kidney. Al exposure decreased CAT activity in both the kidney and liver of intact and Ovx groups. The administration of Mel in the intact and castrated females treated with Al seems to reduce oxidative changes in the liver and kidney of intact and Ovx rats.

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Section: Discussionmentioning

confidence: 65%

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Contini

Millen

González

et al. 2011

Biol Trace Elem Res

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“…In vivo and in vitro, melatonin has been known as a radical scavenger with the ability to remove ROS and reactive nitrogen species. 17 Regarding the protective effect of melatonin on renal alterations various studies have been carried out and it has been found to protect tissues against oxidative damage generated by a variety of toxic agents. 18 Nitric oxide (NO) is a free radical gaseous molecule with a biological half-life of a few seconds.…”

Section: Introductionmentioning

confidence: 99%

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

et al. 2012

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Objectives: The aim of this study was to investigate the preventive effects of melatonin and vitamin C as antioxidants on renal injury in chronic alcohol consumption. Materials and methods: A total of 24 adult male Wistar rats weighing 200-250 g were used in the study. Rats were divided into four equal groups. Group I (control): rats were not fed on alcohol; Group II: rats were fed on alcohol; Group III: rats were fed on alcohol and 40 mg/kg vitamin C; and Group IV: rats were fed on alcohol and 4 mg/kg melatonin. Results: Light microscopic examination revealed atrophic renal corpuscles, dilatation and congestion of the peritubular vessels, and renal corpuscles with obscure Bowman's space and a few foamy-appearing tubules due to alcohol consumption were observed. Expression of endothelial nitric oxide synthase (eNOS) was localized to glomerulus, distal, and collector tubules. eNOS staining decreased in alcohol treatment group and melatonin and vitamin C encore increased expression pattern of eNOS. Alcohol consumption increased malondialdehyde (MDA) level and superoxide dismutase (SOD) and catalase (CAT) activities significantly in the alcohol consumption groups compared with that in the control group, while in melatonin give group just MDA level was decreased statistically significant and SOD and CAT activities were also decreased numerically compared with the alcohol consumption groups. Conclusions: These results indicated that chronic alcohol consumption caused renal damage by increased lipid peroxidation and melatonin and vitamin C administration produced in some degree protection against alcohol-induced damage.

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“…Furthermore, the water intake of aluminium treated rats was not different from controls as demonstrated by Mahieu et al (2009). On contrary, Benlahcen et al (2009), Kahloula et al (2009) and Kowalczyk et al (2004) found a decrease in feed and water intake due to lead acetate and aluminium chloride administration when compared to control group.…”

Section: Discussionmentioning

confidence: 81%

“…Moreover, Bhadauria (2012) and Turkez et al (2010) indicated that ALT was significantly increased after aluminum exposure. In addition, Mahieu et al (2009) found that the level of GGT in serum of aluminium treated rats was reduced than controls.…”

Section: Discussionmentioning

confidence: 94%

Impact of Some Heavy Metals Toxicity on Behaviour, Biochemical and Histopathological Alterations in Adult Rats

Goma¹,

Tohamy²

2016

Adv. Anim. Vet. Sci.

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A nimal welfare is an issue not only for veterinary science and animal psychology but also for biochemical, agriculture, zoology and companion animal fields because animal welfare is a socially constructed idea and it is not a permanently fixed idea (Watanabe, 2007). On the other hand, animals are very good indicator of environmental pollution as they inhabit the same space as human and exposed to action of the same pollutants, for that reason it is appropriate and advantageous to evaluate the negative impact of the polluted environment by heavy metals on human health by parallel evaluation of their load on animals (Kozak et al., 2002).Lead is a one of the major heavy metals known to be toxic to mammals. It had many sources as metallic lead present in storage batteries, paints and rubbish dumps in areas near lead industrial establishments and also from the industrial applications especially the addition of vast quantities of research Article Abstract | Animal welfare is a matter of societal concern and debate, its improvement should consider those aspects actually affecting animal's health, through determining their impact on some welfare indicators, so, this study was conducted to investigate the effect of heavy metals toxicity on behavioural, biochemical and histopathological changes in adult rats. Twenty-five Sprague-Dawley adult rats were allotted into five groups, each of 5, two groups (GA & GB) treated with lead acetate (low 1g/l & high 2g/l) and another two (GC & GD) treated with anhydrous aluminium chloride (low 2 g/l & high 3.5 g/l) in drinking water daily for 5 weeks, while, GE (control) received drinking water without any treatment. The findings obtained indicated that feeding time, drinking, cage and total exploration frequencies increased in GB than other groups, although, lying time decreased. However, the movement activities increased in GA than others. On the other hand, glucose level decreased significantly in GB than GD and control. Furthermore, triglycerides and total lipid levels were significantly decreased in all treated groups than control. It was also revealed that the serum ALT increased significantly in GB than other groups while creatinine decreased significantly in both groups (GA & GB) treated with lead acetate than other groups with most decrement in high dose group of lead acetate. However, the urea level decreased and uric acid increased significantly in all treated groups than control. Microscopically, degenerated and necrotic hepatocytes, tubular and glomerulus's necrosis were observed in all toxicated rats beside eosinophilic intranuclear inclusions in lining epithelium of some renal tubules of lead toxicated rats. Therefore, it can be concluded that different toxic levels of lead acetate and aluminum chloride can affect animal's welfare by behavioural, biochemical and histopathological alterations in a dose dependent manner. Keywords

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Melatonin reduces oxidative damage induced by aluminium in rat kidney

Cited by 55 publications

References 43 publications

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Melatonin Prevents Oxidative Stress in Ovariectomized Rats Treated with Aluminium

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

Impact of Some Heavy Metals Toxicity on Behaviour, Biochemical and Histopathological Alterations in Adult Rats

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