Melatonin reduces X-ray radiation-induced lung injury in mice by modulating oxidative stress and cytokine expression

Jang, Seong Soon; Kim, Hyeong Geug; Lee, Jin Seok; Han, Jong Min; Park, Hye Jung; Huh, Gil Ja; Son, Chang Gue

doi:10.3109/09553002.2013.734943

Cited by 55 publications

(37 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Jang et al (2013)have shown that the administration of melatonin before lung irradiation ameliorates the upregulation of TNF-α, TGF-β, and IL-6. Also, they showed an increase in SOD and catalase activity and GSH levels, and a reduction of oxidative damage in lung tissue compared to irradiation only (Jang et al 2013). TGF-β has a suppressive effect on SOD and catalase gene expression.…”

Section: Effect Of Melatonin On Cytokines Production Following Irradimentioning

confidence: 99%

“…Thus, melatonin, through these pathways, may reduce both acute and chronic consequences caused by inflammation following radiotherapy (Bondy et al 2004). Jang et al (2013)have shown that the administration of melatonin before lung irradiation ameliorates the upregulation of TNF-α, TGF-β, and IL-6. Also, they showed an increase in SOD and catalase activity and GSH levels, and a reduction of oxidative damage in lung tissue compared to irradiation only (Jang et al 2013).…”

Section: Effect Of Melatonin On Cytokines Production Following Irradimentioning

confidence: 99%

See 1 more Smart Citation

The melatonin immunomodulatory actions in radiotherapy

et al. 2017

View full text Add to dashboard Cite

Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune system responses play a pivotal role in many of the early and late side effects of radiation. Moreover, immune cells have a significant role in tumor response to radiotherapy, such as angiogenesis and tumor growth. Melatonin as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs. These effects are mediated through various modulatory effects of melatonin in different levels of tissue reaction to ionizing radiation. The effects on the DNA repair system, antioxidant enzymes, immune cells, cytokines secretion, transcription factors, and protein kinases are most important. Moreover, anti-cancer properties of melatonin may increase the therapeutic ratio of radiotherapy. Clinical applications of this agent for the management of malignancies such as breast cancer have shown promising results. It seems anti-proliferative, anti-angiogenesis, and stimulation or suppression of some immune cell responses are the main anti-tumor effects of melatonin that may help to improve response of the tumor to radiotherapy. In this review, the effects of melatonin on the modulation of immune responses in both normal and tumor tissues will be discussed.

show abstract

Section: Effect Of Melatonin On Cytokines Production Following Irradimentioning

confidence: 99%

Section: Effect Of Melatonin On Cytokines Production Following Irradimentioning

confidence: 99%

The melatonin immunomodulatory actions in radiotherapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In addition to neutralizing ROS species, Mel also acts via the stimulation of various anti-oxidative systems and stabilizes cell membranes (19). As such, Mel modulates the gene expression levels of numerous protective enzymes to reduce apoptosis and lipid peroxidation (20,21). Mel has previously been demonstrated to improve the survival rates of mice when administered prior to irradiation exposure (22).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase-3

Li¹,

Zhang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Neuronal cell apoptosis is associated with various factors that induce neurological damage, including radiation exposure. When administered prior to exposure to radiation, a protective agent may prevent cellular and molecular injury. The present study aimed to investigate whether melatonin exerts a neuroprotective effect by inhibiting the caspase cell death pathway. Male Sprague-Dawley rats were administered melatonin (100 mg/kg body weight) 30 min prior to radiation exposure in red light during the evening. In order to elucidate whether melatonin has a neuroprotective role, immunohistochemistry, terminal deoxynucleotidyl transferase dUTP nick-end labeling, Nissl staining, reverse transcription-quantitative polymerase chain reaction, reactive oxygen species analysis and western blotting were performed. At 24 h post-melatonin treatment, caspase-3 mRNA and protein expression levels were significantly decreased. These results demonstrated that melatonin may protect hippocampal neurons via the inhibition of caspase-3 when exposed to irradiation. Therefore, caspase-3 inhibition serves a neuroprotective and antioxidant role in the interventional treatment of melatonin. The results of the present study suggested that melatonin may have a potential therapeutic effect against irradiation; however, further studies are required in order to elucidate the underlying antioxidant mechanisms.

show abstract

“…Entre os modelos animais atualmente utilizados, tem-se observado uma resposta adequada à indução de dislipidemia e inflamação, porém elevada resistência à indução de estresse oxidativo. Essa limitação metodológica tem sido superada através de intervenções mais agressivas e muitas vezes sem correspondência com o modelo humano, tais como exposição à radiação, aplicação de tetracloreto de carbono (CCl 4 ) e manipulação genética como os animais knockouts para as enzimas atioxidantes (Nomura e Yamaoka, 1999;Cooper et al, 2002;Kunitomo et al, 2009;Zhang et al, 2009;Chew et al, 2010;Sakata et al, 2012;Jang et al, 2013;Laher et al, 2013).…”

Section: Introductionunclassified

“…As formas de indução do estresse oxidativo são mais complexas, incluindo exposição à radiação, administração de CCl 4 , aplicação de estreptozotocina para indução de diabetes, exposição excessiva à poluentes ou fumaça de cigarro, exercício físico extenuante, ou uso de animais transgênicos ou "knockout" para enzimas antioxidantes (Nomura e Yamaoka, 1999;Cooper et al, 2002;Kunitomo et al, 2009;Zhang et al, 2009;Chew et al, 2010;Sakata et al, 2012;Jang et al, 2013;Laher et al, 2013 (Sentman et al, 2006).…”

Section: Introductionunclassified

Avaliação do consumo de lipídios oxidados na indução do estresse oxidativo associado à aterosclerose em modelo animal

Nogueira¹

View full text Add to dashboard Cite

Melatonin reduces X-ray radiation-induced lung injury in mice by modulating oxidative stress and cytokine expression

Abstract: The present results suggest that melatonin reduces radiation-induced lung injury via a significant reduction of oxidative stress and of the production of cytokines, such as TGF-β1 and TNF-α, the production of which increased following lung irradiation.

Cited by 55 publications

References 37 publications

The melatonin immunomodulatory actions in radiotherapy

The melatonin immunomodulatory actions in radiotherapy

Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase-3

Avaliação do consumo de lipídios oxidados na indução do estresse oxidativo associado à aterosclerose em modelo animal

Contact Info

Product

Resources

About