Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish

Montalbano, Giuseppe; Mania, Manuela; Abbate, Francesco; Navarra, Michele; Guerrera, Maria Cristina; Laurà, Rosaria; Vega, J.A.; Levanti, Maria; Germanà, Antonino

doi:10.1007/s12020-018-1653-x

Cited by 42 publications

(32 citation statements)

References 60 publications

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“…Such increase in body weight and BMI appears more pronounced in female than male, probably in links with oogenesis and egg storage. In zebrafish, several DIO and/or HFD models have been proposed and lead to similar metabolic impairments as observed in our study, reinforcing the data obtained in this work [13][14][15][16][17]42,43 . The higher body weight and BMI observed in overfed fish should reflect the development of adipose tissue, as overfeeding protocols using artemia have been previously shown to promote subcutaneous and/or visceral adipocyte expansion in zebrafish 14,15,17 .…”

Section: Discussionsupporting

confidence: 91%

Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract

Ghaddar

Veeren

Rondeau

et al. 2020

Sci Rep

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overweight and obesity are worldwide health concerns leading to many physiological disorders. Recent data highlighted their deleterious effects on brain homeostasis and plasticity, but the mechanisms underlying such disruptions are still not well understood. in this study, we developed and characterized a fast and reliable diet-induced overweight (DIO) model in zebrafish, for (1) studying the effects of overfeeding on brain homeostasis and for (2) testing different preventive and/or therapeutic strategies. By overfeeding zebrafish for 4 weeks, we report the disruption of many metabolic parameters reproducing human overweight features including increased body weight, body mass index, fasting blood glucose levels and liver steatosis. Furthermore, DIO fish displayed blood-brain barrier leakage, cerebral oxidative stress, neuroinflammation and decreased neurogenesis. Finally, we investigated the preventive beneficial effects of A. borbonica, an endogenous plant from Reunion island. overnight treatment with A. borbonica aqueous extract during the 4 weeks of overfeeding limited some detrimental central effects of DIO. In conclusion, we established a relevant DIO model in zebrafish demonstrating that overfeeding impairs peripheral and central homeostasis. This work also highlights the preventive protective effects of A. borbonica aqueous extracts in Dio, and opens a way to easily screen drugs aiming at limiting overweight and associated neurological disorders. Obesity and overweight are defined as excessive body weight characterized by body fat accumulation and could be easily estimated by calculating the body mass index (BMI) 1. Both obesity and overweight are among the main health concerns worldwide. Their prevalence is increasing annually in developing and developed countries and has nearly tripled since 1980s according to the World Health Organization (2019). Overweight and obesity are due to an imbalance between energy intake, storage, and expenditure including interactions with hereditary and environmental factors 2-4. They result in numerous metabolic disorders such as dyslipidemia, non-alcoholic fatty liver, hyperglycemia, insulin resistance, and are characterized by chronic inflammation and oxidative stress 5-7. These pathologies lead to many physiological disorders such as cardiovascular complications as well as the development of type 2 diabetes and contribute to increased morbidities 7,8. In addition to impair peripheral metabolism and homeostasis, overweight and obesity could have a negative impact on central nervous system (CNS) homeostasis, leading to cognitive impairments and dementia 9. Such cognitive defects have been reported in many animal models such as in high fat diet (HFD)-treated rodents displaying hippocampal-dependent cognitive impairments 10,11. Among factors contributing to these cognitive dysfunctions, inflammatory and oxidative stress appear as key players leading to blood-brain barrier (BBB) leakage through decreased expression of tight junction proteins in the hippocampus 12. Other studi...

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Section: Discussionsupporting

confidence: 91%

Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract

Ghaddar

Veeren

Rondeau

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…50 Moreover, studies conducted on zebrafish showed that melatonin enhances orexinergic signals. 60 CCK has also been shown to increase the orexin level of the posterior rat brain by more than 35% after intraperitoneal injection of orexin. 57 Animal studies have also shown that corticotrophin-releasing factor innervates orexinergic neurons in the lateral hypothalamic nucleus.…”

Section: Hormones and Nutrients Regulating Orexin Activitiesmentioning

confidence: 96%

“…Experimental studies have shown that glucose is capable of stimulating orexin release from pancreatic beta cells . Moreover, studies conducted on zebrafish showed that melatonin enhances orexinergic signals . CCK has also been shown to increase the orexin level of the posterior rat brain by more than 35% after intraperitoneal injection of orexin .…”

Section: Hormones and Nutrients Regulating Orexin Activitiesmentioning

confidence: 99%

Hypocretin/orexin modulates body weight and the metabolism of glucose and insulin

Adeghate

Lotfy

D’Souza

et al. 2020

Diabetes Metabolism Res

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Summary The hypocretin/orexin (Hcrt/orexin) unit affects the functions of the nervous, cardiovascular, gastrointestinal, and reproductive systems. Hcrt/orexin ligands and receptors have been localized to different parts of the central and peripheral nervous systems, cerebrospinal fluid and blood, exocrine (pancreas, salivary, lacrimal) as well as endocrine (pancreatic islets, pituitary, adrenal) glands. Several factors including stress, glucagon‐like peptide‐1 agonists, glutamate, nicotine, glucose, and hypoglycaemia stimulate the expression of Hcrt/orexin system, but it is inhibited by ageing, bone morphogenetic protein, hypoxia/hypercapnia, melanocortin receptor accessory protein 2, and glucagon. Literature reports show that Hcrt/orexin can significantly increase insulin secretion from normal and diabetic rat pancreata. Hcrt/orexin decreases blood glucose concentration and reduces insulin resistance partly via increased tissue expression of glucose transporter type 4. It reduces obesity by increasing browning of fat cells and energy expenditure. Taken together, Hcrt/orexin modulates obesity and the metabolism of glucose and insulin. The Hcrt/orexin system may thus be a target in the development of new therapies for the treatment of diabetes mellitus.

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“…Using St. John's wort (Hypericum perforatum L. cv. Anthos) seedlings as the plant material, Murch et al [4] exogenously supplied 14 C labeled tryptophan and found the presence of radioactive tryptamine, 5-hydroxytryptophan, serotonin, indoleacetic acid and melatonin via adopted isotope tracer approach. Among them, tryptophan and 5-hydroxytryptophan are the synthetic precursors of melatonin in animals.…”

Section: The Biosynthetic Pathway Of Melatonin In Plantsmentioning

confidence: 99%

“…Currently, melatonin is regarded as an over-the-counter medicine and health care product to relieve sub-health and improve sleep [11]. Some studies indicated that regular consumption of melatonin-rich foods can significantly improve human health [12][13][14]. In view of the health benefits of melatonin, more and more nutritionists begin to pay attention to the amount of melatonin in food, hoping that people can get more natural melatonin from daily food.…”

Section: The Biosynthetic Pathway Of Melatonin In Plantsmentioning

confidence: 99%

Review of Melatonin in Horticultural Crops

Yan¹,

Shi²,

Gong³

2020

Melatonin - The Hormone of Darkness and Its Therapeutic Potential and Perspectives

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Melatonin is an indoleamine, abundant in animals and plants, which has the functions of regulating circadian rhythm, improving immunity and anti-aging in animals, and is a good health care product beneficial to human health. Recent studies have shown that melatonin has physiological functions including regulating plant growth, promoting seed germination, controlling root development and delaying leaf senescence. The antioxidant properties of melatonin give it the ability to strengthen plants' resistance to stress. The comprehensive researches in recent years, involving five aspects of "the biosynthetic pathway of melatonin in plants, the melatonin in horticultural crops and its influencing factors, the roles of melatonin in the growth and development of horticultural crops, in the response to stress of horticultural crops, the signal transduction network of melatonin in regulating plant growth and the development and stress resistance," are reviewed in the present paper. The application of melatonin in horticulture production is also discussed, which can provide a theoretical reference for the application of melatonin in horticultural production. DOI: http://dx.doi.org/10.5772/intechopen.90935 excess ROS to reduce the oxidation of cells. However, a recent study in rice (Oryza sativa L.) has shown that the key melatonin synthesis gene COMT is located in plant chloroplasts and has demonstrated that melatonin synthesis is increased through the 5-MT pathway [8]. CAND2/PMTR1, a hypothetic plant melatonin receptor, recently has been identified in Arabidopsis thaliana [9]. It is located in the plasma membrane with a receptor-like topology and interacts with the G-protein subunit (GPA1), while expression in different tissues is induced by melatonin. The binding of plant melatonin receptors triggers Gγb and Gα activation of NADPH oxidasedependent H 2 O 2 production (RBOH), increasing Ca 2+ inflow, promoting K + outflow, and ultimately leading to stomatal closure [10]. The cloning of these melatoninmetabolizing genes and the discovery of the receptors can lay a certain foundation for the study of melatonin-related functions in the future. Review of Melatonin in Horticultural Crops Concentrations of melatonin in horticultural crops and its influential factors

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Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish

Abstract: It seems that adequate melatonin treatment exerts anti-obesity protective effects, also in a diet-induced obesity zebrafish model, that might be the result of the restoration of many factors: the final endpoint reached is weight loss and stabilization of weight gain.

Cited by 42 publications

References 60 publications

Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract

Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract

Hypocretin/orexin modulates body weight and the metabolism of glucose and insulin

Review of Melatonin in Horticultural Crops

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