MELD and other predictors of survival after liver transplantation

Brandão, Ajácio; Fuchs, Sandra Costa; Gleisner, Ana; Marroni, Cláudio Augusto; Zanotelli, Maria Lúcia; Cantisani, Guido Pio Gracco

doi:10.1111/j.1399-0012.2008.00943.x

Cited by 47 publications

(45 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on easily measurable laboratory data 2,5,6 , the MELD score has been considered more transparent and objective 2,5,7 for the ordination of liver disease on the waiting list for TH. Nevertheless, although it has been validated as a predictor of mortality in the list, the role of this scoring system for predicting survival after HT remains controversial 3,6,8 , which could suggest the need to readjust the graft allocation criteria for a model that also took into consideration the results of TH 8 . The objective of this study was to evaluate the accuracy of preoperative MELD score to predict survival after TH and also analyze factors predictive of mediumterm survival (24 months).…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

“…However, the shortage of liver grafts persists as the main limiting factor for its development 1 . In order to reduce the number of deaths on the waiting list 2,3 and eliminate possible confounding factors related to the chronological system, a new policy for allocation of liver grafts, based on the MELD (Model for End-Stage Liver Disease) system has been adopted in Brazil since July 4, 2006 4 . Based on easily measurable laboratory data 2,5,6 , the MELD score has been considered more transparent and objective 2,5,7 for the ordination of liver disease on the waiting list for TH.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

See 1 more Smart Citation

Emprego do escore MELD para a predição da sobrevivência pós-transplante hepático

Batista¹,

Sabat²,

Melo³

et al. 2012

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

. We used analysis of area under ROC (receiver operating characteristic) as a summary measure of the performance of the MELD score and assessed predictors of medium-term survival using univariate and multivariate analysis. Results Results ResultsResults Results: The cumulative survival of three, six, 12 and 24 months of the 208 patients studied was 85.1%, 79.3%, 74.5% and 71.1%, respectively. The preoperative MELD score showed a low discriminatory power for predicting survival after TH. By univariate analysis, we identified intraoperative transfusion of red blood cells (p <0.001) and platelets (p = 0.004) and type of venous hepatocaval anastomosis (p = 0.008) as significantly related to medium-term survival of the patients studied. However, by multivariate analysis only red blood cell transfusion was a significant independent predictor of outcome. Conclusion Conclusion Conclusion Conclusion Conclusion: The MELD score showed low overall accuracy for predicting post-transplant survival of patients studied, among which only intraoperative transfusion of red blood cells was identified as an independent predictor of survival in the medium term after TH.

show abstract

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Emprego do escore MELD para a predição da sobrevivência pós-transplante hepático

Batista¹,

Sabat²,

Melo³

et al. 2012

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

show abstract

“…There are few studies correlating pretransplant MELD score with survival after living donor liver transplantation (6,20,33,35) . Hayashi et al (20) found no association between MELD score and patient survival in living donor liver transplantation recipients.…”

Section: Discussionmentioning

confidence: 99%

“…The present study evaluated 78 consecutive patients submitted to living donor liver transplantation divided into two groups according to graft survival. Statistical analysis demonstrated the importance of MELD score and GRBW ratio for the prediction of post-transplant outcomes (5,6,27,31,36) . An increase in survival and improved outcomes of living donor liver transplantation were obtained in different series conducted in Europe and the United States when rigorous selection criteria were applied to donors and recipients (9,26,28) .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive factors of early graft loss in living donor liver transplantation

Alves

Fonseca

Mattos

et al. 2012

Arq. Gastroenterol.

View full text Add to dashboard Cite

CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into >18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. RESULTS: MELD score <18 (P<0.001) and serum sodium level > 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores > 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. CONCLUSIONS: MELD scores >18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation.

show abstract

Liver Transplantation

2017

Pathology of Liver Diseases

View full text Add to dashboard Cite

MELD and other predictors of survival after liver transplantation

Abstract: Severe pre-transplant liver disease, age > or = 65, non-white skin donor, and hepatocellular carcinoma are associated with poor outcome.

Cited by 47 publications

References 37 publications

Emprego do escore MELD para a predição da sobrevivência pós-transplante hepático

Emprego do escore MELD para a predição da sobrevivência pós-transplante hepático

Predictive factors of early graft loss in living donor liver transplantation

Liver Transplantation

Contact Info

Product

Resources

About