Melioidosis in India and Bangladesh: A review of case reports

Tipre, Meghan; Kingsley, Paul Vijay; Smith, Tom E. C.; Leader, Mark; Sathiakumar, Nalini

doi:10.4103/1995-7645.233179

Cited by 14 publications

(19 citation statements)

References 4 publications

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“…pseudomallei is responsible for a melioidosis fatality rate of around 10% and 40%, respectively [ 2 , 5 , 6 ]. There is also emerging evidence that melioidosis is endemic in Central and South America [ 7 , 8 ], southern regions of China [ 9 , 10 ] and India [ 11 , 12 ]. The global distribution of B .…”

Section: Introductionmentioning

confidence: 99%

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

Simpanya

Settles

et al. 2019

PLoS Negl Trop Dis

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Burkholderia pseudomallei causes melioidosis, a common source of pneumonia and sepsis in Southeast Asia and Northern Australia that results in high mortality rates. A caprine melioidosis model of aerosol infection that leads to a systemic infection has the potential to characterize the humoral immune response. This could help identify immunogenic proteins for new diagnostics and vaccine candidates. Outbred goats may more accurately mimic human infection, in contrast to the inbred mouse models used to date. B. pseudomallei infection was delivered as an intratracheal aerosol. Antigenic protein profiling was generated from the infecting strain MSHR511. Humoral immune responses were analyzed by ELISA and western blot, and the antigenic proteins were identified by mass spectrometry. Throughout the course of the infection the assay results demonstrated a much greater humoral response with IgG antibodies, in both breadth and quantity, compared to IgM antibodies. Pre-infection sera showed multiple immunogenic proteins already reactive for IgG (7–20) and IgM (0–12) in most of the goats despite no previous exposure to B. pseudomallei. After infection, the number of IgG reactive proteins showed a marked increase as the disease progressed. Early stage infection (day 7) showed immune reaction to chaperone proteins (GroEL, EF-Tu, and DnaK). These three proteins were detected in all serum samples after infection, with GroEL immunogenically dominant. Seven common reactive antigens were selected for further analysis using ELISA. The heat shock protein GroEL1 elicited the strongest goat antibody immune response compared to the other six antigens. Most of the six antigens showed the peak IgM reactivity at day 14, whereas the IgG reactivity increased further as the disease progressed. An overall MSHR511 proteomic comparison between the goat model and human sera showed that many immune reactive proteins are common between humans and goats with melioidosis.

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Section: Introductionmentioning

confidence: 99%

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

Simpanya

Settles

et al. 2019

PLoS Negl Trop Dis

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“…46 articles with a total of 70 patients were selected for full text review. 15 articles, with a total of 29 patients were excluded due to insufficient clinical information (n = 12) [ 1 , 3 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ] or no report of microbiological diagnosis (n = 3) [ 21 , 22 , 23 ]. A total of 31 articles [ 5 , 10 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ] with 41 patients met the inclusion criteria of this systematic review.…”

Section: Resultsmentioning

confidence: 99%

Melioidosis and the Heart: A Systematic Review

Velusamy

Muhi

2020

TropicalMed

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Melioidosis is caused by Gram-negative bacterium Burkholderia pseudomallei. Clinical presentation can vary from pneumonia, sepsis and multi-focal abscess formation. The aim of this study was to systemically review the cardiac manifestations of melioidosis in the literature and describe their epidemiology, microbiological diagnosis and outcomes. A systematic review of the peer-reviewed literature was carried out in PubMed and Google Scholar for human melioidosis cases with cardiac involvement. Quantitative data for cases of melioidosis were obtained, including age, sex, microbiological diagnosis, treatment, and outcome. 980 articles were screened, of which 31 articles were eligible. The most common cardiac site of infection was pericarditis, followed by endocarditis and myocarditis. Over 95% of cardiac involvement occurred in males, and mortality was the lowest in pericarditis and highest in myocarditis. Valvular vegetations were all small, left-sided, and did not require surgery. Antibiotic treatment included a bactericidal induction therapy with ceftazidime or a carbapenem ± TMP-SMX, followed by eradication therapy with TMP–SMX in most patients as previously established. In conclusion, melioidosis varies in clinical presentation and is also known as a great imitator. Although cardiac involvement is rare, this is the first systematic review to summarise all cases reported in the literature to date.

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“…All of the parotid gland abscesses occurred among females, two of whom were pediatric cases aged 3 and 12 years. [14] It is possible that the proportion of parotid abscess in India may be due to exposure to Burkholderia pseudomallei through ingestion of unchlorinated drinking water. A majority of rural population in India have limited access to chlorinated drinking water which may increase their risk of contracting melioidosis.…”

Section: Discussionmentioning

confidence: 99%

Melioidosis Presenting as Parotid Abscess in an Adult - A Case Report

Chandrasekaran¹,

Ravichandran²,

Paulraj³

et al. 2020

IJMBS

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Burkholderia pseudomallei, a facultative intracellular Gram-negative bacterium casuses melioidosis, a tropical disease which is more commonly reported these days. Melioidosis can present as visceral abscess, pneumonia, localized ulcers, musculoskeletal and neurological infections, even as full blown sepsis. Melioidosis presenting as parotid abscess is commonly reported among pediatric population, however in adults it is a rare entity with only very few cases being reported. There are very limited studies that have described melioidosis with abscess in unusual sites apart from liver and splenic abscess. Here we present a case of a diabetic male with left sided parotid abscess and on microbiological evaluation found to have melioidosis which was successfully treated with combined surgical and medical treatment.

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Melioidosis in India and Bangladesh: A review of case reports

Cited by 14 publications

References 4 publications

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

Melioidosis and the Heart: A Systematic Review

Melioidosis Presenting as Parotid Abscess in an Adult - A Case Report

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