Melioidosis Pneumonitis

Spotnitz, Murray

doi:10.1001/jama.1967.03130230076013

Cited by 46 publications

(6 citation statements)

References 6 publications

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“…Cases acquired outside the indigenous area are rarely reported (9)(10)(11)(12)(13)(14). This organism may remain indolent for long periods, requiring considerable diagnostic vigilance (15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

“…The pulmonary form most commonly encountered (20, 23) presents as a lower respiratory tract infection or apparent tuberculosis (16). Frequency of presenting signs and symptoms have been well studied by others; fever, productive cough, and weight loss occurred in more than 90%, pleural pain in 50%, hemoptysis in about 30%; dyspnea and hepatosplenomegaly are uncommon.…”

Section: Discussionmentioning

confidence: 99%

“…The broad-spectrum antimicrobial resistance of this organism prompted review of American and French Indochina melioidosis experience, which showed repetitively that antimicrobial resistance followed inadequate duration of therapy (16,34). Multiple short courses of antimicrobials to treat our patient's earlier osteomyelitis favored resistance.…”

Section: The Septic Form Reaches a Zenith In 48 To 96 H; Mortality Ismentioning

confidence: 99%

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Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials¹

Cf¹,

Rc²,

Jp³

1983

Am Rev Respir Dis

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We describe a recent case of melioidosis presenting classically in a young Vietnam veteran. The case demonstrates extensive antibiotic resistance in this isolate and failure of ceftriaxone, despite its in vitro efficacy. Other multiple antimicrobial regimens also failed. Melioidosis remains a concern in patients who have previously lived in endemic areas. A high level of diagnostic suspicion is required, especially in patients with a febrile illness or tuberculosis-like presentations. Early detection of Pseudomonas pseudomallei and rational treatment of adequate duration are critical in successful management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: The Septic Form Reaches a Zenith In 48 To 96 H; Mortality Ismentioning

confidence: 99%

See 1 more Smart Citation

Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials¹

Cf¹,

Rc²,

Jp³

1983

Am Rev Respir Dis

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“…Those patients were diagnosed because diseased or wounded soldiers were referred to modern hospitals of either Republic of South Vietnam or United States, where microbiological laboratories were available for diagnosis of melioidosis as well as for other infectious diseases. Within the year of 1966, a series of 9 cases of pulmonary melioidosis in U.S. soldiers was described [ 13 ]. Another nine cases of melioidosis in U.S. soldiers, including four fatal cases, were diagnosed in Vietnam in Long Binh (now Dong Nai province in the South) [ 14 ].…”

Section: Review Of Melioidosis In Vietnammentioning

confidence: 99%

Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting

Trung

Nguyen²,

Nguyen

et al. 2018

TropicalMed

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The first cases of human melioidosis were described in Vietnam in the 1920s, almost a century ago. It was in Vietnam in the thirties that the saprophytic nature of B. pseudomallei was first recognized. Although a significant number of French and U.S. soldiers acquired the disease during the Vietnam wars, indigenous cases in the Vietnamese population were only sporadically reported over many decades. After reunification in 1975, only two retrospective studies reported relatively small numbers of indigenous cases from single tertiary care hospitals located in the biggest cities in the South and the North, respectively. Studies from provincial hospitals throughout the country were missing until the Research Network on Melioidosis and Burkholderia pseudomallei (RENOMAB) project started in 2014. From then on seminars, workshops, and national scientific conferences on melioidosis have been conducted to raise awareness among physicians and clinical laboratory staff. This led to the recognition of a significant number of cases in at least 36 hospitals in 26 provinces and cities throughout Vietnam. Although a widespread distribution of melioidosis has now been documented, there are still challenges to understand the true epidemiology of the disease. Establishment of national guidelines for diagnosis, management, and reporting of the disease together with more investigations on animal melioidosis, genomic diversity of B. pseudomallei and its environmental distribution are required.

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“…THE treatment of melioidosis is far from satisfactory. Chloramphenicol is considered the drug of choice by some authors'3 while others favor tetracycline.4 5 Mortality in chronic and subacute melioidosis has been considerably reduced, but patients with acute fulminant melioidosis, particularly those with diffuse pul¬ monary involvement, usually pro¬ gress rapidly to death. Mortality in this group of patients may still approach 90%.…”

mentioning

confidence: 99%

Acute Septicemic Melioidosis

Zimmerman¹

1970

JAMA

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Melioidosis Pneumonitis

Cited by 46 publications

References 6 publications

Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials¹

Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials¹

Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting

Acute Septicemic Melioidosis

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Melioidosis Pneumonitis

Cited by 46 publications

References 6 publications

Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials1

Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials1

Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting

Acute Septicemic Melioidosis

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Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials¹

Melioidosis: Recrudescence with a Strain Resistant to Multiple Antimicrobials¹