Melkersson-Rosenthal syndrome and crohn's disease

Worsaae, Nils; Christensen, K. C.; Bondesen, S; Jarnum, S.

doi:10.1016/0007-117x(80)90070-0

Cited by 30 publications

(21 citation statements)

References 10 publications

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“…Worsaae et al (1980, 1982) found that two of their 33 OFG cases (6%) had elevated IgE levels; our figure was 15 of 33 cases tested (45%). This may be consistent with recent work showing the presence in OFG of subepithelial dendritic B cells that express IgE (Patel et al , 2010).…”

Section: Discussionmentioning

confidence: 46%

“…Wiesenfeld et al (1985) carried out a wide range of haematological tests on their cases but only reported results for those cases who had a firm diagnosis of Crohn’s disease and who could not, therefore, be regarded as typical of OFG cases. Worsaae et al (1980, 1982) had haemoglobin, iron studies and ESR results for all of their 33 cases and stated ‘no patterns indicating inflammatory activities were observed…’Sanderson et al (2005) reported slight anaemia in one of 35 cases; one case had low ferritin. Three cases had low B 12 , and three cases low folate.…”

Section: Discussionmentioning

confidence: 99%

“…When we view our haematological and immunological findings in the light of previous reports, the major differences are the high incidence of elevated alkaline phosphatase levels (18%), low lymphocyte counts and elevated coeliac antibodies. The only previous reports of alkaline phosphatase were of normal levels (Worsaae et al , 1980, 1982). There are no previous reports of lowered lymphocyte counts or elevated coeliac antibodies.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of patients with orofacial granulomatosis

et al. 2011

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Characteristics of patients with orofacial granulomatosis

et al. 2011

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“…The association of GC and CD is rarely described in the literature ( 4–10). Whether GC is a manifestation of CD or a distinct pathologic entity is still controversial ( 11–14). We describe a 3‐year‐old boy who was admitted to our institute with GC.…”

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confidence: 99%

Granulomatous Cheilitis and Crohn's Disease in a 3‐Year‐Old Boy

Dummer

Lurz

Jeschke

et al. 1999

Pediatric Dermatology

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Granulomatous cheilitis and Crohn's disease are disorders of unknown etiology. There are case reports describing their coincidence and pointing out the necessity of ruling out systemic disorders once the diagnosis of granulomatous cheilitis is made. However, such reports are few and the causal association of both diseases is controversial in the literature. We report the youngest patient so far, a 3-year-old boy, who had granulomatous cheilitis and Crohn's disease simultaneously. This coincidence so early in life strongly suggests that both represent manifestations of the same disease.

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“…As in any granulomatous lesions, differential list is very exhaustive. Crohn’s and sarcoidosis needs to be ruled out first, as these diseases may co express or may develop during the course of MRS [2,3]. Histologically granulomas may not been seen in all cases, but that does not rule out the diagnosis of MRS.…”

Section: Introductionmentioning

confidence: 99%

Melkerrson-Rosenthal Syndrome, a rare case report of chronic eyelid swelling

2013

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Melkerrson-Rosenthal syndrome is a rare disorder of unknown etiology. The classical triad of recurrent facial paralysis, swelling of the face, lips and deep furrowed tongue (Lingua Plicata) is seen in very few cases, majority of the patients often present with one or two symptoms only, which often leads to misdiagnosis and mismanagement. Clinically these symptoms vary from days to years, which further delay the definitive diagnosis and symptoms may eventually become permanent. The cause of this entity is not very well understood, but thought to be attributable to multiple entities including genetic and Infectitious. As this entity has been associated with numerous other clinical entities, diagnosis often remains an exclusion process. Methods: A middle age male with a chronic history of heavy eyelids with skin indurations predominately around left eye was presented to ophthalmology clinic. Physical examination revealed a deep furrowed tongue. The skin biopsy from left eyelid revealed a non-specific granulomatous lesion. The clinical correlation of facial swelling and deep plicated tongue prompted the differential of MRS Results: Histologically a non-specific granulomatous lesion was seen in dermis. As a rule, other causes of granulomatous diseases were ruled out especially Crohn’s disease and sarcoidosis. Polarization failed to reveal any foreign body. Conclusions: The finding of granulomatous lesion and clinical picture led to the definite diagnosis of Melkerrson-Rosenthal syndrome. Association with rosacea was other findings. Clinically his sign and symptoms are under control and no occurrence of symptoms has been noted so far.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1647494495993706

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Melkersson-Rosenthal syndrome and crohn's disease

Cited by 30 publications

References 10 publications

Characteristics of patients with orofacial granulomatosis

Characteristics of patients with orofacial granulomatosis

Granulomatous Cheilitis and Crohn's Disease in a 3‐Year‐Old Boy

Melkerrson-Rosenthal Syndrome, a rare case report of chronic eyelid swelling

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