Members of a family of drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs

Olfactory regulation of mosquito–host interactions

“…Several members of the OBP/PBP family of olfactory proteins have been cloned and characterized from several insects including D. melanogaster (Pikielny et al, 1994), Apis mellifera (Briand et al, 2001) and true bugs (Dickens et al, 1998). More recently several subfamilies of putative OBPs have been identified in An.…”

Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor

“…A small deficit in odor-sensing was noted although the mechanism is unclear. Interestingly, a potential role for RKIP in olfaction has been suggested for its Drosophila homologs [48]. Several Drosophila PEBP isoforms have been identified from an antennal cDNA library, and four of these genes are expressed in hairs of the third antennal segment, which serves as an olfactory organ.…”

From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site

“…At the molecular level, the capacity of the 21 23 kDa protein family to bind hydrophobic ligands is confirmed; indeed, the bovine brain protein was shown to bind phosphatidylethanolamine [8], the rat brain protein was purified using its affinity for morphine [16], the rat tPBP was shown to bind phosphatidylethanolamine [21] and the putative OBP in Drosophila may be able to bind odorant molecules [26]. Furthermore, when comparing the amino acid sequences of the 21 23 kDa protein family members, the central region constituted by residues 60 126 appeared to be particularly well conserved (see Fig.…”

“…The sequence homology observed between TFS1 and the brain 21-23 kDa protein suggested that the latter could be implicated in the control of cerebral cell growth and maturation [27]. The putative odorant-binding protein (OBP) was detected in drosophila hairs [26]. A polymerase chain reaction-based method was used to clone a cDNA encoding this protein and in situ hybridization led to the localization of OBP in scattered sensilla on the posterior surface of the fly antenna.…”

“…A polymerase chain reaction-based method was used to clone a cDNA encoding this protein and in situ hybridization led to the localization of OBP in scattered sensilla on the posterior surface of the fly antenna. The OBP has a putative signal sequence at its amino terminus suggesting that it is secreted into the lumen of olfactory hairs [26].…”