Membrane-Based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-Coated Crystals/Particles

Chen, Dengyue; Sirkar, Kamalesh K.; Jin, Chi; Singh, Dhananjay Kumar; Pfeffer, Robert

doi:10.2174/1381612822666161025145229

Cited by 29 publications

(12 citation statements)

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“…Macro ATR-FTIR spectroscopic imaging has been used to monitor affinity chromatography purification of monoclonal antibodies [3], a particularly useful investigatory method which looks at the binding capacity of resin. This is important due to the high financial cost of replacing protein A resin [124]. Macro ATR-FTIR spectroscopic imaging has been successfully applied to cleaning procedures of a fouling layer on membranes such as polypropylene (PP), and polytetrafluoroethylene (PTFE) [125], the small penetration depth of ATR is well suited to this application due to the thin nature of membranes.…”

Section: Atr-ftir Spectroscopic Imaging Applied To Biopharmaceuticalsmentioning

confidence: 99%

ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

Tiernan

Byrne

Kazarian

2020

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

150

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Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is a label-free, non-destructive technique that can be applied to a vast range of biological applications, from imaging cancer tissues and live cells, to determining protein content and protein secondary structure composition. This review summarises the recent advances in applications of ATR-FTIR spectroscopy to biopharmaceuticals, the application of this technique to biosimilars, and the current uses of FTIR spectroscopy in biopharmaceutical production. We discuss the use of ATR-FTIR spectroscopic imaging to investigate biopharmaceuticals, and finally, give an outlook on the possible future developments and applications of ATR-FTIR spectroscopy and spectroscopic imaging to this field. Throughout the review comparisons will be made between FTIR spectroscopy and alternative analytical techniques, and areas will be identified where FTIR spectroscopy could perhaps offer a better alternative in future studies. This review focuses on the most recent advances in the field of using ATR-FTIR spectroscopy and spectroscopic imaging to characterise and evaluate biopharmaceuticals, both in industrial and academic research based environments.

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Section: Atr-ftir Spectroscopic Imaging Applied To Biopharmaceuticalsmentioning

confidence: 99%

ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

Tiernan

Byrne

Kazarian

2020

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

150

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“…This reduces significantly the carbon footprint and economical cost, and permits further recycling of the membranes, in comparison to cross-linked materials which cannot be reprocessed. The use of PET as a recyclable high performance material for membranes has the potential to contribute to the sustainability of purification and separation processes, particularly in the pharmaceutical and food industries …”

Section: Introductionmentioning

confidence: 99%

Recycled Poly(ethylene terephthalate) for High Temperature Solvent Resistant Membranes

Pulido

Habboub

Aristizábal

et al. 2019

ACS Appl. Polym. Mater.

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Porous membranes of recycled poly(ethylene terephthalate) (PET) were prepared by nonsolvent-induced phase separation (NIPS) and evaluated for the first time for the filtration in high temperature solvents and other harsh environments. The PET was recycled from commercial water bottles. The morphology, pore size, and pore density were optimized by varying the composition of the polymer concentration in the casting solution, the solvent, and the nonsolvent bath in conditions of controlled humidity and temperature. Poly(ethylene glycol) (PEG) of 0.2 and 1 kg mol–1 was used as an additive and pore inducing agent. The filtration performance of the membranes was tested under different solvents and temperatures. The obtained PET membranes were successfully applied for ultrafiltration with a MWCO of 40 kg mol–1 in dimethylformamide (DMF) at temperatures up to 100 °C. PET membranes were found to be resistant to a wide variety of solvents as well as in chlorine and acid medium. They could be used as porous support for thin-film composite membranes and for different applications requiring high chemical and heat resistance.

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“…The medical and pharmaceutical sector is also a broad consumer of different membrane techniques, including controlled release systems, blood fractionation or artificial kidney [9,10]. Moreover, the membrane technology is widely used in water and wastewaters treatment [11].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Polyamide-Supported Chitosan Nanocomposite Membranes for Hydrophilic Pervaporation

et al. 2018

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An experimental protocol of preparation of homogeneous and nanocomposite chitosan (Ch) based membranes supported on polyamide-6 (PA6) films was developed and described in detail. Montmorillonite (MMT) and Cloisite 30B (C30B) nanoclays were used as nanofillers to improve mechanical properties of chitosan films. The surface, mechanical, and transport properties of PA6 supported Ch, Ch/MMT and Ch/C30B membranes were studied and compared with a pristine, non-supported chitosan membrane. Implementation of advanced analytical techniques e.g., SEM reveal the clays nanoparticles are well dispersed in the chitosan matrix. According to AFM images, composite chitosan/nanoclay membranes possess higher roughness compared with unfilled ones. On the other hand, an incorporation of clay particles insignificantly changed the mechanical and thermal properties of the membranes. It was also found that all membranes are hydrophilic and water is preferentially removed from EtOH/H2O and iPrOH/H2O mixtures by pervaporation. Supporting of chitosan and chitosan/nanoclay thin films onto PA6 porous substrate enhanced permeate flux and pervaporation separation index, in comparison to the pristine Ch membrane. Concerning separation factor (β), the highest value equal to 4500 has been found for a chitosan composite membrane containing Cloisite 30B contacting 85/15 wt % iPrOH/H2O mixture. The mentioned membrane was characterized by the normalized flux of 0.5 μm kg m−2 h−1. Based on the established data, it was possible to conclude that chitosan membranes are meaningful material in dehydration of azeotropic mixtures. Nevertheless, to boost up the membrane efficiency, the further modification process is required.

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Membrane-Based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-Coated Crystals/Particles

Cited by 29 publications

References 0 publications

ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

Recycled Poly(ethylene terephthalate) for High Temperature Solvent Resistant Membranes

Development and Characterization of Polyamide-Supported Chitosan Nanocomposite Membranes for Hydrophilic Pervaporation

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