Membrane cholesterol plays an important role in enteropathogen adhesion and the activation of innate immunity via flagellin–TLR5 signaling

Zhu, Guoqiang; Duan, Qiangde; Li, Yinchau; Yang, Yang; Hardwidge, Philip R.; Zhu, Guoqiang

doi:10.1007/s00203-015-1115-2

Cited by 7 publications

(7 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A genome-wide association study (GWAS) complemented with high-throughput human in vitro susceptibility testing (Hi-HOST) showed the mutations in the VAC14 gene and it has been linked to an increase in plasma membrane cholesterol which in turn facilitates the Salmonella Typhi docked firmly to the host cell [16]. There is plenty of literature showing that plasma membrane cholesterol content is an essential factor for E. coli, S. pneumoniae and toxins of Acinetobacter species to enter the host cells [79][80][81]. Therefore, the enhanced expression of VAC14 could be responsible for its protection against S. Typhi and suggests that rs8060947 could be a biomarker for enteric fever disease risk prediction.…”

Section: Vac14: Acts As Core Subunit Of Lipid Kinase In Signalling Thmentioning

confidence: 99%

Human Genetic Variation Influences Enteric Fever Progression

Yee

Tan

Hee

et al. 2021

Cells

View full text Add to dashboard Cite

In the 21st century, enteric fever is still causing a significant number of mortalities, especially in high-risk regions of the world. Genetic studies involving the genome and transcriptome have revealed a broad set of candidate genetic polymorphisms associated with susceptibility to and the severity of enteric fever. This review attempted to explain and discuss the past and the most recent findings on human genetic variants affecting the progression of Salmonella typhoidal species infection, particularly toll-like receptor (TLR) 4, TLR5, interleukin (IL-) 4, natural resistance-associated macrophage protein 1 (NRAMP1), VAC14, PARK2/PACRG, cystic fibrosis transmembrane conductance regulator (CFTR), major-histocompatibility-complex (MHC) class II and class III. These polymorphisms on disease susceptibility or progression in patients could be related to multiple mechanisms in eliminating both intracellular and extracellular Salmonella typhoidal species. Here, we also highlighted the limitations in the studies reported, which led to inconclusive results in association studies. Nevertheless, the knowledge obtained through this review may shed some light on the development of risk prediction tools, novel therapies as well as strategies towards developing a personalised typhoid vaccine.

show abstract

Section: Vac14: Acts As Core Subunit Of Lipid Kinase In Signalling Thmentioning

confidence: 99%

Human Genetic Variation Influences Enteric Fever Progression

Yee

Tan

Hee

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…Mammalian species have an innate and an acquired immune system. The innate immune system is the first line of defense against pathogens ( Zhou et al , 2015 ). The toll-like receptor (TLR) family is a group of pattern recognition receptors (PRRs) that play important roles in sensing pathogen-associated molecular patterns (PAMPs) in innate immunity ( Wack and Gallorini, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood

Gan

Qin

et al. 2018

Genet. Mol. Biol.

View full text Add to dashboard Cite

MYD88 plays an important role in the immune response against infections. To analyze MYD88 gene expression during different stages of pig development, we used real-time PCR. MYD88 was seen expressed in all tissues examined. MYD88 expression in spleen, lungs, and thymus reached its highest value from 7 to 14 days of age and decreased thereafter. Expression in lymph nodes was high until 28 days of age and then it declined after weaning, with stable low levels in adult pigs. MYD88 expression was high before 35 days of age in the small intestine (duodenum, jejunum, and ileum), where it reached its highest value from 7 to 14 days of age. MYD88 expression in the small intestine declined post-weaning and remained relatively low during adulthood. The results of this study suggest that weaning stress and development of the immune system might be positively correlated with MYD88 expression regulation. Moreover, this study provided evidence that the high expression of MYD88 may diminish weaning stress and increase disease resistance in Meishan pigs.

show abstract

“…TLR5 is a special TLR that is thought to be related to the prevention of microbiological diseases, especially intestinal lesions caused by pathogenic adhesion of Escherichia coli. When TLR5 is lacking, E. coli flagellin cannot transmit signals through TLR5, which limits the body's immune response [24]. TLR5-deficient mice are prone to overeating and to develop metabolic syndrome compared with wild-type mice [25].…”

Section: Intestinal Microbiota Regulates Immune Responses In the Bodymentioning

confidence: 99%

Intestinal microbiota: a new force in cancer immunotherapy

Dai

Zhang

et al. 2020

Cell Commun Signal

View full text Add to dashboard Cite

Cancer displays high levels of heterogeneity and mutation potential, and curing cancer remains a challenge that clinicians and researchers are eager to overcome. In recent years, the emergence of cancer immunotherapy has brought hope to many patients with cancer. Cancer immunotherapy reactivates the immune function of immune cells by blocking immune checkpoints, thereby restoring the anti-tumor activity of immune cells. However, immune-related adverse events are a common complication of checkpoint blockade, which might be caused by the physiological role of checkpoint pathways in regulating adaptive immunity and preventing autoimmunity. In this context, the intestinal microbiota has shown great potential in the immunotherapy of cancer. The intestinal microbiota not only regulates the immune function of the body, but also optimizes the therapeutic effect of immune checkpoint inhibitors, thus reducing the occurrence of complications. Therefore, manipulating the intestinal microbiota is expected to enhance the effectiveness of immune checkpoint inhibitors and reduce adverse reactions, which will lead to new breakthroughs in immunotherapy and cancer management.

show abstract

Membrane cholesterol plays an important role in enteropathogen adhesion and the activation of innate immunity via flagellin–TLR5 signaling

Cited by 7 publications

References 45 publications

Human Genetic Variation Influences Enteric Fever Progression

Human Genetic Variation Influences Enteric Fever Progression

Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood

Intestinal microbiota: a new force in cancer immunotherapy

Contact Info

Product

Resources

About