Membrane interactions and antimicrobial effects of inorganic nanoparticles

Häffner, Sara Malekkhaiat; Malmsten, Martin

doi:10.1016/j.cis.2017.07.029

Cited by 68 publications

(36 citation statements)

References 187 publications

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“…Complexation of biomolecules with nanoscale components can produce hybrid materials, 8 suitable for molecular sensing, drug delivery, filtration/separation, and medical imaging. 9 − 15 …”

Section: Introductionmentioning

confidence: 99%

Nanoparticles Self-Assembly within Lipid Bilayers

Chan

2018

ACS Omega

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Coarse-grained molecular dynamics simulations are used to model the self-assembly of small hydrophobic nanoparticles (NPs) within the interior of lipid bilayers. The simulation results reveal the conditions under which NPs form clusters and lattices within lipid bilayers of planar and spherical shapes, depending on the NP–lipid coupling strengths. The formation of nanopores within spherical bilayers with self-assembled planar NPs is also described. These observations can provide guidance in the preparation of functional bio-inorganic systems.

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“…Complexation of biomolecules with nanoscale components can produce hybrid materials, 8 suitable for molecular sensing, drug delivery, filtration/separation, and medical imaging. 9 − 15 …”

Section: Introductionmentioning

confidence: 99%

Nanoparticles Self-Assembly within Lipid Bilayers

Chan

2018

ACS Omega

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“…When polymers are modified by embedding certain fillers they can change antibacterial activity either by induced structural and morphological variations of the polymer, which might affect the interaction strength between the bacteria and the substrate, or by the direct action exerted on the bacteria by the filler . Besides, it is important to avoid losing other properties during the process such as mechanical ones and resistance to thermodegradation.…”

Section: Resultsmentioning

confidence: 99%

“…Research efforts in this area have been mainly focused on the development of composite materials using different kinds of nanoparticles, e.g. silver, zinc oxide and titanium dioxide …”

Section: Introductionmentioning

confidence: 99%

Nanocomposites based on low density polyethylene filled with carbon nanotubes prepared by high energy ball milling and their potential antibacterial activity

Benigno

Lorente

Olmos

et al. 2019

Polymer International

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Low density polyethylene (LDPE) based nanocomposites containing multi-walled carbon nanotubes (MWCNTs) were prepared by a two-step process consisting of a pre-mixture using high energy ball milling (HEBM) and subsequent hot pressing. The effects of ball milling and the presence of the MWCNTs on some physical properties of the materials and the antimicrobial efficiency against DH5 Escherichia coli were studied. Fourier transform infrared spectroscopy revealed that the polymer structure did not change in the final materials after the addition of MWCNTs and mixing. Differential scanning calorimetry showed small differences in the LDPE thermal behavior as a function of the type of material due to small changes in the polymer crystallization. This result was mainly ascribed to the milling process rather than to the incorporation of the MWCNTs. The presence of 1% by weight of the nanofiller increased the rigidity and hydrophobicity of the nanocomposites with respect to neat LDPE. This effect was explained by the preferential location of the MWCNTs in the surface of the material as the main factor decreasing the polar contribution to the surface free energy. A correlation between hydrophobicity, biofilm development and the shape and size of DH5 E. coli was observed, indicating that the presence of MWCNTs leads to a biocide effect by decreasing cell adhesion and changing its metabolism.

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“…One of the most frequent applications of NC is the use in tumor therapy [ 126 ] as they have many advantages over classical chemotherapeutics and other pharmacology agents like improved bioavailability [ 127 ], organ- [ 128 ] or cell type- [ 16 ] specific targeting, tunable drug release [ 129 ], and addressing of organelles [ 130 ]. The exact mode of interaction of NC with a cell membrane is strongly influenced by the size, charge, shape, and hydrophilic/hydrophobic surface properties of the former, and uptake most often occurs either by membrane penetration which is associated with transient appearance of holes or by receptor-mediated endocytosis [ 131 ]. Both cellular uptake and endosomal release of NC-complexed DNA is enhanced by cell penetrating peptides (CPP) which are either attached directly to DNA [ 132 ] or to the DNA-complexing NC [ 133 ].…”

Section: Nano-carriers For Transfer Of Dna Vaccinesmentioning

confidence: 99%

DNA Vaccines—How Far From Clinical Use?

Hobernik

Bros

2018

IJMS

388

332

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Two decades ago successful transfection of antigen presenting cells (APC) in vivo was demonstrated which resulted in the induction of primary adaptive immune responses. Due to the good biocompatibility of plasmid DNA, their cost-efficient production and long shelf life, many researchers aimed to develop DNA vaccine-based immunotherapeutic strategies for treatment of infections and cancer, but also autoimmune diseases and allergies. This review aims to summarize our current knowledge on the course of action of DNA vaccines, and which factors are responsible for the poor immunogenicity in human so far. Important optimization steps that improve DNA transfection efficiency comprise the introduction of DNA-complexing nano-carriers aimed to prevent extracellular DNA degradation, enabling APC targeting, and enhanced endo/lysosomal escape of DNA. Attachment of virus-derived nuclear localization sequences facilitates nuclear entry of DNA. Improvements in DNA vaccine design include the use of APC-specific promotors for transcriptional targeting, the arrangement of multiple antigen sequences, the co-delivery of molecular adjuvants to prevent tolerance induction, and strategies to circumvent potential inhibitory effects of the vector backbone. Successful clinical use of DNA vaccines may require combined employment of all of these parameters, and combination treatment with additional drugs.

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Membrane interactions and antimicrobial effects of inorganic nanoparticles

Cited by 68 publications

References 187 publications

Nanoparticles Self-Assembly within Lipid Bilayers

Nanoparticles Self-Assembly within Lipid Bilayers

Nanocomposites based on low density polyethylene filled with carbon nanotubes prepared by high energy ball milling and their potential antibacterial activity

DNA Vaccines—How Far From Clinical Use?

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