Membrane of hybrid chitosan–silica xerogel for guided bone regeneration

Lee, Eun Jung; Shin, Du Sik; Kim, Hyoun Ee; Kim, Hae Won; Koh, Young Hag; Jang, Jingon

doi:10.1016/j.biomaterials.2008.10.025

Cited by 232 publications

(138 citation statements)

References 31 publications

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“…An ideal periosteal graft would not only provide a physical structure that facilitates osteoconduction, but also osteoinductive signals that stimulate osteogenesis and ultimately promote biomineralization [8]. Membranes made of amniotic tissue [9], chitosan-silica [10] or silk fibroin nanofibers [11] have been reported to induce osteoblastic differentiation in vitro. Also, a variety of in vitro mineralizing membranes based on chitosan/bioactive glass nanoparticles [12], platelet-rich fibrin functionalized with alkaline phosphatase (ALK) [13], polycaprolactone fibers incorporating nano-apatite particles [14] or forsterite nanopowder [15], and collagen [16] have been developed.…”

Section: Introductionmentioning

confidence: 99%

Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane

et al. 2014

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“…The success of GBR, which is reflected by a higher regenerative potential relative to unsupported healing conditions, depends on the properties of the barrier membrane materials, particularly their interactions with osseous and surrounding tissues 31) . The membrane materials should exhibit mechanical properties compatible with bone tissue 32) , which means that the membrane requires sufficiently strong and balanced mechanical strength to maintain the space for bone regeneration during the healing process 33) . Furthermore, it should be flexible to prevent damage to surrounding tissues and facilitate surgical procedures.…”

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confidence: 99%

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

et al. 2018

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The effectiveness of a previously developed unsintered hydroxyapatite (uHA) and poly(L-lactic acid) (PLLA) hydrophilic membrane as a resorbable barrier for guided bone regeneration (GBR) was evaluated. Critical-size 8-mm diameter bone defects were surgically generated in the parietal bones of 24 12-week-old male Wistar rats, which were then divided into three groups in which either a uHA/ PLLA or a collagen membrane or no membrane (control) was placed onto the bone defect. Following sacrifice of the animals 2 or 4 weeks after surgery, bone defects were examined using microcomputed tomography and histological analysis. Bone mineral density, bone mineral content, and relative bone growth area values 2 or 4 weeks after surgery were highest in the uHA/PLLA group. Four weeks after surgery, the relative bone growth area in the uHA/PLLA group was larger than that in the collagen group. The resorbable uHA/PLLA membrane is thus potentially effective for GBR.

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“…The recently developed sol-gel technique has shown great promise for biomedical applications by offering new possibilities for embedding antibiotics within silica and for controlling their release from the host matrix into the surrounding medium (7,16,19,22,23). The composition of silica xerogels that can be tuned and the fabrication method at low temperatures enable them to carry biologically active agents and to be useful as a drug delivery system (8). Sol-gel silica materials have been shown to be biocompatible in vivo as they are readily degradable inside the body (6), which eliminates the problem of accumulation that has remained a major drawback for many other nanoparticle delivery systems.…”

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confidence: 99%

Silica-Antibiotic Hybrid Nanoparticles for Targeting Intracellular Pathogens

Seleem

Munusamy²,

Ranjan

et al. 2009

Antimicrob Agents Chemother

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We investigated the capability of biodegradable silica xerogel as a novel carrier of antibiotic and the efficacy of treatment compared to that with the same dose of free drug against murine salmonellosis. The drug molecules (31%) entrapped in the sol-gel matrix remained in biologically active form, and the bactericidal effect was retained upon drug release. The in vitro drug release profiles of the gentamicin from the xerogel and that from the xerogel-polyethylene glycol (PEG) were distinctly different at pH 7.4. A delayed release of gentamicin was observed from the silica xerogel network (57% in 33 h), and with the addition of 2% PEG, the release rate reached 90% in 33 h. Administration of two doses of the silica xerogel significantly reduced the Salmonella enterica serovar Typhimurium load in the spleens and livers of infected AJ 646 mice. The silica xerogel and xerogel-PEG achieved a 0.45-log and a 0.41-log reduction in the spleens, respectively, while for the free drug there was no reduction. On the other hand, silica xerogel and xerogel-PEG achieved statistically significant 1.13-log and 1.15-log reductions in the livers, respectively, while for the free drug the reduction was a nonsignificant value of 0.07 log. This new approach, which utilizes a room-temperature synthetic route for incorporating therapeutic drugs into the silica matrix, should improve the capability for targeting intracellular pathogens.

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Membrane of hybrid chitosan–silica xerogel for guided bone regeneration

Cited by 232 publications

References 31 publications

Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane

Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

Silica-Antibiotic Hybrid Nanoparticles for Targeting Intracellular Pathogens

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