1986
DOI: 10.1016/0014-4835(86)90039-4
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Membrane permeability characteristics of perfused human senile cataractous lenses

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Cited by 21 publications
(13 citation statements)
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“…Lenses subjected to damage then incubated for 30 min showed no detectable weight increase (data not shown). While the present studies are based on experimental maneuvers to disrupt tissue integrity and increase ion permeability, it has long been understood that cortical cataract is associated with increased ion permeability and water accumulation (Lucas et al, 1986) and even normal human lenses become detectably more cation permeable with age (Duncan et al, 1989). Pathophysiological conditions like exposure to ionizing irradiation also increase lens ion permeability and cause swelling (Lambert and Kinoshita, 1967).…”
Section: Discussionmentioning
confidence: 99%
“…Lenses subjected to damage then incubated for 30 min showed no detectable weight increase (data not shown). While the present studies are based on experimental maneuvers to disrupt tissue integrity and increase ion permeability, it has long been understood that cortical cataract is associated with increased ion permeability and water accumulation (Lucas et al, 1986) and even normal human lenses become detectably more cation permeable with age (Duncan et al, 1989). Pathophysiological conditions like exposure to ionizing irradiation also increase lens ion permeability and cause swelling (Lambert and Kinoshita, 1967).…”
Section: Discussionmentioning
confidence: 99%
“…These polyols have been reported to induce the expression of several genes mainly via the activation of OREBP and/or TonEBP, which belong to the NFAT5 family of transcription factors (13). The hyperosmotic response has been demonstrated not only in proximal tubular epithelial cells but also in other cells of the kidney as well as extrarenal tissues such as the retina and lens epithelial cells (27)(28)(29). Important to this discussion is our observation that MIOX is also expressed in epithelial cells of human lens and retina, in addition to proximal tubular epithelial cells (data not shown).…”
Section: Discussionmentioning
confidence: 99%
“…This is a solution of similar composition to the mammalian aqueous humour. The AAH used in this study represents a slight modification to that described by Lucas, Duncan & Davies (1986) and had the following composition (mM): NaCl, 124; KCI,5;NaHCO3,16;HEPES,10;CaCl2,1;MgCl2,05;and glucose,5. The AAH was warmed to 35°C and gassed with humidified 5 % C02/95 % 02, giving a final pH of 7 25.…”
Section: Methodsmentioning
confidence: 99%