Membrane Processes for Plasma Separation and Plasma Fractionation: Guiding Principles for Clinical Use

Malchesky, Paul S.

doi:10.1046/j.1526-0968.2001.00337.x

Cited by 19 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are two possibilities: (1) the pore structure and light transmittance of paper types differ from each other . The pore structure of filter paper is like a spider web, which is difficult for light to transmit, but PSM can be easily cured because of the cylindrical pore structure . Because PSM is opaque, and thick compared to the filter paper, light transmittance is low. , Although a single piece of PSM can be used to fabricate 3D-μPADs with similar patterns, the 3D-μPADs were fabricated using PSM overlaid on a filter paper to improve the limit of detection (LOD) using a high filter paper contrast ratio …”

Section: Resultsmentioning

confidence: 99%

Three-Dimensional Paper-Based Microfluidic Analytical Devices Integrated with a Plasma Separation Membrane for the Detection of Biomarkers in Whole Blood

Park

Kim

et al. 2019

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Paper-based microfluidic analytical devices (μPADs) have recently attracted attention as a point-of-care test kit because of their low cost and nonrequirement for external forces. To directly detect biomarkers in whole blood, however, they need to be assembled with a filter such as a plasma separation membrane (PSM) because the color of the blood cells interferes with the colorimetric assay. However, this assembly process is rather complicated and cumbersome, and the fluid does not uniformly move to the detection zone when the adhesion between the paper and PSM is not perfect. In this study, we report a simple three-dimensional (3D) printing method for fabricating PSM-integrated 3D-μPADs made of plastics without the need for additional assembly. In detail, PSM was coated with parylene C to prevent its dissolution from organic solvent during 3D printing. Then, the coated PSM was superimposed on the paper. Detection zones and a reservoir were printed on the paper and PSM via liquid photopolymerization, using a digital light processing printer. The limit of detection of the PSM-integrated 3D-μPADs for glucose in whole blood was 0.3 mM, and these devices demonstrated clinically relevant performance on diabetes patient blood samples. Our 3D-μPADs can also simultaneously detect multiple metabolic disease markers including glucose, cholesterol, and triglycerides in whole blood. Our results suggest that our printing method is useful for fabricating 3D-μPADs integrated with PSM for the direct detection of biomarkers in whole blood.

show abstract

Section: Resultsmentioning

confidence: 99%

Three-Dimensional Paper-Based Microfluidic Analytical Devices Integrated with a Plasma Separation Membrane for the Detection of Biomarkers in Whole Blood

Park

Kim

et al. 2019

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…The tube is then released before the polarization layer has time to accumulate followed by acceleration of the blood flow (velocity spike) which helps flush the membrane. In clinical practice, the TMP must be closely monitored and maintained below a certain critical threshold (50–100 mmHg) to prevent hemolysis and filter clotting (see Figure ) . Limiting TMP is achieved by reducing blood flow and maintaining a filtration fraction (FF), defined as the ratio of effluent rate to blood flow rate, around 20–30%.…”

Section: Membrane Propertiesmentioning

confidence: 99%

Membrane‐based Therapeutic Plasma Exchange: A New Frontier for Nephrologists

Gashti

2016

Seminars in Dialysis

View full text Add to dashboard Cite

Therapeutic plasma exchange has long been utilized to manage a variety of immune-mediated diseases. The underlying principle is the removal of a circulating pathogenic substance from the plasma and substitution with a replacement fluid. Different methodologies of plasma separation include the use of centrifuge, which relies on the variation in the specific gravity of blood components, and membrane-based separation, which relies on particle size. With advancements in technology and clinical insight into disease pathophysiology, membrane technology has become more biocompatible, safer, and more adaptable to conventional hemodialysis and hemofiltration machines. As such, nephrologists, who are familiar with management of extracorporeal blood purification systems, are increasingly involved with membrane-based plasma separation. This review aims to highlight the technical aspects of membrane-based separation, review the prescription for therapy, and draw comparisons with the centrifuge-based technique when applicable.

show abstract

“…The adsorption technologies allow the most selective separation of plasma components without the use of any substitution solution [2]. Membrane techniques are simple and safe to apply and can be competitive to other plasma separation and treatment technologies [4]. The advantages of membranes plasma exchange include its simplicity to use with blood pumps and no observed white blood cell or platelet loss, compared with centrifuges.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Apheresis in Neurology

Bambauer¹

2020

JCRR

View full text Add to dashboard Cite

Therapeutic plasma exchange (TPE) remove harmful plasma constituents from patient’s blood and replacing the extracted plasma with replacement solutions. The advantages of TPE with hollow fiber membranes are a complete separation of the corpuscular components from the plasma and due to increased blood flow rate higher efficacy. Therapeutic apheresis (TA) is used more and more throughout the world. The development of new, more sophisticated membranes and new adsorption technologies allow the most selective separation of plasma components. TA has been successfully introduced in a variety of autoantibody-mediated diseases. TA is the first- or second-line therapy in the treatment of neurological disorders. The updated information on immunology and molecular biology of different neurological diseases are discussed in relation to the rationale for apheresis therapy and its place in combination with other modern treatments. The different neurological diseases can be treated by various apheresis methods. Pathogenetical aspects are demonstrated in these diseases, in which they are clarified. TA has been shown to effectively remove the autoantibodies, immune complexes, inflammatory moderators, paraproteins, and other toxins from blood and lead to rapid clinical improvement. For the neurological diseases, which can be treated with TA, the guidelines of the Apheresis Application Committee (AAC) of the American Society for Apheresis (ASFA) are cited.

show abstract

Membrane Processes for Plasma Separation and Plasma Fractionation: Guiding Principles for Clinical Use

Cited by 19 publications

References 29 publications

Three-Dimensional Paper-Based Microfluidic Analytical Devices Integrated with a Plasma Separation Membrane for the Detection of Biomarkers in Whole Blood

Three-Dimensional Paper-Based Microfluidic Analytical Devices Integrated with a Plasma Separation Membrane for the Detection of Biomarkers in Whole Blood

Membrane‐based Therapeutic Plasma Exchange: A New Frontier for Nephrologists

Therapeutic Apheresis in Neurology

Contact Info

Product

Resources

About