Membrane-protective effect of quercetin and lipoate on the retina in streptozotocin diabetes

Moroz, О.

doi:10.31288/oftalmolzh201437680

Cited by 1 publication

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“…Assessing the results of the present paper, the role of pigment epithelium in the protection of the retinal neuroepithelium from oxidative stress should be noted. However, if the high level of free radical generating occurs, the pigment epithelium cells can be also damaged up to apoptosis develops [11].…”

Section: Resultsmentioning

confidence: 99%

“…Recent researches have evidenced the role of freeradical processes, in particular lipid peroxidation (LPO) in diabetic-related blood vessel disorders in the retina and other organs. In this regard, of immediate interest are researches on retinal pigment epithelium which state under DR condition is extremely understudied [10,11,12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Study on the effect of quercetine and lipoate on lipid peroxidation in the retina in experimental diabetes

Pasyechnikova¹,

Si²,

Moroz³

2016

Oftalmol Zh

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The experiment was performed on white rats and content of malondialdehyde and conjugated dienes in the retina and blood plasma in the condition of streptozotocineinduced diabetes development and quercetine and lipoate application was studied. In such conditions, the use of drugs studied significantly prevented an increase in temporary products of lipid peroxidation (LPO) in the retina and blood of streptozotocine-induced diabetic animals at all terms of diabetes development. The use of lipoic acid in a greater degree decreased the enrichment of final products of LPO in the retina and blood of streptozotocine-induced diabetic animals at all terms of diabetes development as compared to that when quercetine was used.

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Section: Resultsmentioning

confidence: 99%