Membrane Resting and Action Potentials of Single Cardiac Muscle Fibers of the Frog Ventricle

Woodbury, Lowell A.; Hecht, Hans H.; Christopherson, A. Rodney

doi:10.1152/ajplegacy.1951.164.2.307

Cited by 108 publications

(24 citation statements)

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“…The finding that the spike is associated with a profound decrease of the membrane resistance agrees with similar results obtained on the alga Nitella (Blin s, 1936; Cole & Curtis, 1938), the giant axon of the squid (Cole & Curtis, 233 SILVIO WEIDMANN 1939), skeletal muscle (Katz, 1941) and myelinated nerve (Tasaki & Mizuguchi, 1949 Meek, 1942), nor in that of the frog ventricle (Woodbury et al 1951). Recent experiments with nerve and muscle indicate that the rising phase of the action potential is brought about by an increase in permeability which allows sodium ions to enter the fibre at a high rate (for references see Hodgkin, 1951;Huxley & Stampfii, 1951).…”

Section: Discussionsupporting

confidence: 84%

Effect of current flow on the membrane potential of cardiac muscle

Weidmann¹

1951

The Journal of Physiology

463

233

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Section: Discussionsupporting

confidence: 84%

Effect of current flow on the membrane potential of cardiac muscle

Weidmann¹

1951

The Journal of Physiology

463

233

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“…(ii) The divalent cations, which are particularly potent in depressing the spike and the resting potential, usually decrease the latter much more than do the monovalent ions (Tables III and IV (48). The potentials recorded were essentially independent of the type of junction used in the measurement (Table III), and of the period elapsed after isolation of the axon (Table I).…”

Section: Differences In Effezts Of Differentmentioning

confidence: 98%

Bioelectric Effects of Ions Microinjected Into the Giant Axon of Loligo

Grundfest

Kao

Altamirano

1954

Journal of General Physiology

103

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1. A technique is described for recording the bioelectric activity of the squid giant axon during and following alteration of the internal axonal composition with respect to ions or other substances. 2. Experimental evidence indicates that the technique as described is capable of measuring changes in local bioelectric activity with an accuracy of 10 to 15 per cent or higher. 3. Alterations of the internal K+ or Cl- concentrations do not cause the change in resting potential expected on the basis of a Donnan mechanism. 4. The general effect of microinjection of K+ Rb+, Na+, Li+, Ba++, Ca++, Mg++, or Sr++ is to cause decrease in spike amplitude, followed by propagation block. 5. The resting potential decreases when the amplitude of the spike becomes low and block is incipient. 6. The decrease in resting potential and spike amplitude may be confined to the immediate vicinity of the injection. 7. At block, the resting potential decreases up to 50 per cent, but injection of small quantities of divalent cations may cause much larger localized depolarization. 8. The blocking effectiveness of K+, Na+, and Ca++ expressed as reciprocals of the relative amounts needed to cause block is approximately 1:5:100. Rb+ has the same low effectiveness as does K+. Li+ resembles Na+. Ba++ and Mg++ are approximately as effective as Ca++. 9. Microinjection of Na+ may cause marked prolongation of the spike at the injection site as well as decrease in its amplitude. 10. The anions used (Cl-, HCO3-, NO3-, SO4-, aspartate, and glutamate) do not seem to exert specific effects. 11. A tentative explanation is offered for the insensitivity of the resting potential to changes in the axonal ionic composition. 12. New data are presented on the range of variation, in a large sample, of the magnitude of the resting potential and spike amplitude.

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“…The time course of the response of tetanized nerve fibers is similar to the time course of the response of cardiac muscle fibers (18), of Purkinje fibers (3), of crustacean muscle fibers treated with TEAC (4), and of nerve fibers treated with NaC1 (hypertonic), sinomenine, heroine, brucine, emetine (14), or azide (unpublished experiments).…”

Section: Discussionmentioning

confidence: 55%

Changes in the Duration of the Electric Response of Single Nerve Fibers Following Repetitive Stimulation

Spyropoulos

1956

The Journal of General Physiology

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Single nerve fibers were isolated from the nerve innervating the sartorius or semitendinosus muscle of the toad (Bufo marinus). Single nerve fiber responses were recorded with three arrangements of the "bridge insulator" method. During stimulation at 50 to 150 pulses per second for 20 to 140 minutes the spike duration was progressively increased. After tetanization the spike duration usually continued to increase at a more rapid rate. Within 5 to 60 minutes further prolongation stopped and within 1 to 10 hours the spike duration was normal. The duration of the response of tetanized fibers was from 2.5 to more than 10 times the spike duration of untetanized fibers. Prolongation was observed in nerve fibers isolated from nerves tetanized in vivo.

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Membrane Resting and Action Potentials of Single Cardiac Muscle Fibers of the Frog Ventricle

Cited by 108 publications

References 0 publications

Effect of current flow on the membrane potential of cardiac muscle

Effect of current flow on the membrane potential of cardiac muscle

Bioelectric Effects of Ions Microinjected Into the Giant Axon of Loligo

Changes in the Duration of the Electric Response of Single Nerve Fibers Following Repetitive Stimulation

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