Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1–WAVE2–kinesin complex

Takahashi, Kyoko; Suzuki, Katsuo

doi:10.1016/j.cellsig.2009.01.007

Cited by 44 publications

(49 citation statements)

References 41 publications

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“…Previous investigation shows that stathmin not only plays an important role in cell proliferation and motility but also participates as a “relay protein” in several intracellular cancer related signaling pathways, such as the Hedgehog signaling pathway [24], p53 pathway [16] and Pak1-WAVE2-kinesin complex [25]. Although many studies have identified that stathmin is involved in the activation and inactivation of motility in tumor pathological process [6, 12, 15–18, 23], much still has not be disclosed pertaining the molecular signally pathways how stathmin performs the role.…”

Section: Discussionmentioning

confidence: 99%

Stathmin overexpression is associated with growth, invasion and metastasis of lung adenocarcinoma

Lin

Biaoxue

et al. 2016

Oncotarget

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Stathmin has been investigated as a tumor biomarker because it appear to be associated with tumorigenesis; however, the effect of stathmin in lung adenocarcinoma (LAC) remains poorly understood. The purpose of this study was to examine the expression of stathmin in lung adenocarcinoma, and to disclose the relationship between them. The expression of stathmin was examined by RT-PCR, IHC and Western blot. Furthermore, small interfering RNA (shRNA)-mediated silencing of stathmin was employed in LAC cells to investigate cell proliferation, invasion and apoptosis. In this study, we showed that overexpression of stathmin was significantly associated with poorly differentiated, lymph node metastasis and advance TNM stages of lung adenocarcinoma. And silencing of stathmin expression inhibited the proliferation, migration and invasion of lung adenocarcinoma PC-9 cells, and retarded the growth of PC-9 cells xenografts in nude mice. Additionally, the anticarcinogenic efficacy of stathmin silencing might be involved in P38 and MMP2 signaling pathways. In conclusion, these results showed that stathmin expression was significantly up-regulated in LAC, which may act as a biomarker for LAC. Furthermore, silence of stathmin inhibiting LAC cell growth indicated that stathmin may be a promising molecular target for LAC therapy.

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Section: Discussionmentioning

confidence: 99%

Stathmin overexpression is associated with growth, invasion and metastasis of lung adenocarcinoma

Lin

Biaoxue

et al. 2016

Oncotarget

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“…16,17 WAVE2 participates in multiple processes related to actin dynamics, such as lamellipodia and filopodium formation, 18,19 cell migration and protrusion, [20][21][22] and embryogenesis.…”

Section: Wave2 Regulates Meiotic Spindle Stability Peripheral Positimentioning

confidence: 99%

“…[38][39][40][41] Localization of γ-tubulin and MAPK was disrupted by WAVE2 RNAi, an indication that spindle formation was disrupted. Recent work showed that PAK1, the downstream effector of Rac, could form a WAVE2-PAK1-kinesin complex 18,38 and that PAK1 …”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes

Sun¹,

Xu²,

Li³

et al. 2011

Cell Cycle

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“…Alternatively, stathmin 3 may be partially targeted to the leading edge of neurites upon phosphorylation at serine 60. Such a process has been recently shown for stathmin 1 through its association to a specific kinesin complex when phosphorylated at serine 38 (63,64).…”

Section: Bmentioning

confidence: 78%

Specific Serine-Proline Phosphorylation and Glycogen Synthase Kinase 3β-directed Subcellular Targeting of Stathmin 3/Sclip in Neurons

Devaux

Poulain²,

Devignot

et al. 2012

Journal of Biological Chemistry

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Background: Stathmins are involved in the control of neuronal differentiation. Results: Stathmin 3 displays specific phosphorylation patterns by ERK2 and CDK5 and is a unique stathmin substrate for glycogen synthase kinase 3␤ mostly at neurite tips. Conclusion: Stathmin proteins can be specifically and locally regulated by proline-directed phosphorylation. Significance: Molecular and subcellular regulation of stathmins may contribute to the control of the development and plasticity of the nervous system.

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Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1–WAVE2–kinesin complex

Cited by 44 publications

References 41 publications

Stathmin overexpression is associated with growth, invasion and metastasis of lung adenocarcinoma

Stathmin overexpression is associated with growth, invasion and metastasis of lung adenocarcinoma

WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes

Specific Serine-Proline Phosphorylation and Glycogen Synthase Kinase 3β-directed Subcellular Targeting of Stathmin 3/Sclip in Neurons

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