Membranoproliferative Glomerulonephritis Associated with a Mixed-Cell Germinal Ovary Tumor

Salazar-Exaire, D.; Rodríguez, A.; Galindo-Rujana, M.E.; Briones, J.C.; Arenas-Osuna, Jesús; Rocha, Lauren; Paniagua, Ramón

doi:10.1159/000046219

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…A causative relationship between nephrotic syndrome and tumors would be indicated by the clinical remission of the nephrotic syndrome following the complete removal of the tumor without any additional therapy. But in some cases of nephrotic syndrome associated with ovarian tumors, the treatment has included the administration of corticosteroid with surgical removal of the tumor [2,13]. Surgery and/or chemotherapy and/or corticosteroids combination makes unclear the relationship between the remission of both tumor and nephrotic syndrome (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…Remission of the NS was seen in 10 cases that achieved successful treatment of ovarian tumor. One patient obtained remission of nephrotic syndrome by excision alone [11], while remission is achieved with chemotherapy alone in another case [16] and by excision with chemotherapy in three other cases [9,14] On the other hand, remission of the NS was not achieved in two patients with ovarian tumor (mixed germ cells and dermoid cyst) treated with prednisone and excision [2,13] .Treatment and outcome could not be analyzed in the other cases due to incomplete information[10]. In our patient, surgical resection of the ovarian tumor, and corticosteroid treatment resulted in briskly and complete remission of the nephrotic syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Ovarian tumor and glomerulopathies: case report and review of the literature

Benabdellah¹,

Izzedine²,

Bentata³

et al. 2019

Pan Afr Med J

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We describe a patient who developed nephrotic syndrome in the setting of ovarian tumor. A kidney biopsy showed minimal change nephropathy (MCN). CT scan and MR imaging followed by surgery lead to diagnostic of ovarian dermoid cyst. Surgery combined with corticosteroids resulted in a complete remission of nephrotic syndrome with disappearance of proteinuria after 3 weeks. Ten other cases of ovarian tumor associated with glomerulopathy are reviewed. This is the second case of an ovarian teratoma associated with MCN. Accurate history, physical examination, laboratory data, and kidney biopsy are highlighted in establishing the correct diagnosis in such patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ovarian tumor and glomerulopathies: case report and review of the literature

Benabdellah¹,

Izzedine²,

Bentata³

et al. 2019

Pan Afr Med J

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“…Nephrotic syndrome is a well described paraneoplastic phenomenon which usually resolves with treatment of the primary tumour. It has been linked to malignant ovarian tumours, both carcinomas 36 , 37 and germ cell tumours 38 . There is only one case of nephrotic syndrome associated with a benign ovarian tumour in the literature.…”

Section: Discussionmentioning

confidence: 99%

The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient

Mall

Tyler²,

Lotz³

et al. 2007

Int. J. Med. Sci.

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Introduction: The presence of MUC5AC (M1 antigen) and MUC6 have previously been found in ovarian mucinous cyst. We characterized the mucins in the crude mucus and tissue of a mature ovarian teratoma in an 8 year old girl. Materials and Methods: Mucins were purified from crude mucus by density gradient ultra-centrifugation in CsCl and analysed by gel-filtration and SDS-PAGE analysis. Mucin identification and expression was by western blotting and immunohistochemistry. Results: Histology showed a tumour with solid and cystic areas, with the cysts lined by colonic and respiratory mucosae. Equal volumes of 'sol' and 'gel' phases of approximately 10.0ml of crude mucus were obtained. Gel filtration and SDS-PAGE analyses suggested that the mucin was mainly of the large polymeric type which dissociated upon reduction of disulphide bonds with DTT. The colonic and respiratory epithelia predominantly expressed acidic mucin of the sialated and sulphated types respectively. MUC1 and MUC1c were expressed exclusively in respiratory epithelium, MUC2 and some MUC6 (focal) in the colonic tissue and MUC5AC in both tissues. Western blotting confirmed the presence of MUC2, MUC5AC and MUC5B in the secreted gel. Serine, threonine and proline made up the bulk of the amino acids in the sample. Discussion: Ovarian teratoma produced a highly viscous mucus secretion in which the mucin was largely polymeric and of the MUC2, MUC5AC and MUC5B type. The respiratory component of the teratoma expressed MUC1 and MUC1c and the colonic components of the teratoma expressed MUC2 and some MUC6. MUC5AC was expressed in both components.

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