Membranoproliferative Glomerulonephritis Associated with Psoriasis Vulgaris

Akoglu, Hadim; Dede, Fatih; Akoğlu, Gülşen; Gönül, İpek Işık; Odabaş, Ali Rıza

doi:10.3109/08860220903180582

Cited by 15 publications

(10 citation statements)

References 18 publications

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“…[40][41][42][43][44] Minimal nephrotic syndrome changes were also shown to precede or occur simultaneously with psoriasis in a case series of children. [40][41][42][43][44] Minimal nephrotic syndrome changes were also shown to precede or occur simultaneously with psoriasis in a case series of children.…”

Section: Discussionmentioning

confidence: 87%

“…Prior small case studies have suggested that various types of GN, such as IgA nephropathy, membranous glomerulopathy and focal segmental glomerulonephritis, may be more likely to occur in patients with psoriasis. [40][41][42][43][44] Minimal nephrotic syndrome changes were also shown to precede or occur simultaneously with psoriasis in a case series of children. 45 Moreover, because GN may progress to CKD or late stage CKD (ESRD) and the diagnosis of CKD is made on the basis of abnormal urinalysis and glomerular filtration rate results without knowledge of the specific cause, 46 we further investigated the relationship among GN, ESRD and psoriasis.…”

Section: Discussionmentioning

confidence: 87%

See 1 more Smart Citation

Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study

Chiu

Huang

et al. 2015

Br J Dermatol

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 87%

Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study

Chiu

Huang

et al. 2015

Br J Dermatol

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“…There are some reports that psoriasis is associated with glomerular disease. IgAN is the most frequent [6], and mesangial proliferative nephritis [7], amyloidosis [8], focal segmental glomerulosclerosis [9], minimal change disease [10], and membranoproliferative glomerulonephritis [11] have also been reported. However, as far as GPP is concerned, there are few reports of glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

IgA nephropathy in a patient receiving infliximab for generalized pustular psoriasis

et al. 2020

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Background: IgA nephropathy is the most common glomerulonephritis. Secondary IgA nephropathy complicated with systemic diseases, including psoriasis, is also often reported. Generalized pustular psoriasis is a form of psoriasis characterized by sterile pustules on reddened skin and fever. Infliximab, one of the first-line therapies for severe psoriasis, has also been reported to cause systemic vasculitis and IgA nephropathy. We herein report a case of IgA nephropathy activated during infliximab treatment for generalized pustular psoriasis. Case presentation: A 28-year-old woman presented with episodic gross hematuria, increasing proteinuria, and renal dysfunction. She had been receiving anti-TNFα therapy with infliximab because of generalized pustular psoriasis for 3 years, but her skin symptoms worsened following withdrawal during pregnancy. After delivery, her skin symptoms improved with the resumption of infliximab, but clinical signs suggested glomerulonephritis, and renal biopsy showed active IgA nephropathy. Infliximab was discontinued, and the combination of corticosteroids, tonsillectomy, and secukinumab, an IL-17A inhibitor, improved both the skin symptoms and the glomerulonephritis. Conclusions: In our case, the activity of IgA nephropathy was exacerbated by anti-TNFα therapy but was improved by the combination of corticosteroids, tonsillectomy, and an IL-17A inhibitor against the original disease. Autoimmune diseases may underlie the development of secondary IgA nephropathy associated with anti-TNFα therapy, and so further studies are needed to better understand the association between molecular-targeted drugs and IgA nephropathy.

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“…Nephropathy associated with psoriasis has been increasingly reported in recent years. These kidney diseases include IgA nephropathy [29, 30], MN [11–14], membranoproliferative glomerulonephritis [31], focal segmental glomerulosclerosis [32], minimal change disease [33], AA-amyloidosis [34], and therapy-related tubular-interstitial alteration [26]. …”

Section: Discussionmentioning

confidence: 99%

PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy

Jin

Zeng

et al. 2016

BMC Nephrol

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BackgroundThe association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis.MethodsA total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled. The clinical and pathological features were retrospectively analyzed. Serum anti-PLA2R antibody was measured using IFA Mosaic. Renal tissue samples stored in the laboratory bio-bank were used for PLA2R staining under immunofluorescence microscopy and THSD7A immunohistochemical analysis.ResultsTwenty-four patients (21 male and 3 female) with a mean age of 43.6 ± 15.7 years old were enrolled. Serum anti-PLA2R antibody was positive in 7 patients, which was significantly lower than the positivity observed in idiopathic MN (29.2% vs. 81.7%, P < 0.001). Glomerular PLA2R staining was positive in 7 patients with positive serum anti-PLA2R antibody. THSD7A staining was negative in all 24 patients. During the follow-up visits, 13 patients with negative serum PLA2R antibody achieved CR. In contrast, CR was only achieved in 1 patient with positive serum PLA2R antibody, PR was achieved in 2 patients.ConclusionsThe prevalence of serum anti-PLA2R antibody and glomerular expression of PLA2R was significantly lower in patients with psoriasis and MN than in those with idiopathic MN, and THSD7A staining was negative, suggesting that MN is associated with psoriasis in the majority of patients. However, idiopathic MN might also accompany psoriasis in a minority of psoriatic patients with positive serum anti-PLA2R antibody.

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Membranoproliferative Glomerulonephritis Associated with Psoriasis Vulgaris

Cited by 15 publications

References 18 publications

Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study

Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study

IgA nephropathy in a patient receiving infliximab for generalized pustular psoriasis

PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy

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