Membranous nephropathy after a recent SARS-CoV-2 infection

Mateus, Catarina; Manso, Rita; Martins, Ana Rita; Branco, Patrícia

doi:10.1136/bcr-2022-252468

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…Viruses can trigger immune-mediated kidney disease flare-up, nephrotic syndrome, and acute rejection in transplant patients. Accordingly, recent studies have indicated that SARS-CoV-2 infection possibly causes similar consequences in children [17][18][19][20][21]. This situation is one of the important negativities caused by COVID-19, such as acute disease and post-COVID conditions.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination among adolescents and young adults with chronic kidney conditions: a single-center experience

Baltu,

Kurt-Sukur,

Tastemel Ozturk

et al. 2024

Klin Padiatr

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Background Following the pandemic of COVID-19, the main focus has been on COVID-19 vaccines and herd immunity. Although the safety of the COVID-19 vaccines has been shown in clinical trials, children with chronic diseases were not included. We investigated the side effect profile and safety of the COVID-19 vaccines in adolescents with kidney disease. Methods A questionnaire including demographic information, history of COVID-19, vaccination status, and vaccine-related side effects was administered to the patients with chronic kidney disease (CKD) stage 2–5, glomerular disease treated with immunosuppression, and kidney transplant recipients. Results Ninety-eight patients were vaccinated with CoronaVac-inactivated SARS-CoV-2 (n=16) or BNT162b2 messenger RNA (mRNA) COVİD-19 (n=82) vaccine. The mean age was 16.90±2.36 years. The most common side effects were local pain, fatigue, and fever. No serious side effects or renal disease flare were observed. There was no significant difference in the side effects reported after the BNT162b2 mRNA-RNA as compared to the Corona Vac-inactivated SARS-CoV-2 vaccine. No significant relationship was found between the frequency of side effects according to age, glomerular filtration rate, immunosuppressive treatments, CKD stage, and the underlying disease. Conclusion Although the reported data are subjective because they were obtained through a questionnaire and studies with long-term follow-up are needed, our early experience suggests that the vaccine is safe and adolescents and young adults should be encouraged to be vaccinated.

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Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination among adolescents and young adults with chronic kidney conditions: a single-center experience

Baltu,

Kurt-Sukur,

Tastemel Ozturk

et al. 2024

Klin Padiatr

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“… 42 There are reports of MN cases that occurred in temporal relationship with COVID-19 (23 cases) but only 7 cases have clinical information available. 18 , 43 , 44 , 45 , 46 , 47 Pathophysiology of MN in COVID-19 remains unclear but may be related to immune dysregulation resulting in auto-antibodies production. 46 …”

Section: Kidney Pathology Potentially Related To Covid-19mentioning

confidence: 99%

“…There were 4 patients (66.7%) that received immunosuppression: one with tacrolimus, one with cyclophosphamide, one with methylprednisolone, and one with rituximab. 18 , 44 , 45 , 46 Two patients received conservative management. Two patients (40%) required dialysis and eventually died.…”

Section: Kidney Pathology Potentially Related To Covid-19mentioning

confidence: 99%

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COVID-19 and Glomerular Diseases

Klomjit¹,

Zand²,

Cornell³

et al. 2023

Kidney International Reports

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“…Therefore, it is highly critical to investigate the relationship between COVID-19 and kidneyrelated diseases. Initial research focused on the correlation between COVID-19 and AKI; however, emerging studies have indicated the potential onset or recurrence of glomerular diseases following COVID-19, including collapsing glomerulopathy, IgA nephropathy, and membranous nephropathy (MN) (5)(6)(7)(8)(9)(10). MN is a prevalent and clinically signi cant glomerular disorder with complex pathogenesis; it involves the production of autoantibodies against podocyte antigens localized on the glomerular basement membrane (11).…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between COVID-19 and membranous nephropathy: A bidirectional Mendelian randomization study

Zhou,

Zhang,

Zhao

et al. 2024

Preprint

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Recent studies have suggested a potential link between COVID-19 and the initiation or exacerbation of membranous nephropathy (MN) caused by the SARS-CoV-2 virus. However, a causal relationship between COVID-19 and MN remains unconfirmed. Here, we used the Mendelian randomization (MR) approach to investigate whether this causal relationship exists. We utilized data from the COVID-19 Host Genetics Initiative, comprising the largest available genome-wide association study (GWAS) datasets from European and East Asian populations. For MN, we used the largest literature-reported GWAS dataset. We selected single nucleotide polymorphisms as instrumental variables and used the inverse variance weighted (IVW) method, supplemented with MR Egger, weighted median, and mode methods. The MR-Egger intercept test and the MR-PRESSO global test were applied to assess horizontal pleiotropy. The robustness of the MR findings was evaluated using Cochran’s Q test and leave-one-out analysis. In both cohorts, MR methods showed SARS-CoV-2 infection, hospitalization, and severe COVID-19 did not increase the risk of MN. Conversely, MN potentially increased the risk of COVID-19-related hospitalization in Europeans, supported by the IVW and other methods. In East Asians, MR Egger suggested an increased risk of severe COVID-19 associated with MN, but other MR methods did not support this. No significant evidence of horizontal pleiotropy was detected. Cochran’s Q test showed no heterogeneity, and leave-one-out analysis confirmed the MR findings' reliability. The bidirectional MR analysis confirmed that COVID-19 did not increase MN risk, but MN might increase the risk of COVID-19-related hospitalization in Europeans, indicating a potential causal relationship.

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Membranous nephropathy after a recent SARS-CoV-2 infection

Cited by 4 publications

References 6 publications

COVID-19 vaccination among adolescents and young adults with chronic kidney conditions: a single-center experience

COVID-19 vaccination among adolescents and young adults with chronic kidney conditions: a single-center experience

COVID-19 and Glomerular Diseases

Causal relationship between COVID-19 and membranous nephropathy: A bidirectional Mendelian randomization study

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