Membranous Nephropathy after Bone Marrow Transplantation in Ciclosporin Treatment

Müller, Gerhard A.; Müller, Claudia; Markovic-Lipkowski, Jasmina; Bross-Bach, Ulrike; Schmidt, Helmuth; Ehninger, Gerhard; Böhle, A.; Risler, T.

doi:10.1159/000185396

Cited by 40 publications

(22 citation statements)

References 3 publications

(3 reference statements)

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“…[16][17][18][19][20][21][22][23][24][25][26][27][28] In all these reports, similar to our series, the most common pathological finding on renal biopsy was membranous glomerulonephritis (11 of the 13) and much less commonly minimal change disease (two of 13). The diseases for which transplantation was performed included chronic myeloid leukemia, multiple myeloma, aplastic anemia and acute leukemia.…”

Section: Discussionsupporting

confidence: 80%

Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Reddy

Johnson

Uberti

et al. 2006

Bone Marrow Transplant

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Section: Discussionsupporting

confidence: 80%

Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Reddy

Johnson

Uberti

et al. 2006

Bone Marrow Transplant

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“…Preliminary results of this study were presented in poster format at the American Society of Nephrology Annual Meeting, Philadelphia, PA, November 8 to 13, 2005.…”

mentioning

confidence: 99%

Nephrotic Syndrome after Hematopoietic Cell Transplantation

Brukamp¹,

Doyle²,

Bloom³

et al. 2006

Clinical Journal of the American Society of Nephrology

138

134

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Glomerular disease associated with nephrotic syndrome has rarely been recognized as a distinct complication of allogeneic hematopoietic cell transplantation. Case reports in the English and Japanese literature since 1988 have described variable glomerular histology, comprising mainly membranous glomerulonephritis (MGN) in almost two thirds and minimal change disease (MCD) in nearly one quarter of patients. Review of the literature reveals a close temporal relationship between the development of nephrotic syndrome shortly after cessation of immunosuppression and the diagnosis of chronic graft-versushost disease (GVHD). An association of glomerular disease with simultaneous GVHD was seen in 47% of patients overall. Nephrotic syndrome followed GVHD within 5 months in 60% of the combined MCD and MGN reports. A decrease in immunosuppressive medication use was linked to nephrotic syndrome occurrence within 9 months in 63% of patients with MCD and MGN. MCD occurred earlier after hematopoietic cell transplantation, was diagnosed sooner after medication change, and exhibited a better prognosis in comparison with MGN. Glomerular lesions after hematopoietic cell transplantation may therefore represent the renal manifestation of GVHD. Further studies are warranted to delineate the pathogenesis of this complication.

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“…Membranous glomerulonephritis has been found in the majority of patients and one case has described minimal change nephrotic syndrome. [3][4][5][6][7] Here, we present a typical case of NS, with an unusual morphological feature in the setting of well-documented chronic GVHD. A 26-year-old white man with AAS underwent a related identical HLA BMT in January 1994.…”

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confidence: 99%

Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

Oliveira

Bahia

Franco

et al. 1998

Bone Marrow Transplant

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Summary:GVHD is one of the most frequent complications of BMT and recently nephrotic syndrome (NS) has been described as a manifestation of chronic GVHD. Here, we present an AA patient who developed NS 1 year after BMT when cyclosporine was stopped. Renal biopsy showed focal sclerosis associated with membranous deposits. He also had other clinical manifestations of chronic GVHD: sicca-like syndrome and colestasis. After 15 days of CsA therapy, he experienced a remarkable improvement in the NS and GVHD as a whole. We comment on immunological mechanisms that could be involved in the pathogenesis of this manifestation.

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Membranous Nephropathy after Bone Marrow Transplantation in Ciclosporin Treatment

Cited by 40 publications

References 3 publications

Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Nephrotic Syndrome after Hematopoietic Cell Transplantation

Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

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