We study the effect of heterogeneous temporal activations on epidemic spreading in temporal networks. We focus on the susceptible-infected-susceptible (SIS) model on activity-driven networks with burstiness. By using an activity-based mean-field approach, we derive a closed analytical form for the epidemic threshold for arbitrary activity and inter-event time distributions. We show that, as expected, burstiness lowers the epidemic threshold while its effect on prevalence is twofold. In low-infective systems burstiness raises the average infection probability, while it weakens epidemic spreading for high infectivity. Our results can help clarify the conflicting effects of burstiness reported in the literature. We also discuss the scaling properties at the transition, showing that they are not affected by burstiness.as in Poisson processes but, typically, it features a fat tail, easily measured from large datasets [1,2].Recent studies have addressed the problem of the origin of this highly heterogeneous behavior, arising from the decision-based queuing process that humans apply in performing tasks and allocating their priority [5,6]. Besides, a large amount of work has been devoted to clarify the effects of intermittent patterns on the temporal structures of interactions, as described by temporal networks [7]. Bursty dynamics can indeed influence the structure of links on the local and on the global scale [8][9][10][11][12]. More importantly, heterogenous temporal patterns in the evolution of time-varying networks can affect in a non-trivial way dynamical processes. Analytical arguments [13][14][15] and numerical approaches [16,17] have indeed shown that burstiness can significantly modify processes mediated by interactions, such as random walks, epidemics, information diffusion, consensus formation, percolation. Among these, epidemic spreading is one of the most representative and widely applicable example [18]. Analytical results on epidemics in temporal network have focused on the epidemic threshold [19,20], in general pushed to lower values by bursty effects. In other works, burstiness is introduced on a static network as a non-Markovian effect in infection (or recovery) processes [21][22][23][24][25].Interestingly, when comparing bursty with Poisson dynamics in epidemics, conflicting observations have been reported. On the one hand, numerical results [14,16,17] and modeling techniques [15,24,26,27] provided strong evidence of a slowing down for the late time spreading in the presence of burstiness, while opposite effects are reported in the early-time dynamics [28]. In [14] and [16], burstiness is found to slow down spreading in early times, while other works observe the opposite effect [17,26].To understand such conflicting observations and keep track at the same time of the temporal evolution of interactions, in this paper we focus on the Susceptible-Infected-Susceptible (SIS) process in the presence of burstiness on activity-driven networks [29][30][31]. In activity-driven networks, the propensity to engage...