Memory and processing speed impairments in first-episode drug-naïve patients with major depressive disorder

Hu, Yu‐Chen; Li, Jin; Zhao, Youjin; Dong, Zaiquan; Qiu, Peiyuan; Xu, Huiling; Kuang, Weihong; Gong, Qiyong

doi:10.1016/j.jad.2022.10.048

Cited by 8 publications

(4 citation statements)

References 52 publications

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“…Macrovascular complications encompass cardiovascular and cerebrovascular diseases. [ 29 ] The integrity of neurovascular units, responsible for regulating cerebral blood flow, is compromised in diabetes. Structural changes in microvasculature, including capillary reduction and arteriovenous shortcuts, affect nerve tissue nutrient delivery.…”

Section: Contributing Factors To Diabetes-related Cognitive Impairmentmentioning

confidence: 99%

“…The APOE ε4 allele has long been recognized as a significant genetic risk factor for AD. [ 29 ] For example, when individuals with diabetes carry this allele, it appears to elevate their risk of cognitive impairment even further. This suggests a synergistic effect between diabetes-related metabolic disruptions and genetic susceptibility.…”

Section: Future Directions and Research Prospectsmentioning

confidence: 99%

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The impact of diabetes in cognitive impairment: A review of current evidence and prospects for future investigations

Aderinto,

Olatunji,

Abdulbasit

et al. 2023

Medicine

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Cognitive impairment in individuals with diabetes represents a multifaceted and increasingly prevalent health concern. This review critically examines the current evidence regarding the intricate relationship between diabetes and cognitive decline. It highlights the existing knowledge on the impact of diabetes on cognitive function, spanning from mild cognitive impairment to dementia, including vascular and Alzheimer dementia. The review underscores the need for a standardized diagnostic paradigm and explores research gaps, such as the implications of cognitive impairment in younger populations and various diabetes types. Furthermore, this review emphasizes the relevance of diabetes-related comorbidities, including hypertension and dyslipidemia, in influencing cognitive decline. It advocates for a comprehensive, interdisciplinary approach, integrating insights from neuroscience, endocrinology, and immunology to elucidate the mechanistic underpinnings of diabetes-related cognitive impairment. The second part of this review outlines prospective research directions and opportunities. It advocates for longitudinal studies to understand disease progression better and identifies critical windows of vulnerability. The search for accurate biomarkers and predictive factors is paramount, encompassing genetic and epigenetic considerations. Personalized approaches and tailored interventions are essential in addressing the substantial variability in cognitive outcomes among individuals with diabetes.

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Section: Contributing Factors To Diabetes-related Cognitive Impairmentmentioning

confidence: 99%

Section: Future Directions and Research Prospectsmentioning

confidence: 99%

The impact of diabetes in cognitive impairment: A review of current evidence and prospects for future investigations

Aderinto,

Olatunji,

Abdulbasit

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…In both MDD animal models and patients, various types of cognitive deficits have been widely observed, such as attenuated memory performance [ 11 , 12 ]. Short-term and long-term memory have been manifested to involve different neural systems [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

Wu,

Zhang

2023

J Neuroinflammation

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As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of premature death and other medical conditions for patients. Neuroinflammation is the abnormal immune response in the brain, and its correlation with MDD is receiving increasing attention. Neuroinflammation has been reported to be involved in MDD through distinct neurobiological mechanisms, among which the dysregulation of neurogenesis in the dentate gyrus (DG) of the hippocampus (HPC) is receiving increasing attention. The DG of the hippocampus is one of two niches for neurogenesis in the adult mammalian brain, and neurotrophic factors are fundamental regulators of this neurogenesis process. The reported cell types involved in mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, and peripheral immune cells which selectively penetrate the blood–brain barrier and infiltrate into inflammatory regions. This review summarizes the functions of the hippocampus affected by neuroinflammation during MDD progression and the corresponding influences on the memory of MDD patients and model animals.

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“…However, heterogeneity regarding cognitive impairment has been mentioned in patients with MDD, in particular executive functions ( 25 , 26 ). One study revealed that some medication-free depressed individuals showed significant reductions in executive function ( 27 ), whereas others showed subtle or no executive function deficits ( 26 , 28 ). Symptom severity, the number of previous depressive episodes, a higher level of resistance to antidepressant strategies, level of education, and age may, to some extent, explain the heterogenic cognitive profile ( 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship of insight to neurocognitive function and risk of recurrence in depression: A naturalistic follow-up study

Wang

Liu²,

Yang³

et al. 2023

Front. Psychiatry

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IntroductionMajor depressive disorder (MDD) is a highly recurrent mental illness accompanied by impairment of neurocognitive function. Lack of insight may affect patients’ motivation to seek treatment, resulting in poor clinical outcomes. This study explores the relationship of insight to neurocognitive function and the risk of recurrence of depressive episodes in patients with MDD.MethodsDemographic, clinical variables, and neurocognitive function measured with Intra-Extra Dimensional Set Shift (IED) from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were collected from 277 patients with MDD. Among them, 141 participants completed a follow-up visit within 1–5 years. Insight was measured using the 17-item Hamilton Depression Rating Scale (HAM-D). To explore the factors associated with recurrence, binary logistic regression models were used.ResultsPatients with MDD, without insight, had significantly higher total and factor scores (anxiety/somatization, weight, retardation, and sleep) on the HAM-D and worse performance in the neurocognition task, compared to those with insight. Furthermore, binary logistic regression revealed that insight and retardation can predict recurrence.ConclusionLack of insight is associated with recurrence and impaired cognitive flexibility in patients with MDD.

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Memory and processing speed impairments in first-episode drug-naïve patients with major depressive disorder

Cited by 8 publications

References 52 publications

The impact of diabetes in cognitive impairment: A review of current evidence and prospects for future investigations

The impact of diabetes in cognitive impairment: A review of current evidence and prospects for future investigations

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

Relationship of insight to neurocognitive function and risk of recurrence in depression: A naturalistic follow-up study

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