Memory B lymphocytes migrate to bone marrow in humans

Paramithiotis, Eustache; Cooper, Max D.

doi:10.1073/pnas.94.1.208

Cited by 125 publications

(98 citation statements)

References 39 publications

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“…This raises a number of unresolved questions on the mutual relationship of these two subsets of IgD low SE B cells. Two groups independently reported the existence of IgM ϩ IgD ϩ memory B cells in the human bone marrow and peripheral blood, respectively (55,57). These cells had an overall percentage of V gene mutations comparable to that of the resting CD27 high -IgD low SE B cells described here and, at least in the case of peripheral blood B cells, a comparable phenotype (57).…”

Section: Discussionmentioning

confidence: 91%

“…Two groups independently reported the existence of IgM ϩ IgD ϩ memory B cells in the human bone marrow and peripheral blood, respectively (55,57). These cells had an overall percentage of V gene mutations comparable to that of the resting CD27 high -IgD low SE B cells described here and, at least in the case of peripheral blood B cells, a comparable phenotype (57). As in the case of our mutated tonsillar IgD low SE B cells, peripheral blood IgM ϩ IgD ϩ memory B cells were found to express CD27 (45).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity of Tonsillar Subepithelial B Lymphocytes, the Splenic Marginal Zone Equivalents

Dono

Zupo²,

Leanza

et al. 2000

The Journal of Immunology

115

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The VH4 genes expressed by both resting and in vivo-activated subepithelial (SE) B cells from human tonsils were studied. Resting SE B cells were subdivided according to the presence (IgDlow) or absence (IgM-only) of surface IgD. CD27 was abundant on activated SE B cells and low on resting IgM-only B cells. Resting IgDlow SE B cells could be subdivided into CD27low and CD27high cell fractions. Resting IgDlow SE B cells displayed VH4 genes with a substantial number of mutations (13/29 of the molecular clones were mutated), whereas 25/26 of the clones from resting IgM-only SE B cells were unmutated. Moreover, mutated VH4 genes were detected mainly within the CD27high cell fraction of the IgDlow SE B cells. Several identical unmutated VH4DJH sequences (11/32) were found in different molecular clones from resting IgM-only SE B cells, suggesting local cellular expansion. Both unmutated (14/25) and mutated (11/25) sequences were found in μ transcripts of activated SE B cells. Extensive mutation was observed in the γ transcripts of activated SE B cells. Therefore, SE B cells are heterogeneous, being comprised of B cells with mutated Ig VH4 genes, that are Ag-experienced B cells, and a subset of B cells with unmutated VH4 genes that are either virgin cells or cells driven by Ags that did not induce or select for V gene mutations.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Heterogeneity of Tonsillar Subepithelial B Lymphocytes, the Splenic Marginal Zone Equivalents

Dono

Zupo²,

Leanza

et al. 2000

The Journal of Immunology

115

View full text Add to dashboard Cite

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“…Paramithiotis and Cooper showed a preferential localization of IgM and IgD expressing CD24 low CD10 − B lymphocytes with somatically mutated antibody genes indicative of antigen experience in the bone marrow 182. Giesecke and colleagues compared numbers and phenotypes of memory B lymphocytes from various human organs, including the bone marrow.…”

Section: Memory B Lymphocytes Of the Bone Marrowmentioning

confidence: 99%

Immunological memories of the bone marrow

Chang

Tokoyoda

Radbruch

2018

Immunological Reviews

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SummaryMemory for antigens once encountered is a hallmark of the immune system of vertebrates, providing us with an immunity adapted to pathogens of our environment. Despite its fundamental relevance, the cells and genes representing immunological memory are still poorly understood. Here we discuss the concept of a circulating, proliferating, and ubiquitous population of effector lymphocytes vs concepts of resting and dormant populations of dedicated memory lymphocytes, distinct from effector lymphocytes and residing in defined tissues, particularly in barrier tissues and in the bone marrow. The lifestyle of memory plasma cells of the bone marrow may serve as a paradigm, showing that persistence of memory lymphocytes is not defined by intrinsic “half‐lives”, but rather conditional on distinct survival signals provided by dedicated niches. These niches are organized by individual mesenchymal stromal cells. They define the capacity of immunological memory and regulate its homeostasis.

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“…14 and 20). In peripheral blood as well as in the bone marrow, memory B cells have been identified in populations of B cells expressing either class-switched Ig isotypes: IgM and IgD, or IgM only (21)(22)(23)(24)(25). More recently, IgD ϩ /CD27 ϩ B cells have been identified as having somatically mutated Ig genes and, therefore, being memory B cells (25).…”

Section: S Ystemic Lupus Erythematosus (Sle)mentioning

confidence: 99%

Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus

Odendahl

Jacobi

Hansen

et al. 2000

The Journal of Immunology

575

490

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In patients with active systemic lupus erythematosus (SLE), a marked B lymphocytopenia was identified that affected CD19+/CD27− naive B cells more than CD19+/CD27+ memory B cells, leading to a relative predominance of CD27-expressing peripheral B cells. CD27high/CD38+/CD19dim/surface Iglow/CD20−/CD138+ plasma cells were found at high frequencies in active but not inactive SLE patients. Upon immunosuppressive therapy, CD27high plasma cells and naive CD27− B cells were markedly decreased in the peripheral blood. Mutational analysis of V gene rearrangements of individual B cells confirmed that CD27+ B cells coexpressing IgD were memory B cells preferentially using VH3 family members with multiple somatic mutations. CD27high plasma cells showed a similar degree of somatic hypermutation, but preferentially employed VH4 family members. These results indicate that there are profound abnormalities in the various B cell compartments in SLE that respond differently to immunosuppressive therapy.

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Memory B lymphocytes migrate to bone marrow in humans

Cited by 125 publications

References 39 publications

Heterogeneity of Tonsillar Subepithelial B Lymphocytes, the Splenic Marginal Zone Equivalents

Heterogeneity of Tonsillar Subepithelial B Lymphocytes, the Splenic Marginal Zone Equivalents

Immunological memories of the bone marrow

Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus

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