Memory Complaints and Memory Impairment in Older Individuals

Jonker, Cees; Launer, Lenore J.; Hooijer, C.; Lindeboom, J.

doi:10.1111/j.1532-5415.1996.tb05636.x

Cited by 209 publications

(177 citation statements)

References 33 publications

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“…To date, studies have investigated the relationship between cognitive complaints and neuropsychological skills in dementia, multiple sclerosis, head injury, chronic fatigue syndrome and Lyme disease, as well as in Gulf War veterans, patients undergoing hemodialysis, and older individuals. Some of these studies have demonstrated an association between cognitive complaints and poorer neuropsychological performance (Gass & Apple, 1997;Jonker et al, 1996;Schofield et al, 1997;Sunderland et al, 1983;Zelinski et al, 1990). Other studies have linked cognitive complaints to affective disturbances such as anxiety or depression (Bassett & Folstein, 1993;Binder, Storzbach, Anger, Campbell, & Rohlman, 1999;Brickman, Yount, Blaney, Rothberg, & De-Nour, 1996;Derouesne et al, 1989;Elkins, Pollina, Scheffer, & Krupp, 1999;Gass & Apple, 1997;Grut et al, 1993;Jorm et al, 1994;Levy-Cushman & Abeles, 1998;O'Connor, Pollitt, Roth, Brook, & Reiss, 1990;Schofield et al, 1997;Wearden & Appleby, 1996) and poor physical health (Bassett & Folstein, 1993;Levy-Cushman & Abeles, 1998).…”

Section: Discussionmentioning

confidence: 99%

Cognitive complaints, depression, medical symptoms, and their association with neuropsychological functioning in HIV infection: A structural equation model analysis.

Carter¹,

Rourke²,

Murji³

et al. 2003

Neuropsychology

129

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The main objective of this study was to use structural equation modeling (SEM) to clarify the relationship between subjective cognitive complaints and neuropsychological functioning in 160 adults with HIV infection. Participants completed questionnaires assessing cognitive complaints, symptoms of depression, and HIV-related medical symptoms. Neuropsychological tests included measures of attention, verbal fluency, psychomotor skills, learning, memory, and executive skills. SEM was used to test models of the relationships among cognitive complaints, mood, and medical symptoms with neuropsychological functioning. The model indicated that although depressed mood (␤ ϭ 0.32, p Ͻ .01) and medical symptoms (␤ ϭ 0.31, p Ͻ .01) influenced cognitive complaints, cognitive complaints were independently associated with poorer neuropsychological performance (␤ ϭ 0.39, p Ͻ .01). Mood and medical symptoms were significantly correlated but were not significantly associated with neuropsychological skills.

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Section: Discussionmentioning

confidence: 99%

Cognitive complaints, depression, medical symptoms, and their association with neuropsychological functioning in HIV infection: A structural equation model analysis.

Carter¹,

Rourke²,

Murji³

et al. 2003

Neuropsychology

129

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“…[42][43][44][45][46] The onset of subjective memory complaints may be a risk factor for development of subsequent cognitive decline. [47][48][49][50] Other research teams have, in contrast, noted that subjective complaints alone do not predict decline in the absence of objective memory loss. 16 Relatives' report of memory deterioration also appears to accurately detect mild cognitive impairment even in the absence of measurable neuropsychological deficits.…”

Section: Clinical Risk Factors For Development Of Dementia and Admentioning

confidence: 99%

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Fellows

Bergman²,

Wolfson³

et al. 2008

Can. j. neurol. sci.

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314As treatments to alleviate symptoms and to slow the progression of Alzheimer's disease (AD) emerge, an increasingly urgent dilemma for physicians is also developing: which of the many elderly individuals with memory complaints will develop Alzheimer's disease, and would therefore be candidates for preventive therapies? An important goal of current research must be to establish useful pre-clinical diagnostic and predictive guidelines, and this can only emerge from longitudinal follow-up of elderly individuals with mild memory loss. In this paper, we report the clinical characteristics of such a group, with the aim of ABSTRACT: Background: To determine whether clinical data obtained by history and physical examination can predict eventual progression to dementia in a cohort of elderly people with mild cognitive impairment. Methods: A prospective, longitudinal study of a cohort of elderly subjects with amnestic Mild Cognitive Impairment (MCI). Ninety subjects meeting the criteria for amnestic MCI were recruited and followed annually for an average of 3.3 years. Main outcome measure was the development of dementia determined by clinical assessment with confirmatory neuropsychological evaluation. Results: Fifty patients (56%) developed dementia on follow-up. They were older, had lower Mini-mental status exam (MMSE) scores and a shorter duration of symptoms at the time of first assessment. Multivariate logistic regression analysis identified age at symptom onset as the only clinical parameter which distinguished the group that deteriorated to dementia from the group that did not. The odds ratio for age was 1.1 (confidence interval 1.04 -1.18). Conclusions: Patients presenting with amnestic MCI insufficient for the diagnosis of dementia are at high risk of developing dementia on follow-up. In our cohort, 56% were diagnosed with dementia over an average period of 5.9 years from symptom onset. The only clinical predictor for the eventual development of dementia was older age at symptom onset. Clinical features alone were insufficient to predict development of dementia.RÉSUMÉ: Les données cliniques peuvent-elles prédire la progression vers la démence dans l'atteinte cognitive légère avec syndrome amnésique? Contexte : Le but de cette étude était de déterminer si les données cliniques provenant de l'histoire médicale et de l'examen physique peuvent prédire la progression éventuelle vers la démence dans une cohorte de gens âgés ayant une atteinte cognitive légère. Méthodes : Il s'agit d'une étude longitudinale prospective d'une cohorte de sujets âgés ayant une atteinte cognitive légère (ACL). Quatre-vingt-dix sujets rencontrant les critères diagnostiques de l'ACL amnésique ont été recrutés et suivis annuellement pendant 3,3 ans en moyenne. Le critère d'évaluation principal était l'apparition d'une démence selon l'évaluation clinique confirmée par une évaluation neuropsychologique. Résultats : Cinquante patients (56%) ont développé une démence au cours du suivi. Ils étaient plus âgés, avaient des scores MMSE plus bas et u...

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“…Subjective memory complaints provide useful health information regarding cognitive aging phenomena and also may predict future cognitive decline (Blazer, Hays, Fillenbaum, & Gold, 1997;Christensen, 1991;Rowe & Kahn, 1987;Jonker, Launer, Hooijer, & Lindeboom, 1996;Verhaeghen, Geraerts, & Marcoen, 2000). Complaints are often evaluated with metamemory questionnaires; however, many studies ask only one or two questions about memory problems, such as "Do you have problems with your memory?"…”

Section: Memory Complaintsmentioning

confidence: 99%

Memory Self-Efficacy and Memory Performance in Older Males

McDougall¹,

Kang²

2003

International Journal of Men's Health

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The study reported here was a secondary analysis of data on 157 males from a larger study of predictors of memory performance in community-dwelling elders. The males' average age was 76 years, with 13 years of education and a Mini-Mental State Exam score of 26. Measures included depression, memory performance, metamemory, and memory self-efficacy. An unusual finding was the multimodal distribution of memory self-efficacy strength scores. Using a median split, the sample was divided into low and high memory self-efficacy groups. The high efficacy group were significantly younger, had larger scores on capacity (+ = high capacity) and change (+ = greater stability). These findings provide new evidence that the memory self-efficacy of aging males influences their perceptions of cognitive performance related to memory.Keywords memory performance; gender difference; aging males; self-efficacy Data from the Health and Retirement study published in Older Americans 2000: Key Indicators of Well Being suggest that in every age cohort older than 65 years, a higher percentage of males than females have moderate or severe memory impairment, defined as four or fewer words recalled out of 20 (Federal Interagency Forum of Aging-Related Statistics, 2000). In both crosssectional and longitudinal studies of memory performance, males performed worse than females and had larger performance decrements (Barrett-Connor & Kritz-Silverstein, 1999;Zelinski, Gilewski, & Schaie, 1993). In one study healthy older males had lower scores on selfreported memory function than females (McDougall, 1998a). In another study of nursing home residents, McDougall (1998b) found scores on the capacity and change metamemory scales were significantly lower in the group with mixed depression and cognitive impairment when compared to a group with cognitive impairment and no depression. This phenomenon of compromised thinking, anxiety, and decreased confidence in memory has been described as mental frailty by McDougall and Balyer (1998) and sense of control by Lachman, Steinberg, and Trotter (1987) and Lachman and Leff (1989). Palmer, Wolkenstein, LaRue, Swan, and Smalley (1994) found that in 6% of a sample of community males (N = 1149), memory performance scores were low enough to be classified as risk for dementia. Larrabee and Crook (1993), who examined 417 male-female pairs, found that males had greater age-associated atrophy of the left hemisphere than women; however, this difference was not manifested in everyday verbal memory. Magnetic resonance imaging studies have also found greater atrophy and shrinkage in the brain structures of men than in the brains of women (Coffey et al., 1998;Larkin, 1998;Palmer et al., 1994 Risk Factors Thought to Contribute to a Decrease in Memory Performance Memory ComplaintsMemory complaints are the subjective aspect of cognitive function and may be related to memory performance in older adults, but findings about this relationship are inconclusive (Comijs, Deeg, Dik, Twisk, & Jonker, 2002;Commissaris, Ponds, & Jol...

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Memory Complaints and Memory Impairment in Older Individuals

Abstract: Simple questions about memory function are related to memory performance in nondepressed, nondemented community-dwelling older people. Subjective memory complaints may be a promising indicator of memory impairment that signals the need for follow-up.

Cited by 209 publications

References 33 publications

Cognitive complaints, depression, medical symptoms, and their association with neuropsychological functioning in HIV infection: A structural equation model analysis.

Cognitive complaints, depression, medical symptoms, and their association with neuropsychological functioning in HIV infection: A structural equation model analysis.

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Memory Self-Efficacy and Memory Performance in Older Males

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