Memory impairment in Alzheimer’s disease

Волобуев, А. Н.; Romanchuk, P.; Romanchuk, N.; Давыдкин, И. Л.; Bulgakova,

doi:10.29296/25877305-2019-06-02

Cited by 21 publications

(3 citation statements)

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“…Рисунок 13. Стабильность иммунитета зависит от здоровой микробиоты кишечника [1] Когнитивное снижение является отличительной чертой старения нервной системы, характеризуется увеличением потери памяти и ухудшением умственных способностей, что в свою очередь создает благоприятный фон для развития нейродегенеративных заболеваний [4,12,13].…”

Section: рисунок 5 последствия дисрегуляции иммунного ответаunclassified

“…В системно-интегративной деятельности головного мозга человека насчитывается огромное количество -примерно 10 млрд. связанных между собой и постоянно взаимодействующих клеток [4]. В исследованиях Н. П.Романчук [55,56] установлено, что системно-локальное и индивидуальное сочетанное (медикаментозное и немедикаментозное) вмешательство в циркадианную ось «микробиота-кишечник-мозг» с помощью ежедневного употребления функциональных продуктов питания, положительно влияет на когнитивное и психическое здоровье человека.…”

Section: рисунок 5 последствия дисрегуляции иммунного ответаunclassified

“…Будущая реализация парадигм системной биологии и системной нейрофизиологии, основанных на комплексном анализе больших и глубоких гетерогенных источников данных, будет иметь решающее значение для достижения более глубокого понимания патофизиологии болезни Альцгеймера, с использованием современных технологий интерфейс «мозг-компьютер» и «искусственный интеллект», для того чтобы увеличить информацию которую можно извлечь от доклинических и клинических показателей. Интеграция различных источников информации позволит исследователям получить новую целостную картину патофизиологического процесса заболевания, которая будет охватывать от молекулярных изменений до когнитивных проявлений [1][2][3][4][5][6][7][8][9].…”

Section: рисунок 5 последствия дисрегуляции иммунного ответаunclassified

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Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Romanchuk

2020

BSP

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The main modern tools and techniques of epigenetic, dietary and biomicrobiotic protection of healthy ageing have been studied. Artificial intelligence, brain-microbiota neural networks allow to control interaction of genetic and epigenetic programs of ageing and healthy longevity. The new managed healthy biomicrobiota and personalized functional and balanced nutrition of ‘brain and microbiota’ is a long-term medical program of the patient, which allows the combined application of nutritional epigenetics and pharmacepigenetics, and the main thing to carry out prevention of polypragmasia. Multimodal tools, biochyping, neural and brain chips, next-generation (new) sequencing technologies create biomarkers to manage the structure of healthy biomicrobiota and functional nutrition, depending on the targets achieved. A functional food product using biomarkers and artificial intelligence technologies is a target breeding ground for both the body in general and biomicrobiota in particular. Chronomedical technologies are mathematical models and artificial intelligence that predict human biological age using DNA methylation data, histone modifications, nucleosome remodeling, and microRNA, and are the most accurate biomarkers of the aging process. Epigenetic mechanisms (DNA methylation, histone modifications, ncRNAs) are interconnected and form an ‘epigenetic network’. Lifestyle factors and environmental exposures leave epigenetic marks on our DNA that impact gene expression; some have protective effects while others are harmful. Genetic and epigenetic factors that ensure longevity and super-longevity require a reasonable new human interaction with nature and society, and responsibility for future healthy generations.

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Section: рисунок 5 последствия дисрегуляции иммунного ответаunclassified

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Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Romanchuk

2020

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Functional Aspects of Memory and Forgetting

Volobuev,

Romanchuk,

Romanchuk

et al. 2024

Vrach

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On the basis of the synaptic connections dynamics between the neurons the processes of occurrence of memory, forgetting and appearances of the new information in a human brain are considered. It is marked, that the huge quantity of the synaptic connections inevitably results to them instability. Forgetting information in norm it is defined by the break of synaptic connections, and memory information it is connected to restoration of these connections. In norm there is a speed balance of these processes. However, if the torn synapse is reconnected to the spine of another neuron, the new information may appear in a brain. As consequence the forgetting the previous information is possible. It is essence of creative process. A savant syndrome and autism are connected to excessive durability of the synaptic connections that results in absence of creative abilities. The impossibility of described dynamics of a brain work technical modelling, i.e. creation of a full-fledged artificial intellect is marked. Some genetic-molecular aspects of the synaptic connections restoration are considered.

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Science of Cognitive Brain and Quantum Biophysics Homo sapiens 21st Century: hybrid Neuroimaging and Nuclear medicine, 5P Medicine and 5G Technology, Neurobiology and Neurophysiology of Quantum Brains, Psychoanalysis, Art-Medicine, Bioelementology and Nutriciology

Volobuev,

Romanchuk,

Romanchuk

et al. 2024

Bulletin of Science and Practice

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New discoveries in the field of genetics and epigenetics, the scientific union of neurobiology and neurophysiology of the quantum brain Homo sapiens of the 21st century, the achievements of biophysics, hybrid neuroimaging and nuclear medicine, the introduction of nutritionology and bioelementology technologies, the 5P of Medicine and 5G Technology, the replication of compliance of art medicine and modern psychoanalysis made it possible to manage 21st century Human cognitive brain. Scientific progress and 33 years of experimental experience of biophysics in the field of neurogeriatrics and neurocardiology, neuroendocrinology and psychoneuroimmunology made it possible to argue that “nerve cells are restored”, the quantum human brain is Controlled, high-quality and healthy longevity Homo sapiens of the 21st century is achievable. Humankind needs to know (discover, prove) in the near future the existence of more than 450 trillion neurosynaptic and neurocosmic interactions between the cognitive mind and the universe.

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Memory impairment in Alzheimer’s disease

Cited by 21 publications

References 0 publications

Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Functional Aspects of Memory and Forgetting

Science of Cognitive Brain and Quantum Biophysics Homo sapiens 21st Century: hybrid Neuroimaging and Nuclear medicine, 5P Medicine and 5G Technology, Neurobiology and Neurophysiology of Quantum Brains, Psychoanalysis, Art-Medicine, Bioelementology and Nutriciology

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