“…As a bionic device, artificial nociceptors can simulate the process of pain generation and have a wide application potential in areas such as electronic skins and artificial muscles, − bringing the gospel to individuals who have lost the ability to detect external stimuli of injury in real time. , Recently, a memristor-based artificial nociceptor was proposed to mimic the basic functions of a humanlike nociceptor and it provided a new approach for the simulation of artificial nociceptors due to their simple structure, stable resistive switching behavior, and low power consumption. ,− Current studies had mimicked pain perception, − i.e., threshold, inadaptation, relaxation, and sensitization by using typical metal-oxide (e.g., TiO 2 or HfO 2 ) memristors. ,,− However, research on the simulation of nociceptive blockade under continuous intense stimulation had been rarely reported, which was attributed to the special conductive mechanism issues of the functional layer. Among several oxide compounds, LiSiO x with a high ionic conductivity, thermal stability, and better biocompatibility is thus widely used in the research of neuromorphic devices. − LiSiO x was considered a highly feasible material for nociceptors with four basic functions due to its excellent resistance behavior.…”