MEMS-based diagnostic microsystems

Polla, Dennis L.; Krulevitch, Peter A; Wang, A.; Smith, Gabriel L.; Díaz, Julián P.; Mantell, Susan C.; Zhou, Jia; Zürn, S.; Nam, Yoonho; Cao, Li; Hamilton, Julie; Fuller, Christopher R.; Gascoyne, Peter R. C.

doi:10.1109/mmb.2000.893737

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…The biologically applications for MEMS is knows as BioMEMS, that describes devices and structures for analytical applications, such as biomolecular recognition and affinity sensors [18,19], devices for chemical and enzymatic diagnostic analyses [20][21][22][23], porous filters fabricated in micro-channels used for bio-cell separation and ELISA [24], impedance measurements for high-throughput drug screening [25], different types of valves for microfluidic use [26][27][28], and a magnetic mixer [29], MEMS structures for microdialysis [30], arrayed microholes for gene therapy applications [31], microfabricated dispensing devices with a precision pipetting head [32] and a drop dispenser [33], and microfabricated templates for scaffolds used in tissue engineering [34].…”

Section: Drug Delivery Using Memsmentioning

confidence: 99%

An Integrated Platform for Bio-Analysis and Drug Delivery

Amer¹,

Badawy

2005

CPB

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The advances in the microelectronics fabrication allow the strong appearance of micro-electro-mechanical systems known as MEMS. MEMS enable the fabrication of smaller devices that are manufactured using standard micro-fabrication techniques similar to the ones that are used to create computer silicon chips. Several MEMS devices including micro-reservoirs, micro-pumps, cantilevers, rotors, channels, valves, sensors, and other structures have been designed, fabricated and tested from using materials that have been demonstrated to be biocompatible. This paper reviews the status of Micro-electronic and MEMS systems that can be used for adaptive drug administration. It presents different components and describes a possible implementation. Finally it presents a prototype that is termed ipill which stands intelligent pill.

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Section: Drug Delivery Using Memsmentioning

confidence: 99%

An Integrated Platform for Bio-Analysis and Drug Delivery

Amer¹,

Badawy

2005

CPB

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“…In recent years the fusion of biotechnology and microelectromechanical systems (MEMS), known as BioMEMS, has enabled biotechnologists to quickly examine large numbers of biological analytes for a range of purposes, from disease diagnosis to detection of bioterrorism agents. A large variety of related products, such as biochip and lab-ona-chip devices [1][2][3], biosensors [4,5], electrotactile displays [6], scaffolds for cell culture [7,8], and biomaterials, are either in development or being commercialized. Numerous advances continue to be made, enabling the development of new platforms for new applications.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of PLGA microvessel scaffolds with circular microchannels using soft lithography

Wang

Hsueh

Hsu

et al. 2007

J. Micromech. Microeng.

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A simple micromolding method for fabricating PLGA (poly(lactic-co-glycolic acid)) microstructures made up of microchannels with a circular cross-section is presented. The thermal reflow technique is adopted to fabricate the semi-cylindrical photoresist master. The PLGA solution is prepared by dissolving PLGA polymer in acetone and then casting the solution onto the semi-cylindrical photoresist master to produce PLGA microstructures. Two PLGA membranes are bonded together to form microstructures consisting of circular microchannels. A microvessel scaffold suitable for tissue engineering was fabricated using the proposed method, and bovine endothelial cells were cultured into the scaffold by semi-dynamic seeding. The cell stain Calcein-AM was used to overcome the problem of the PLGA scaffolds becoming opaque, which in the past had made it difficult to effectively monitor the progress of cell seeding.

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“…Many useful biomedical devices have been developed, e.g. biochip and lab-on-a-chip (Madou et al 2001;Martin et al 2000;Jiang et al 2000), biosensor (Polla et al 2000;Alvarez et al 2003), electrotactile display (Tang and Beebe 2003). It seems feasible to apply the BioMEMS technology to the manufacturing of the capillary network.…”

Section: Introductionmentioning

confidence: 99%

Bio-MEMS fabricated artificial capillaries for tissue engineering

et al. 2005

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In this report, we focus on the microfabrication and cell seeding issues of artificial blood capillaries for tissue engineering. Two different fabrication methods (stainless steel electroforming and silicon electroforming) and a number of materials (PC, Polycarbonate and biocompatible material PLGA, poly lactide-co-glycolides) are implemented to build the vascular network. The vascular network is then used as the scaffold to cultivate the bovine endothelial cell (BEC). During the period of cell cultivation, oxygen and nutrient need to be continuously delivered by a circular pressurizing system. In cell culture, encouraging results are obtained through the dynamical seeding of the BEC on the scaffolds. A systematic cell culture process has been developed after repeated experiments. Successful seeding efficiencies are obtained by using the developed systematic cell culture process

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MEMS-based diagnostic microsystems

Cited by 6 publications

References 3 publications

An Integrated Platform for Bio-Analysis and Drug Delivery

An Integrated Platform for Bio-Analysis and Drug Delivery

Fabrication of PLGA microvessel scaffolds with circular microchannels using soft lithography

Bio-MEMS fabricated artificial capillaries for tissue engineering

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