MEMS devices for drug delivery

Lee, Hyunjoo Jenny; Choi, Nakwon; Yoon, Eui-Sung; Cho, Il‐Joo

doi:10.1016/j.addr.2017.11.003

Cited by 75 publications

(24 citation statements)

References 132 publications

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“…After the in vivo electroporation delivery, the silicon nanoneedle array picked off from the tissue still kept intact structure without breakage (Figure f). With a conical structure and tip diameter below 100 nm, the nanoneedle array would cause minimal damage and avoid possible complication of the mice . These results proved the feasibility of using the biomechanical energy‐driven TENG for drug delivery in vivo.…”

mentioning

confidence: 72%

Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator

et al. 2019

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Nondestructive, high‐efficiency, and on‐demand intracellular drug/biomacromolecule delivery for therapeutic purposes remains a great challenge. Herein, a biomechanical‐energy‐powered triboelectric nanogenerator (TENG)‐driven electroporation system is developed for intracellular drug delivery with high efficiency and minimal cell damage in vitro and in vivo. In the integrated system, a self‐powered TENG as a stable voltage pulse source triggers the increase of plasma membrane potential and membrane permeability. Cooperatively, the silicon nanoneedle‐array electrode minimizes cellular damage during electroporation via enhancing the localized electrical field at the nanoneedle–cell interface and also decreases plasma membrane fluidity for the enhancement of molecular influx. The integrated system achieves efficient delivery of exogenous materials (small molecules, macromolecules, and siRNA) into different types of cells, including hard‐to‐transfect primary cells, with delivery efficiency up to 90% and cell viability over 94%. Through simple finger friction or hand slapping of the wearable TENGs, it successfully realizes a transdermal biomolecule delivery with an over threefold depth enhancement in mice. This integrated and self‐powered system for active electroporation drug delivery shows great prospect for self‐tuning drug delivery and wearable medicine.

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confidence: 72%

Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator

et al. 2019

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“…therapeutic effects of ultrasound neuromodulation on various disease models, it is important to develop an ultrasound neuromodulation system that supports freely-moving experiments. Moreover, such miniaturized neuromodulation tools could also facilitate the investigation of the biological mechanism of ultrasound neuromodulation [3,[17][18][19][20][21][22][23][24]. Here, we propose a light-weight capacitive micromachined ultrasonic transducer (CMUT) ring array suitable for non-invasive brain stimulation for chronic experiments.…”

Section: Introductionmentioning

confidence: 99%

Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals

Kim

Sim

et al. 2019

Brain Stimulation

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“…The concept of microfabricated devices for oral drug delivery has been discussed in several other review papers [13][14][15][16] . In this review, we focus on the latest developments in top-down microfabricated devices for oral drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Microfabricated devices for oral drug delivery

Nielsen

Keller

2018

Lab Chip

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Oral administration of drugs is most convenient for patients and therefore the ultimate goal when developing new medication. The physical barriers in the body, low pH of the stomach and degradation by enzymes in the gastrointestinal tract are a few of the obstacles to succeeding with oral drug delivery. Microfabricated devices show promise to overcome some of these hindrances and thereby improve the bioavailability of drugs after oral administration. There is an increasing focus on microfabricated oral drug delivery systems, and so far there have been three main groups of designs: patch-like structures, microcontainers and microwells. Here, we review the newest development in top-down microfabricated devices for oral drug delivery with coverage of the aspects of design, choice of material and fabrication techniques. Furthermore, the drug loading techniques and methods for testing are discussed. In addition, we discuss the future perspectives for microfabricated devices.

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MEMS devices for drug delivery

Cited by 75 publications

References 132 publications

Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator

Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator

Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals

Microfabricated devices for oral drug delivery

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