Microfabricated devices for oral drug delivery

Nielsen, Line Hagner; Keller, Stephan Sylvest

doi:10.1039/c8lc00408k

Cited by 62 publications

(54 citation statements)

References 65 publications

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“…These devices have been tested in a Caco2 monolayer but are still under improvements and considerations for the intestinal conditions. Further details about similar devices can be found in Chirra and Desai (2012), Fox et al (2014Fox et al ( , 2015, and Nielsen et al (2018).…”

Section: Intestinal Patchesmentioning

confidence: 99%

Oral Drug Delivery Technologies—A Decade of Developments

Kaur

Arora

Kumar

2019

J Pharmacol Exp Ther

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Advanced drug delivery technologies, in general, enable drug reformulation and administration routes, together contributing to life-cycle management and allowing the innovator to maintain the product monopoly. Over the years, there has been a steady shift from mere life-cycle management to drug repurposingapplying delivery technologies to tackle solubility and permeability issues in early stages or safety and efficacy issues in the late stages of drug discovery processes. While the drug and the disease in question primarily drive the choice of route of administration, the oral route, for its compliance and safety attributes, is the most preferred route, particularly when it comes to chronic conditions, including pain, which is not considered a disease but a symptom of a primary cause. Therefore, the attempt of this review is to take a stock of the advances in oral delivery technologies that are applicable for injectable to oral transformation, improve risk-benefit profiles of existing orals, and apply them in the early discovery program to minimize the drug attrition rates.

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Section: Intestinal Patchesmentioning

confidence: 99%

Oral Drug Delivery Technologies—A Decade of Developments

Kaur

Arora

Kumar

2019

J Pharmacol Exp Ther

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“…Oral drug delivery remains the preferred administration route due to ease of use, flexibility and patient compliance [1]. Despite many advances in oral delivery systems [2][3][4], the design of 'the ideal delivery device' is still widely discussed and depends on the application.…”

Section: Introductionmentioning

confidence: 99%

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Christfort

Guillot²,

Melero³

et al. 2020

Pharmaceutics

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An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs. The surface texture and shape of microcontainers have proven to influence the mucoadhesion ex vivo. In the present work, these findings were further investigated using an in situ closed-loop perfusion technique in the rat colon, which allowed for simultaneous evaluation of mucoadhesion of the microcontainers as well as drug absorption. Cylindrical, triangular and cubic microcontainers, with the same exterior surface area, were evaluated based on in vitro release, in situ mucoadhesion and in situ absorption of amoxicillin. Additionally, the mucoadhesion of empty cylindrical microcontainers with and without pillars on the top surface was investigated. From the microscopy analysis of the colon sections after the in situ study, it was evident that a significantly higher percentage of cubic microcontainers than cylindrical microcontainers adhered to the intestinal mucus. Furthermore, the absorption rate constants and blood samples indicated that amoxicillin in cubic microcontainers was absorbed more readily than when cylindrical or triangular microcontainers were dosed. This could be due to a higher degree of mucoadhesion for these particular microcontainers.

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“…Hence, high dose and dosing frequency of eye drops is prescribed to compensate for the low bioavailability, but it causes the side effects and reduces patient compliance [7,8]. To address these drawbacks, therapeutic contact lenses have been proposed for ocular drug delivery, due to their unique properties such as extended wear, high corneal bioavailability (more than 50%) and long drug residence time (over 30 min) in comparison to the eye drop therapy [9][10][11][12][13][14]. The current researches mainly focused on passive drug delivery through sustained diffusion, which still has long release duration and reduced patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Magnetic micropump embedded in contact lens for on-demand drug delivery

Wang

Park

2020

Micro and Nano Syst Lett

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In this paper, we report a thin magnetic micropump embedded in contact lens, which is capable of on-demand one-directional drug delivery. The proposed micropump can be actuated by the external magnetic field whenever needed without the need of battery. A micro check valve was integrated with the micropump for one-directional drug delivery from the micropump to the post-lens tear film. With actuation of the external magnetic field, the micro check valve is opened, and on-demand drug release can be realized. On the contrary, without an external magnetic field, the micro check valve is closed, and the undesired drug diffusion can be prevented. Through the control of the strength and the frequency of the magnetic field pulse, on-demand drug release and controlled dose can be realized. Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Microfabricated devices for oral drug delivery

Cited by 62 publications

References 65 publications

Oral Drug Delivery Technologies—A Decade of Developments

Oral Drug Delivery Technologies—A Decade of Developments

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Magnetic micropump embedded in contact lens for on-demand drug delivery

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